Evaluating Use Cases for Human Challenge Trials in Accelerating SARS-CoV-2 Vaccine DevelopmentSARS-CoV-2 백신 개발을 가속화하기 위한 인간 챌린지 시험의 사용 사례 평가Article Published on 2021-02-162022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, 임상, [키워드] accelerate challenge controlled human infection COVID-19 development Efficacy effort Evaluating HCT Human human challenge trial human immune response human infection identify limitation option pandemic Pathogenesis preparation preserved SARS-CoV-2 SARS-CoV-2 vaccine Stage Trial use cases utility Vaccine vaccine candidate vaccine candidates vaccine evaluation virus [DOI] 10.1093/cid/ciaa935 PMC 바로가기 [Article Type] Article
The rise of point-of-care genetics: how the SARS-CoV-2 pandemic will accelerate adoption of genetic testing in the acute setting현장 진료 유전학의 부상: SARS-CoV-2 대유행이 급성 환경에서 유전자 검사의 채택을 가속화하는 방법Viewpoint Published on 2021-02-152022-09-12 Journal: European Journal of Human Genetics [Category] Coronavirus, MERS, SARS, 신약개발, 유전자 메커니즘, 진단, [키워드] accelerate Diagnostic markers Genetic testing pandemic point-of-care the SARS-CoV-2 [DOI] 10.1038/s41431-021-00816-x PMC 바로가기 [Article Type] Viewpoint
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2Microbiology Published on 2021-02-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 384-well format accelerate acute respiratory syndrome addition antibodies antibody Combination condition coronavirus disease Coronavirus-2 Coronaviruses demonstrated human-to-human transmission immuno-plaque assay (iPA) immunofluorescence methodology Neutralization assay outcome pandemic Plaque assay quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research significantly Spread Viral detection viral quantification [DOI] 10.3389/fmicb.2021.625136 PMC 바로가기 [Article Type] Microbiology
Immunological characteristics govern the transition of COVID-19 to endemicity면역학적 특성은 COVID-19의 풍토병으로의 전환을 지배합니다Report Published on 2021-02-122022-09-12 Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 진단, [키워드] accelerate acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adult disease age age distribution Analysis assumption cause Characteristics childhood children common cold component coronavirus COVID-19 disease distribution Elimination Endemic endemic human coronavirus endemic human coronaviruses endemicity Epidemic epidemiological data evaluate groups HCoVs human coronavirus immune response Immunity immunological Mild outcome pandemic predict Primary infection PROTECT question reached Reinfection respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe disease severity Severity of infection shift spreads sterilizing immunity trajectory transition turn vaccination Vaccine virulent virus widespread [DOI] 10.1126/science.abe6522 PMC 바로가기 [Article Type] Report
Promoting versatile vaccine development for emerging pandemicsPerspective Published on 2021-02-112022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] accelerate approach COVID-19 pandemic demonstrated Diseases flexible medical countermeasure Medical research pandemic Pandemics pathogen pathogen-specific Pathogens platform Preclinical research promote Promoting Research SARS-CoV-2 vaccine translate Vaccine Vaccine development vaccine platform Vaccines [DOI] 10.1038/s41541-021-00290-y PMC 바로가기 [Article Type] Perspective
An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case studyArticle Published on 2021-02-052022-10-04 Journal: Scientific Reports [Category] MERS, 변종, [키워드] 3D structure accelerate antigenicity approach approaches B-cell epitopes candidate caused Clinical studies Computational platforms and environments Coverage CTL CTL epitope cytotoxic deaths deep learning disease effective Efficiency epitope Epitopes evaluated expression good quality helper HTL HTL epitopes identify immunoinformatics in silico In silico method Infectious disease linear B-cell epitopes machine learning Multi-epitope vaccine Mutation Peptide vaccines physicochemical property Plasmid predict predicted Protein design Protein function predictions RNA SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus secondary structure sequence Spread spread of COVID-19 subunit the SARS-CoV-2 the vaccine therapy Toxicity Vaccine viral infection virus [DOI] 10.1038/s41598-021-81749-9 PMC 바로가기 [Article Type] Article
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitorsArticle Published on 2021-02-022022-10-04 Journal: Nature Communications [Category] 치료제, [키워드] accelerate antiviral drug target antivirals assays biochemical caused Cell culture cleavage complex complexes Compound coronavirus 2 crystal structure drug design effort enzyme expand host responses identify in vitro inhibit inhibitor inhibitors Interaction maturation molecular Molecular biology mutant pandemic Papain-like protease PLPro polyproteins protease Proteases respiratory SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 replication Structure the SARS-CoV-2 virus replication wild-type X-ray crystallography [DOI] 10.1038/s41467-021-21060-3 PMC 바로가기 [Article Type] Article
De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learningResearch Article Published on 2021-02-022022-10-27 Journal: BMC Chemistry [Category] COVID-19, [키워드] absence accelerate active against acute respiratory syndrome addition Antiviral antivirals approved artificial intelligence baseline binding Bioactivity can be used caused Classifier Compound coronavirus coronavirus disease COVID-19 COVID-19 pandemic de novo de Novo drug design deep learning displaying drug candidates Drug discovery Generative model global pandemic Human identify in viral inhibitor inhibitors inhibitors of SARS-CoV-2 Interaction M pro methodology molecular docking nine offer overlap physicochemical property platform predicted protease Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro screened structures transfer transfer learning Treatment Ulmfit Vaccine [DOI] 10.1186/s13065-021-00737-2 PMC 바로가기 [Article Type] Research Article
SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammationShort Review Published on 2021-02-012022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] accelerate acute respiratory syndrome Affect Angiogenesis Anosmia Blood blood clot blood oxygen level Brain brain tissue breathlessness capillary dysfunction cause changes chest pain circulation Confusion consequence contribute Corona virus COVID‐19 COVID‐19 patient COVID‐19 symptom COVID‐19 Critical cytokine level delirium deteriorate diabetes diagnostic methods diffusion disease Effect elevated Endothelial cell Endotheliitis fatigue function Health heart hypertension Hypoxemia hypoxia identify Infection Inflammation instance limit long‐term symptoms Loss of Smell lung Lungs management memory Microcirculation Microvascular damage multiple organ muscle organ organs oxygen Oxygenation pericyte problem PROTECT rashes rehabilitation SARS‐CoV‐2 infection scar stimulate Symptom therapeutic tissue tissue damage tissue repair turn upstream Vascular vicious cycle virus weakness [DOI] 10.14814/phy2.14726 PMC 바로가기 [Article Type] Short Review
Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates접촉 추적과 COVID-19 사례 치사율 사이의 연관성에 대한 국가 간 증거Article Published on 2021-01-252022-09-10 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] accelerate addition adopted association Care Case fatality rate case fatality rates Combination conducted Contact tracing coronavirus coronavirus disease country COVID-19 COVID-19 case diagnostic diminishe Early detection effort Epidemiology evaluate Evidence Fatality rate Health policy Healthcare system individual infected individual infected individuals infectiousness intensity Isolation measure Medical care occur outbreak presymptomatic public health receive reduced reducing regression analysis regression models resource robust secondary case secondary cases significantly lower Transmission turn Variability [DOI] 10.1038/s41598-020-78760-x PMC 바로가기 [Article Type] Article