epitope – Page 33 – Communicable Diseases Research

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성

Research Paper

Published on 2022-01-012022-09-01
Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단,

Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries

대규모 합성 파지 라이브러리에서 다양한 중화 SARS-CoV-2 항체의 신속한 발견

Article

Published on 2022-01-012022-09-11
Journal: mAbs [Category] 변종, 진단,

[키워드] Alpha antibody Beta bind binding candidate characterization complementarity-determining region coronavirus disease Coronavirus disease 2019 COVID-19 Delta disease epitope Features Gamma global public health Health crisis high affinity IgG in vitro in vivo limit mAbs monoclonal antibodies monoclonal antibody N-terminal domain Neutralizing Neutralizing activity neutralizing antibody neutralizing SARS-CoV-2 antibody passive immunization Rapid Receptor-binding domain retained S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants spike glycoprotein Spike protein synthetic libraries synthetic libraries. the receptor-binding domain the S1 subunit therapeutic options therapeutic strategy unique while
[DOI] 10.1080/19420862.2021.2002236 PMC 바로가기 [Article Type] Article

Antibody-mediated immunity to SARS-CoV-2 spike

Article

Published on 2022-01-012022-11-15
Journal: Advances in Immunology [Category] 변종, 진단,

Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity

Article

Published on 2022-01-012022-11-15
Journal: Gut Microbes [Category] SARS, 진단,

[키워드] anti-SARS-CoV-2 antibodies antibody Antibody titer Bacteria binding collected commensal gut bacteria correlated COVID-19 vaccine cross-react cross-reactive cross-reactive antibody demonstrated DNA vaccine domain dominant dose E. coli Efficacy epitope fecal Gut gut bacteria gut microbiota healthy Host Hsp60 Hsp70 Immunity immunized Impact inactivated LC-MS metagenomic sequencing mice microbial monoclonal antibodies monoclonal antibody mounted naïve P144 Protein RBD binding reactive S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 vaccination SPF Spike protein Vaccine vaccine immunogenicity variety
[DOI] 10.1080/19490976.2022.2117503 PMC 바로가기

A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates

Research article

Published on 2022-01-012022-10-05
Journal: Vaccine [Category] 비임상,

[키워드] alleles Antigen approach BALB/c binding CD4+ CD4+ T cell CD8+ T cell cellular immunity conserved costly Coverage COVID-19 described Diseases DNA vaccine Electroporation elicit elicited ENCODE epitope Epitope-based vaccine Epitopes Evidence facilitate generate HIV HIV vaccine HLA class II HLA-DR immune response immunization immunized immunodominant immunogen in vivo Increasing induce less MHC mice multiple epitopes Multiple HLA-binding epitopes neutralizing antibody over patients peptides platform Populational vaccine response Result rhesus macaque rhesus macaques shown T cell T cell epitope T cell response transgenic Vaccine Vaccines viral disease viral infections
[DOI] 10.1016/j.vaccine.2021.11.076 [Article Type] Research article

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포

Research Article

Published on 2021-12-292022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법,

[키워드] Activation allele Amino acid amino acid sequence Amino acid sequences Analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population
[DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article

Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

Research Article

Published on 2021-12-222022-10-30
Journal: JCI Insight [Category] COVID-19, SARS,

Identification of HLA-A*24:02-Restricted CTL Candidate Epitopes Derived from the Nonstructural Polyprotein 1a of SARS-CoV-2 and Analysis of Their Conservation Using the Mutation Database of SARS-CoV-2 Variants

SARS-CoV-2의 비구조적 다단백질 1a에서 파생된 HLA-A*24:02-제한된 CTL 후보 에피토프의 식별 및 SARS-CoV-2 변이체의 돌연변이 데이터베이스를 사용한 보존 분석

Research Article

Published on 2021-12-222022-09-10
Journal: Microbiology Spectrum [Category] SARS, 변종, 진단,

[키워드] Administered affected Algorithms Amino acid amino acid sequence Amino acid sequences Analysis candidate CD8 conservation conserved conserved epitope COVID-19 COVID-19 vaccine Critical CTL CTL epitope CTLs cytotoxic T lymphocyte cytotoxic T lymphocytes database East Asian East Asians effective elicit epitope Epitopes Evidence HLA-A HLA-A*24:02 identification Immunity information Japanese less Lymphocytes mutated Mutation Neutralizing antibodies neutralizing antibody nonstructural proteins pandemic polyprotein pp1a predominant Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequence Read Archive spike Spike protein the Spike transgenic mice Transmissibility Vaccine variant variants Viral viral control viral evolution virus
[DOI] 10.1128/spectrum.01659-21 PMC 바로가기 [Article Type] Research Article

Immune Responses in Pregnant Sows Induced by Recombinant Lactobacillus johnsonii Expressing the COE Protein of Porcine Epidemic Diarrhea Virus Provide Protection for Piglets against PEDV Infection

Article

Published on 2021-12-212022-10-28
Journal: Viruses [Category] Coronavirus,

[키워드] Lactobacillus johnsonii (L. johnsonii) activate administration antibody Antigen cause Cell cellular immune responses COE COE antigen dendritic cell develop effective epidemic diarrhea epitope evaluated expressing humoral IgA IgG antibody IgM antibody immune protection immune responses immunomodulatory effect in vitro induced Infection Infectious disease intestinal lactobacillus maturation mucosal Neutralizing Oral Immunization Oral vaccine PEDV pregnant pregnant sow protection Protein recombinant response secretory immunoglobulin A serum IgG SIgA triggered vaccination Vaccine viral spike protein virus
[DOI] 10.3390/v14010007 PMC 바로가기 [Article Type] Article

Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern

2중 파라토프 나노바디는 우려되는 SARS-CoV-2 변종으로 인한 치명적인 공격으로부터 마우스를 보호합니다

Article

Published on 2021-12-202022-09-10
Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] (Beta active against Analysis B.1 B.1.351 B.1.617.2 Beta cellular circulating circulating variant conserved COVID‐19 Delta Disease progression dose drug candidates effective epitope epitope mapping Epitopes generate high affinity human ACE‐2 mouse human ACE2 immunology in vitro in vivo increased survival Infection Inflammatory response intranasally lethal dose Lungs mice Microbiology, Virology & Host Pathogen Interaction Molecular Biology of Disease nanobodies nanobody neutralize Neutralizing neutralizing nanobodies pandemic Prevent PROTECT RBD receptor‐binding domain reduced SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly Taking Therapeutics These data transgenic mice treat treated variants of concern variety Viral Viral load VoC VOCs
[DOI] 10.15252/embr.202153865 PMC 바로가기 [Article Type] Article