Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccinationArticle Published on 2022-11-012022-11-15 Journal: Journal of Immunological Methods [Category] SARS, 진단, 치료기술, 치료제, [키워드] Antibody Response Antigen antigenic target assays correlated COVID-19 IgG immune response increasingly Infection infection with SARS-CoV-2 measure measurement multiplex Multiplex assay nucleocapsid antigen performance platform Quantitative ranged RBD Receptor binding domain S1 and S2 SARS-CoV-2 SARS-COV-2 infection sensitivity serologic assay Serologic response serology specificity subunit vaccination Variation [DOI] 10.1016/j.jim.2022.113345 PMC 바로가기
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant variants virulence virus virus infection virus load WA1 while [DOI] 10.1128/mbio.02421-22 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Effects of Wearing FFP2 Masks on SARS-CoV-2 Infection Rates in ClassroomsArticle Published on 2022-10-192022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] appear children classroom COVID-19 cumulative Delta Effect FFP2 incidence infected with SARS-CoV-2 Infection infection with SARS-CoV-2 infections likelihood mandatory many cases Mask Masks Measures observation period omicron Rate reduced retrospective cohort study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission School significantly higher Transmission wearing [DOI] 10.3390/ijerph192013511 PMC 바로가기
COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment managementReview article Published on 2022-10-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome addition aggravate Asymptomatic caused Characteristics chronic liver disease cirrhosis clinical clinical manifestation Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient Critical death disease dysfunction Epidemic extrapulmonary organs Factors hepatic function Hepatocellular carcinoma hypoxia immune increased risk infection with SARS-CoV-2 inflammatory factor storms Injury liver Liver damage Liver disease liver enzyme Liver function Liver injury liver transplant Liver transplantation management mechanism nonalcoholic fatty liver pathophysiological mechanism Patient patients prevalent public health reperfusion Respiratory disease risk SARS-CoV-2 severe disease Stress Treatment Vaccine [DOI] 10.1016/j.biopha.2022.113568 [Article Type] Review article
Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infectionArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] 95% CI adverse event antibody Antiviral effect ARMS clinical trial clinical trials control arm COVID-19 infection COVID-19 symptom criteria enrolled evaluated experimental arm Frequency had no healthcare worker high risk in vitro incidence rate Infection infection with SARS-CoV-2 nitazoxanide no significant difference participant PCR testing Poisson regression model positive SARS-CoV-2 PCR primary endpoint randomization Randomized randomized trial risk safety analysis SARS-CoV-2 SARS-COV-2 infection serology shown sofosbuvir/daclatasvir South Africa Symptoms the primary endpoint Treatment Trial was selected was used [DOI] 10.1093/jac/dkac266 PMC 바로가기
Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months-A Cross-Sectional StudyArticle Published on 2022-09-102022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료기술, [키워드] Administered age Anti-spike antibody approved average blood sample booster chemiluminescent immunoassay concentrations COVID-19 criterion cross-sectional elapsed elevated Epidemics exclusion health worker healthcare worker high risk hospital immunoreactivity Immunosuppression Infection infection with SARS-CoV-2 investigated Level MOST mRNA nucleocapsid protein occupational health Pandemics participant Protective required SARS-CoV-2 SARS-CoV-2 pandemic second vaccination significantly spike vaccination Vaccine worker [DOI] 10.3390/ijerph191811422 PMC 바로가기
Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccineArticle Published on 2022-09-062022-11-16 Journal: Nature Communications [Category] SARS, 변종, 치료기술, [키워드] Analysis analyzed BNT162b2 mRNA vaccine CD8 CD8+ T cell conserved COVID-19 vaccine detectable Efficacy epitope Epitopes evaluate help high affinity high stability HLA-A*24:02 immunized immunodominant epitope individual induce infection with SARS-CoV-2 long-term memory memory T cell peptide populations Prevent recognize SARS-CoV-2 SARS-CoV-2 variants second vaccination T cell T cell receptor the vaccine Vaccine variants [DOI] 10.1038/s41467-022-32989-4 PMC 바로가기
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Article Published on 2022-09-062022-11-16 Journal: Communications Biology [Category] SARS, 치료기술, [키워드] age antibodies CD4 CD8 contributing to controls convalescent disease severity eight Factor functional heterogeneity HLA HLA alleles Humoral response Icelanders induce infection with SARS-CoV-2 investigated Protein reactive SARS-CoV-2 SARS-COV-2 infection Symptom T-cell immunity T-cell Response T-cell responses the N protein uninfected [DOI] 10.1038/s42003-022-03893-w PMC 바로가기
Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccinationArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activity average characterized Cohort COVID-19 COVID-19 vaccination dose highlight humoral Humoral immunity Humoral response IgG Immunity immunologically individual Infection infection with SARS-CoV-2 infections laboratory-confirmed measure of BNT162b2 omicron Omicron variant PROTECT Protective Reinfection response SARS-CoV-2 severe disease Vaccine vaccine doses vaccine-induced immune response vaccinees variant Virus neutralization wild-type [DOI] 10.3389/fimmu.2022.947021 PMC 바로가기