Children and adolescents in the CoVid-19 pandemic: Schools and daycare centers are to be opened again without restrictions. The protection of teachers, educators, carers and parents and the general hygiene rules do not conflict with thisArticle Published on 2020-05-282022-11-01 Journal: GMS Hygiene and Infection Control [Category] COVID-19, [키워드] accompanied activities adolescents Adults age Analysis analysis approach assigned Asymptomatic automatically avoidance children China Clustering constancy Contact Course demonstrated Effectiveness event evidence of groups hygiene implementation independent of Infection infection control Infection prevention infection rate infection with SARS-CoV-2 Infectious disease kindergarten less majority measure Measures medical masks parent precautions question required resources SARS-CoV-2 School Spread supported Surveillance Taking tested Transmission transmission of SARS-CoV-2 virus wearing masks [DOI] 10.3205/dgkh000346 PMC 바로가기 [Article Type] Article
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 Research Published on 2020-05-262022-10-05 Journal: Nature [Category] SARS, 변종, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 CA1 caused coronavirus coronavirus disease countermeasure COVID-19 demonstrated dissemination domain epitope Human monoclonal antibody in vitro infection with SARS-CoV-2 inhibited Interaction Interface residues interfere Isolation neutralization activity neutralizing antibody outbreak overlap Patient performed Prevent Prophylactic recognize Rhesus monkey SARS-CoV-2 Spread steric hindrance target the SARS-CoV-2 translation treat Treatment virus [DOI] 10.1038/s41586-020-2381-y [Article Type] Research
Interferon-α2b Treatment for COVID-19COVID-19에 대한 인터페론-α2b 치료Immunology Published on 2020-05-152022-08-13 Journal: Frontiers in Immunology [Category] MERS, 임상, [키워드] adults hospitalized antiviral intervention approved Arbidol ARDS blood biochemistry Blood level blood levels Blood oxygen saturation blood oxygen saturation levels caused cell counts Cohort Combination confirmed COVID-19 case COVID-19 COVID-19 case COVID-19 cases CRP cytokine detectable Effect elevated exploratory study global pandemic hematological measurements Hospital stay IFN-α2 IFN-α2b IFN-α2b plus arbidol IL-6 infection with SARS-CoV-2 Inflammation Inflammatory marker inflammatory markers interferon investigated nebulized oxygen Patient reduced respiratory SARS-CoV-2 testing serum cytokine serum cytokine levels significantly temperature therapy treated Treatment upper respiratory tract viral shedding virus were recorded Wuhan Wuhan, China [DOI] 10.3389/fimmu.2020.01061 PMC 바로가기 [Article Type] Immunology
COVID-19 and ophthalmology: an underappreciated occupational hazardConcise Communication Published on 2020-05-152022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, MERS, SARS, [키워드] Conjunctival secretion conjunctivitis coronavirus COVID-19 described increased risk Infection infection with SARS-CoV-2 Mask patients with COVID-19 required respiratory droplet SARS-CoV-2 slit-lamp Transmission [DOI] 10.1017/ice.2020.238 PMC 바로가기 [Article Type] Concise Communication
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets Research Published on 2020-05-142022-10-05 Journal: Nature [Category] SARS, 치료제, [키워드] acute respiratory syndrome analysis carbon metabolism cause Cell cells cellular cellular pathway coronavirus coronavirus disease COVID-19 drug effort homeostasis host cell Human human cells identify infect Infection infection with SARS-CoV-2 inhibit inhibitor modulated modulation molecular mechanism New coronavirus nucleic acid metabolism pathway Prevent prevented Protein proteome proteomics reveal SARS-CoV-2 similarity target therapy translation Treatment underlie viral replication [DOI] 10.1038/s41586-020-2332-7 [Article Type] Research
Coronavirus Disease and New-Onset Atrial Fibrillation: Two CasesCardiology Published on 2020-05-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Atrial fibrillation Care clinical presentation coronavirus coronavirus disease Course COVID-19 diagnosed diagnosed with COVID-19 Diagnosis discharged home dysregulation electrocardiogram Fever Hospitalization identify illnesses Infection infection with SARS-CoV-2 manifestation mechanism men morbidity and mortality palpitations past medical history Patient physician presenting reported respiratory manifestations SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 symptomatic treated worsening [DOI] 10.7759/cureus.8066 PMC 바로가기 [Article Type] Cardiology
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages Reviews Published on 2020-05-062022-10-05 Journal: Nature reviews. Immunology [Category] SARS, 임상, 치료제, [키워드] caused COVID-19 pandemic death disease severity dysregulated Host Hyperinflammatory infected patients Infection infection with SARS-CoV-2 Inflammation Inflammatory innate immune cell Macrophage macrophage activation macrophage activation syndrome microbial modulate monocyte pathogen pathological pathological role Patient patients with COVID-19 producing promote respond SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe infections therapeutic strategy threat tissue repair virus [DOI] 10.1038/s41577-020-0331-4 [Article Type] Reviews
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19Review Published on 2020-04-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 approach Calu-3 Camostat mesylate Chloroquine clinical clinically compassionate use Coronavirus infection Coronavirus-2 country COVID-19 demonstrated develop enzyme human lung cells in vitro Infection infection with SARS-CoV-2 inhibit Interaction management Novel coronavirus novel coronavirus SARS-CoV-2 outbreak patients with COVID-19 pharmacological Pneumonia Prevent Protease inhibitor Protein proteinase RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-COV-2 infection shown spike spike glycoproteins Spread systemically targeting the S protein The United States therapeutic approach Therapeutics Transmission treated Treatment viability [DOI] 10.3390/jcm9041131 PMC 바로가기 [Article Type] Review
A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic virusesReview Published on 2020-03-142022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus acute respiratory distress acute respiratory syndrome animal hosts Antiviral Asymptomatic cell death clinical manifestation Committee concern concerning coronavirus coronavirus disease COVID-19 Defense Emergency highly pathogenic Host host antiviral response Human human coronavirus human coronaviruses humans immunodeficiency infect infection with SARS-CoV-2 Interaction Middle East Mild moderate outbreak outcome pathogenic virus pathogenicity Pneumonia presymptomatic Proinflammatory cytokine provide Public question respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection Severe case syndrome taxonomy Transmissibility type I interferon virus virus World Health Organization zoonotic origin [DOI] 10.1080/22221751.2020.1736644 PMC 바로가기 [Article Type] Review
Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank SubjectsACE2 및 TMPRSS2 유전자의 변이는 영국 바이오뱅크 피험자에서 COVID-19 심각도의 주요 결정 요인이 아닙니다Article Published on 2020-01-012022-09-11 Journal: Human heredity [Category] SARS, 변종, [키워드] ACE2 affecting Analysis carried conducted contribute Control controls COVID-19 COVID-19 severity determinant determine develop DNA sequence Effect effect sizes explain Frequency genetic variants infection with SARS-CoV-2 Major positive rare variant Rare variants Research SARS-CoV-2 sequence sequenced severe disease severe symptom severe symptoms severity statistically significant difference subject subjects tested TMPRSS2 TMPRSS2 protein TMPRSS2. UK biobank variant variants Variation was obtained [DOI] 10.1159/000515200 PMC 바로가기 [Article Type] Article