innate immune response
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[용어속성] Action
[용어속성] Action
The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19
Immunology
[키워드] antiviral activity
approved
binding affinity
Cancer
classical
Clinical data
clinical trial
COVID-19
differential activity
Diseases
drug
drug candidates
Ebola
Effectiveness
experiment
form
global pandemic
hepatitis B
Heterologous
IFN-I
IFN-Is
IFNβ
Inflammation
inhibit
initial
innate immune response
Interaction
interferon
lifted
pandemic
parameter
pathogen
Pleiotropy
Protein
protein expression
receptor
reducing
role
SARS-CoV-2
severity
Signaling
specificity
Still
subtype
supported
the disease
Type
type I interferon
variety
virus
[DOI] 10.3389/fimmu.2020.595739 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.595739 PMC 바로가기 [Article Type] Immunology
Covid-19: Perspectives on Innate Immune Evasion
Immunology
[키워드] acute respiratory syndrome
Antigen presentation
approach
caused
contribute
coronavirus
Coronavirus disease 2019
cytokine - immunological terms
Cytokine storm
driving
Host
immune evasion
immune response
impair
IMPROVE
induce
Infection
Innate
innate immune response
Innate immunity
innnate immune
interferon
macropahge
mechanism
MHC class I
MHC trafficking
Mortality
outbreak
pandemic status
Pathogenesis
pathophysiology
responses
SARS-CoV-2
SARS-COV-2 infection
suppress
understanding
Vaccine
virus clearance
[DOI] 10.3389/fimmu.2020.580641 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.580641 PMC 바로가기 [Article Type] Immunology
Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy
Review
[키워드] addition
amplification
appear
approaches
circulating
circulating DNA
clinical conditions
Combination
coronavirus
correlation
COVID-19
COVID-19 pathogenesis
COVID-19 symptom
deleterious effects
disease
Diseases
DNA
drugs targeting
dysregulation
evade
Evolution
explain
Extracellular
feature
Features
hypertension
implicated
independent
Inflammation
inhibitors
innate immune response
metformin
multi-organ dysfunction
multi-organ failure
NET
NETs
neutrophil
Neutrophil extracellular trap
Neutrophil extracellular traps
offer
patho-physiology
Pathogenesis
pathogenic
peptides
Perspective
physiological
receptor
Research
Risk factors
role
SARS-CoV2
significant increase
Symptoms
tested
therapeutic strategy
Therapies
therapy
thrombosis
tissue damage
TLR
Toll-like receptor
Treatment
understanding
Vasculitis
virus entry
[DOI] 10.3390/jcm9092942 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/jcm9092942 PMC 바로가기 [Article Type] Review
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm
Review Article
[키워드] activate
acute respiratory distress
adaptive
addressed
Anti-inflammatory
ARDS
Blood
blunt
boost
bypassing
carbohydrate
Cell
cell death
central metabolism
characterized
clinical study
complex
COVID-19 patient
cytokine production
Cytokine storm
decrease
distress
downregulate
energy metabolism
enzyme
fat
Fatality rate
function
Gene Expression
GPR109A
high mortality rate
Human
immune
immune function
Immunity
include
Infection
Influenza virus
inhibit
innate immune response
ketogenic
limitation
lung cell
metabolic
mice
mitochondrial metabolism
molecular
NLRP3 inflammasome
nucleotide
outcome
oxidative damage
Patient
pDC
proliferation
PROTECT
Protective
pyruvate
raise
reactive nitrogen specy
reactive oxygen specy
redox state
responsible
risk
RNS
ROS
SARS-COV-2 infection
shown
Signaling
storm
symptom severity
syndrome
T cell proliferation
T cell response
therapy
Transport
Treatment
virus-induced cytokine storm
[DOI] 10.1155/2020/6401341 PMC 바로가기 [Article Type] Review Article
[DOI] 10.1155/2020/6401341 PMC 바로가기 [Article Type] Review Article
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Report
[키워드] acute respiratory syndrome
Analysis
association
bind
binding pocket
block
C terminus
Cell
cells
clearance
complex
complexes
coronavirus
coronavirus disease
COVID-19
disease-causing
drug
drug design
facilitate
Host
host cells
host gene expression
host protein
human cell
immune evasion
immune response
in vitro
Infection
inhibit
inhibitory
innate immune response
mechanism
Messenger RNA
Microscopy
mRNA
nonstructural protein 1
pandemic
Protein
resulting
ribosomal subunit
SARS-CoV
SARS-CoV-2
SARS-CoV-2 protein
Science
suppresse
Thom
translation
translational
treat
Viral proteins
virulence
virus
[DOI] 10.1126/science.abc8665 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abc8665 PMC 바로가기 [Article Type] Report
The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)
Review
[키워드] acute respiratory syndrome
aggregation
anti-inflammatory properties
Anti-viral therapy
Compound
coronavirus
coronavirus disease
COVID-19
COVID-19 patients
Critical
cytokine profile
Evidence
experiments
Frame
global pandemic
HMOX1
HMOX1-ORF3a
incidence
infected with SARS-CoV-2
Infection
inhibit
innate immune response
lymphopenia
Macrophage
medical condition
modulating
monocyte
mortality rates
natural compounds
ORF3a
overstimulation
pathway
Patient
Platelet
Potential treatment
prevention
Protein
recent
reduced
regulate
SARS-CoV-2
severe COVID-19
T-cell
target
Therapeutic benefit
[DOI] 10.3390/ijms21176412 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms21176412 PMC 바로가기 [Article Type] Review
The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury
Review
[키워드] Activation
Biomarker
caspase-1
characterized
Complication
consequence
different diseases
disease
Diseases
Factor
Health
highlight
Hypothesis
IL-18
IL-1β
immune response
Infection
inhibitor
Injury
innate immune response
management
neurodegenerative
Neuroinflammation
NLRP3
NLRP3 inflammasome
nonspecific
occur
potential therapeutic target
Predictive
Prognosis
pyroptosis
role
SARS-CoV-2
SARS-COV-2 infection
significantly
the SARS-CoV-2
Traumatic brain injury
upregulated
viral infections
[DOI] 10.3390/ijms21176204 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms21176204 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
Research
[키워드] ACE2
activated T cells
acute respiratory syndrome
animal model
can be used
cause
coronavirus
driven by
enzyme
evaluate
evaluated
expressing
feature
Hospitalized
Human
immune
impaired function
Infection
infiltration
innate immune response
interferon signaling
K18
K18-hACE2
K18-hACE2 mice
leukocyte activation
Lung disease
lung tissue
Lungs
mice
Monocytes
neutrophil
nuclear
occur
other organs
Pathways
phenotype
promoter
Pulmonary function
receptor
SARS-CoV-2
SARS-COV-2 infection
Severe COVID-19 Infection
severe lung inflammation
spread to
to define
transgenic mice
type I
upregulated
viral infection
viral titer
[DOI] 10.1038/s41590-020-0778-2 [Article Type] Research
[DOI] 10.1038/s41590-020-0778-2 [Article Type] Research