Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoVArticle Published on 2020-01-102022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] antiviral activity Antiviral agents antiviral drug approved Combination combination therapy Comparative country death disease Drug development Efficacy evaluated Evidence Human human infection Ifnb IMPROVE in vitro in vivo infections interferon beta Kingdom LPV LPV/RTV-IFNb lung viral load MERS coronavirus MERS-CoV MERS-CoV infection mice Middle East not reduce parameters Prophylactic Pulmonary function RDV reduce Remdesivir respiratory syndrome coronavirus Ritonavir RTV Saudi Arabia severe lung pathology severe respiratory disease therapeutic therapeutic efficacy treat Treatment viral infection Viral load viral pathogenesis virus replication [DOI] 10.1038/s41467-019-13940-6 PMC 바로가기 [Article Type] Article
A Comparative Analysis of Factors Influencing Two Outbreaks of Middle Eastern Respiratory Syndrome (MERS) in Saudi Arabia and South KoreaReview Published on 2019-12-032022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] addition Analysis Comparative coronavirus country death Endemic epidemiological Factor Fatality rate healthcare healthcare worker hospital IMPROVE information knowledge laboratory-confirmed MERS MERS-CoV middle Middle East Middle East Respiratory Syndrome (MERS), zoonosis occurred outbreak Outbreaks outcome Patient Perspective progression PROTECT reservoirs respiratory responses Saudi Arabia South Korea spread to synchronization Transmission viral infection virus World Health Organization [DOI] 10.3390/v11121119 PMC 바로가기 [Article Type] Review
East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide동아시아 헬리코박터 파일로리 균주는 헵탄 결핍 지방 다당류를 합성합니다Research Article Published on 2019-11-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence analysed Antigen Asia Bacterial biosynthetic biosynthetic gene biosynthetic pathway Cancer Comparative Complete conservation conserved correlation demonstrated distal East enzyme European expressed Future Gal Genes Genome Genomic analysis GlcNAc H . pylori Helicobacter pylori heptan host-pathogen interactions Immune escape initiate involved lack lipopolysaccharide motif Mutagenesis pathogen Pathogenesis pathway promote strain Strains Structural analysis Structure surface molecule synthesis Trio trisaccharide [DOI] 10.1371/journal.pgen.1008497 PMC 바로가기 [Article Type] Research Article
Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon ResolutionGenome Replication and Regulation of Viral Gene Expression Published on 2019-06-262022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Analysis avian coronavirus Cell cellular changes in chick coding region Comparative complex conserved Coronaviruses data set Differential gene expression differentially expressed downstream Efficiency expand facilitated form Frame Gene Expression gene network generate Genome genomic RNA High-resolution host cell response host genes IBV IBV infection Improved include indicated Infection Infectious Bronchitis Virus isolates kidney Like Molecular biology mRNA transcript nucleocapsid occur ORF ORF4b pathogen pathogenic positive-sense quantification Replication Resolution ribosome profiling RNA genome RNA virus RNAseq Sequencing sgmRNA sgmRNA transcripts sgmRNAs Single nucleotide polymorphism single-stranded Spread strain Strains subgenomic mRNA Transcription translation translational Triplet upregulation Vaccination strategy vaccine candidate Variation viral RNA synthesis virus virus infection [DOI] 10.1128/JVI.00714-19 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017Article Published on 2019-05-142022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] age analyzed Clinical data Comorbidity Comparative death dropped epidemiological healthcare healthcare personnel heterogeneity highlight hospital increased mortality Infection Infectious diseases Kingdom laboratory-confirmed limitation MERS MERS case MERS-CoV Middle East MOST multivariate analyses outbreak Outbreaks Protective provide quantified ranged reported Reproduction number respiratory Respiratory pathogens respiratory syndrome coronavirus Risk factors Saudi Arabia Stress Transmission World Health Organization [DOI] 10.1038/s41598-019-43586-9 PMC 바로가기 [Article Type] Article
Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in QatarResearch Article Published on 2019-02-182022-10-29 Journal: Journal of Immunology Research [Category] Coronavirus, [키워드] 229E Active surveillance antibody Asymptomatic baseline circulating close contact collected Comparative Contact coronavirus cross-reactivity determine epidemiological evaluate exhibited false-positive result FIVE General population group healthy blood donor HKU1 human coronavirus IgG IgM individual initial screening MERS-CoV MERS-CoV infection Middle East Mild neutralization NL63 OC43 PCR-confirmed patient positive Prevalence Randomly reactive reactivity reported respiratory syndrome coronavirus Sample screened selected Serological assay serological assays [DOI] 10.1155/2019/1386740 PMC 바로가기 [Article Type] Research Article
Comparative features of infections of two Massachusetts (Mass) infectious bronchitis virus (IBV) variants isolated from Western Canadian layer flocksResearch Article Published on 2018-12-102022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] bronchitis cause characterized Comparative cross protection distribution elicited evaluated Evidence feature genetic difference Genetic variations Genome host response host responses IBV Infection Infectious Bronchitis Virus isolate isolates lung M41 Macrophage Macrophage response macrophages mass Massachusett morbidity Mortality nucleotide nucleotide sequence Open reading frame ORF ORFs Pathogenesis pathogenicity recruit recruitment replicate replicated required respiratory tract Result resulting Sequencing serotype significant difference similarity supplementary material tissue Tissue distribution tonsils tracheal vaccinal Vaccines variant variants viral replication virus whole genome Whole genome sequencing [DOI] 10.1186/s12917-018-1720-9 PMC 바로가기 [Article Type] Research Article
Comparative studies of alignment, alignment-free and SVM based approaches for predicting the hosts of viruses based on viral sequencesArticle Published on 2018-07-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] applied approach Comparative conserved coronavirus correlated dinucleotide Diseases Frequency gene sequences Host influenza A virus influenza A viruses investigated K -mer pandemic predict Rabies virus Sample size sequence spike gene Support Surveillance SVM time-consuming Variability viral sequence virus viruses [DOI] 10.1038/s41598-018-28308-x PMC 바로가기 [Article Type] Article
Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathwaysResearch Article Published on 2017-08-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] aa deletion absence activate affected Analysis Apoptosis arginine cellular Characteristics Comparative conserved E protein eight envelope protein epidemic diarrhea ER stress expression Frame functional protein Genes genomic variation glycine GRP78 homologous host cell identification IL-6 IL-8 independent induce Infection membrane fusion morphology Mutation pathway PEDV potential mechanism pro-inflammatory cytokine proliferate proliferation protease Protein Receptor binding Replication responsible S2′ cleavage screened single mutation strain supplementary material transmembrane domain trypsin Variation Vero cells virion virus virus titer whole genome sequence α-coronavirus [DOI] 10.1186/s13567-017-0449-y PMC 바로가기 [Article Type] Research Article
Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South KoreaOriginal Article Published on 2017-06-072022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] age Analysis Characteristics Chi-square collected Comorbidity Comparative complex conducted Contact country Emerging infectious disease Epidemic epidemic curve Epidemics epidemiological Epidemiology exhibited health system hospital infections Kingdom Logistic regression male MERS case MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus nosocomial occurred outbreak Outbreaks Prevent proportion reported resources respiratory syndrome coronavirus risk risk factor Risk factors Saudi Arabia Saudi MOH South Korea spread to Travel WHO World Health Organization [DOI] 10.1038/emi.2017.40 PMC 바로가기 [Article Type] Original Article