The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19)Review Published on 2021-05-032023-07-02 Journal: Carbohydrate Research [Category] SARS, [키워드] antivirals COVID-19 Drug repurposing immunomodulators SARS-CoV-2 sulfated polysaccharide [DOI] 10.1016/j.carres.2021.108326 PMC 바로가기 [Article Type] Review
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭Review Published on 2021-05-022022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses [DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review
In silico identification of available drugs targeting cell surface BiP to disrupt SARS-CoV-2 binding and replication: Drug repurposing approachResearch article Published on 2021-05-012022-10-05 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 신약개발, [키워드] Acute inflammation analyzed anti-inflammatory drug antiviral agent Apoptosis appear approach azosemide bind binding BiP candidate caspase-dependent apoptosis Cell cell surface contribute COVID-19 COVID-19 / SARS-CoV-2 COVID-19 patients disrupt docking domain drug Drug repurposing drugs targeting expressed extrinsic FDA-approved drug functional Grapiprant hepatitis C virus identify Immune cell infected cells Inflammation inhibit Ligand molecular docking NBD Netupitant neutralize performed polypeptide predicted Prevent protease Protein receptor receptor protein Replication SARS-CoV-2 selected Significance susceptible therapeutic target treat Trigger triggering velpatasvir viral replication [DOI] 10.1016/j.ejps.2021.105771 [Article Type] Research article
Drug repositioning based on similarity constrained probabilistic matrix factorization: COVID-19 as a case studyResearch article Published on 2021-05-012022-10-05 Journal: Applied Soft Computing [Category] 신약개발, 치료제, [키워드] Accuracy approach approaches Benchmarking build caused comparison COVID-19 COVID-19 crisis database dataset drug drug candidate Drug discovery drug repositioning Drug repurposing Drug–disease associations prediction Drug–virus interactions prediction effort genomic Health heterogeneous Human identify information Interaction interactions new virus novel coronavirus disease outperform pandemic reliability similarity Similarity constrained probabilistic matrix factorization structures supported treatment strategy Vaccine virus viruses [DOI] 10.1016/j.asoc.2021.107135 [Article Type] Research article
Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19COVID-19의 신경학적 징후를 설명하기 위한 뇌 질환 네트워크 분석Article Published on 2021-05-012022-09-11 Journal: Molecular neurobiology [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis approach association assumed Brain Brain Disease Care catabolic cause Cell cell cycle clinical condition clinical conditions Comorbidity COVID-19 COVID-19 infection COVID-19 patients Disease-gene interaction disorder drug Drug repurposing Effect FIVE gene network Genetic genetic association greater Health Health care Health care system high-density hub genes hub protein IMPROVE infection mechanism investigated involved manifestation metabolic process molecular basis Mortality network network biology neurologic Neurologic comorbidity. neurological manifestation neurological manifestations Neurological symptoms nuclear patients with COVID-19 Protein report Respiratory complications resulting RNA SARS-CoV-2 Transport with COVID-19 [DOI] 10.1007/s12035-020-02266-w PMC 바로가기 [Article Type] Article
Virtual screening FDA approved drugs against multiple targets of SARS-CoV-2SARS-CoV-2의 다중 표적에 대한 가상 스크리닝 FDA 승인 약물Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 신약개발, [키워드] (avapritinib antiviral drug avapritinib bictegravir binding site candidate Capmatinib causative agent Clinical studies conformation conserved coronavirus disease Coronavirus disease 2019 COVID-19 docked drug Drug administration drug candidate drug candidates Drug discovery Drug repurposing drugs effective effective drug effective drugs effort FDA approved drug food global pandemic Guidance host protein host proteins in silico in vitro in vivo incorporation life cycle molecular Molecular assay morbidity and mortality Novel coronavirus outbreak pexidartinib Protein representing respiratory Respiratory disease SARS-CoV-2 screened small molecule Small molecules Stage target target proteins targeting therapeutic Treatment Vaccine Viral protein Viral proteins virus ziprasidone [DOI] 10.1111/cts.13007 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferaseSARS-CoV-2 표적화: 3C-유사 프로테이나제 및 2'-O-리보스 메틸트랜스퍼라제에 대한 유망한 억제제를 식별하기 위한 체계적인 약물 용도 변경 접근법Article Published on 2021-05-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] 2′-O-ribose methyltransferase 3C-like proteinase 3CLpro active site antiviral drugs approach bictegravir binding candidate computational analysis contagious Coronaviridae family cysteine cysteine protease docking dolutegravir drug Drug repurposing drug target free energy functional host immune system house identify imperative inhibitor interacting residues lead life cycle MD simulation methyltransferase mRNA nucleotide number of infected Orientation pandemic parameter paritaprevir physiological state Protein protein-drug complex protein-drug complexes proteinase Proteins proteolysis raltegravir replicase polyprotein replicase polyproteins responsible resulting ribose SARS-CoV-2 screened selected targeting targets the Coronaviridae therapeutic drug Viral viral life cycle Virtual screening virus [DOI] 10.1080/07391102.2020.1753577 PMC 바로가기 [Article Type] Article