Neutralizing activity – Page 33 – Communicable Diseases Research

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Article

Published on 2021-08-032022-10-04
Journal: Nature Communications [Category] MERS, SARS, 변종,

[키워드] ACE2-binding site acute respiratory syndrome Analysis antibodies Antiviral bind binding binding epitope circulating variant circulating variants class comparison conserved coronavirus COVID-19 therapeutics cryo-EM structures Cryoelectron microscopy determine disrupt effective eight epitope host receptor inaccessible indicate mechanisms Microbiology Microscopy nanobody neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody neutralizing epitope potent provided RBD Receptor binding domain recognize reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Spike protein STABLE structural biology Structure target the SARS-CoV-2 unique Vaccine variant variants of concern variety virus VoC VOCs
[DOI] 10.1038/s41467-021-24963-3 PMC 바로가기 [Article Type] Article

Rational optimization of a human neutralizing antibody of SARS-CoV-2

SARS-CoV-2의 인간 중화 항체의 합리적인 최적화

Article

Published on 2021-08-012022-09-11
Journal: Computers in biology and medicine [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody Antigen binding affinities binding affinity caused contribute coronavirus coronavirus disease COVID-19 COVID-19 patients develop disrupting domain drug effective enzyme Epidemic heavy chain higher affinity host cells hydrogen Interaction molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutant mutants Mutation N501Y Neutralizing activity Neutralizing antibodies neutralizing antibody paratope residue polar interactions provide RBD RBD domain Receptor-binding domain S protein SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected patients SARS-CoV-2 S protein SARS-CoV-2 variant scanning Scanning mutageneses. single B cell single B cells the RBD the receptor-binding domain therapy
[DOI] 10.1016/j.compbiomed.2021.104550 PMC 바로가기 [Article Type] Article

Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial

Research

Published on 2021-07-302022-10-05
Journal: Nature Medicine [Category] 임상,

A functional assay for serum detection of antibodies against SARS‐CoV‐2 nucleoprotein

SARS-CoV-2 핵단백질에 대한 항체의 혈청 검출을 위한 기능적 분석

Resource

Published on 2021-07-292022-09-10
Journal: The EMBO Journal [Category] SARS, 진단, 치료기술,

A surrogate virus neutralization test to quantify antibody-mediated inhibition of SARS-CoV-2 in finger stick dried blood spot samples

손가락 스틱 건조 혈액 반점 샘플에서 SARS-COV-2의 항체-매개 억제를 정량화하기위한 대리 바이러스 중화 시험

Article

Published on 2021-07-282022-09-01
Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 agreement Analysis angiotensin antibodies Antigen Blood blood collection can be used Coefficient of variation collected Concordance control sample convalescent COVID-19 COVID-19 sample DBS sample DBS samples dilution series dilution sery effective engage enzyme expand expected Filter Paper General population host cells human Angiotensin-converting enzyme Immunity immunoassay Immunological techniques incubated indicated Infection Interaction Large-scale testing Live virus marker measure neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody PCR phase plate populations positive Precision Prevent produced protective immunity provide receptor reliability Sample SARS-CoV-2 serum serum samples solid phase Spike protein stick surrogate Variation venous venous blood virus neutralization test Whole blood
[DOI] 10.1038/s41598-021-94653-z PMC 바로가기 [Article Type] Article

Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C

COVID-19 변종 CAL.20C의 면역 혈청의 감염력 및 중화 활성에 대한 영향 평가

Comment

Published on 2021-07-272022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단,

[키워드] assessment CAL.20C COVID-19 immune Infectious diseases Neutralizing activity sera variant
[DOI] 10.1038/s41392-021-00695-0 PMC 바로가기 [Article Type] Comment

Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner

Research Article

Published on 2021-07-272022-10-29
Journal: mBio [Category] COVID-19, SARS,

SARS-CoV-2 Infection in Dogs and Cats from Southern Germany and Northern Italy during the First Wave of the COVID-19 Pandemic

Covid-19 Pandemic의 첫 번째 물결 동안 독일 남부 및 이탈리아 북부의 개와 고양이에서 SARS-COV-2 감염

Communication

Published on 2021-07-262022-09-10
Journal: Viruses [Category] SARS, 치료기술, 치료제,

[키워드] (RdRp 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus affected analyzed animal anti-SARS-CoV-2 antibody cats Chain Reaction clinics coronavirus coronavirus disease COVID-19 dog domestic animals First wave Genes Germany highlighting hotspot humans Hypothesis incidence Italian Italy Laboratory lombardy nasal swab Neutralizing activity one health Oropharyngeal oropharyngeal swab pandemic patients Piedmont polymerase chain polymerase chain reaction populations positive Prevalence qPCR RBD RdRP Receptor binding domain recruited Region respiratory Respiratory disease reverse transcriptase risk RNA RNA polymerase RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sera Serologically serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specimen Support Surveillance susceptible tested transcriptase Viral viral envelope Wave zoonosis zoonotic transmission
[DOI] 10.3390/v13081453 PMC 바로가기 [Article Type] Communication

Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants

Article

Published on 2021-07-262022-10-04
Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘,

Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study

COVID-19 환자에서 항체의 동적 특성 분석: 13개월 연구

Immunology

Published on 2021-07-202022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antibody Antibody Response characteristic collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 described detective domain dynamic early stage effective Extracellular Hospitalized IgA level IgA levels IgM Immunity Immunoglobulin immunoreaction Infection Neutralizing activity Neutralizing antibodies nucleocapsid protein observation offered onset of symptom Patient POS Postinfectious quantified reaction Receptor binding domain Receptor-binding domain remained respiratory SARS-CoV-2 SARS-CoV-2 spike Screen serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein target targets vaccination worldwide pandemic
[DOI] 10.3389/fimmu.2021.708184 PMC 바로가기 [Article Type] Immunology