Effect of hydroxychloroquine pre-exposure on infection with SARS-CoV-2 in rheumatic disease patients: a population-based cohort study류마티스 질환 환자의 SARS-CoV-2 감염에 대한 하이드록시클로로퀸 사전 노출의 영향: 인구 기반 코호트 연구Article Published on 2021-04-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Arthritis assessment attack rate Clinical data conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 in patient determine disease Effect HCQ HCQ therapy Health Insurance HIRA Hydroxychloroquine in vitro study infection with SARS-CoV-2 infections insurance investigated Korean logistic regression models lupus erythematosus MOST not differ Patient population-based cohort pre-exposure prophylaxis Prevent Prophylactic retrospective cohort study review rheumatic disease Rheumatic diseases rheumatoid arthritis SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SLE student suggested systemic lupus erythematosus T-tests tested treated Treatment Usual dose [DOI] 10.1016/j.cmi.2020.12.003 PMC 바로가기 [Article Type] Article
Impact of COVID-19 lockdown on suicide attempts A retrospective analysis of the springtime admissions to the trauma resuscitation room at the Medical University of Vienna from 2015–2020Original Article Published on 2021-03-312022-10-29 Journal: Wiener Klinische Wochenschrift [Category] Coronavirus, SARS, [키워드] Admission Affect Analysis assumption Attempted suicide average caused control group coronavirus disease Coronavirus lockdown COVID-19 COVID-19 pandemic demographic emotional Evidence excluded Government groups healthcare hospital Impact increase in Injury Intervention lockdown measure Mental not differ pandemic Patient patient data patients treated Polytrauma psychological health replaced Result resulting Suicide attempts during lockdown suicide prevention the study group trauma university Vienna [DOI] 10.1007/s00508-021-01839-6 PMC 바로가기 [Article Type] Original Article
Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3 + CD8 + T-cell lymphocytopenia in COVID-19 patients without comorbidities on admissionCOVID-19 이환율 통계의 연령 분포에 따라 계층화된 연령 집단은 입원 시 동반 질환이 없는 COVID-19 환자에서 고유하게 연령 의존적 CD3 + CD8 + T 세포 림프구감소증을 식별합니다Research Paper Published on 2021-03-312022-08-31 Journal: Aging (Albany NY) [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age age distributions age-dependent immune features Analysis B cell C-reactive protein C-reactive protein concentration can be used CD3 CD4 CD8 CD8+ T cells cell count Cohort Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients defined develop distribution feature FIVE help identify immune indicated Infection Killer cell lymphocyte Lymphocyte count lymphocyte counts Lymphocyte subsets lymphocytopenia lymphopenia morbidity morbidity statistics natural killer natural killer cell not differ Pathogenesis patients plasma respiratory Retrospective study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significantly Statistics stratified susceptibility T cell T cells T-cell the disease Therapeutic strategies therapeutic strategy [DOI] 10.18632/aging.202691 PMC 바로가기 [Article Type] Research Paper
Impact of hydroxychloroquine on disease progression and ICU admissions in patients with SARS-CoV-2 infectionObservational Study Published on 2021-03-312022-10-05 Journal: American journal of health-system pharmacy : AJHP [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval Admission age association Care Community conducted coronavirus coronavirus disease COVID-19 determine diabetes diagnosis of SARS-CoV-2 Disease progression disease severity evaluate Gender hospital Hudson Valley Hydroxychloroquine ICU ICU admission Impact increased risk Infection intensive care interquartile range Intubated intubation laboratory-confirmed likelihood median Mild moderate Mortality multivariable model New York not differ obesity Observational cohort study Odds ratio pandemic Patient patients hospitalized patients with SARS-CoV-2 receive reduced retrospective selected severe symptom significantly significantly more transferred treated Treatment outcome use of hydroxychloroquine with COVID-19 [DOI] 10.1093/ajhp/zxab056 PMC 바로가기 [Article Type] Observational Study
Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial단순 COVID-19 외래 환자 치료를 위한 Peginterferon Lambda-1a: 무작위 위약 대조 시험Randomized Controlled Trial Published on 2021-03-302022-08-13 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 95% CI 95% confidence interval conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine Diagnosis Effect Elevation group hazard ratio IMPROVE interferons Lambda liver transaminase median time Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 NCT04331899 not differ Outpatient outpatients outpatients with uncomplicated Patient Peginterferon Lambda-1a Placebo placebo-controlled trial primary endpoint Randomized Randomized controlled trials randomized placebo-controlled trial receiving resolved SARS-CoV-2 viral shedding secondary endpoint significantly single dose single-blind subcutaneous dose Symptom symptom duration Symptoms the median Therapeutics Treatment Trial type III interferon Type III interferons Viral viral infection viral shedding [DOI] 10.1038/s41467-021-22177-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impact of COVID-19 on the oral health of adults in Wuhan and China: results of a nationwide online cross-sectional questionnaire surveyResearch Article Published on 2021-03-262022-10-28 Journal: BMC Oral Health [Category] COVID-19, Fulltext, SARS, [키워드] affected bleeding breath Care China collected conducted COVID-19 cross-sectional cross-sectional survey evaluate Frequency gingival bleeding Health Impact maintaining not differ oral health participant Prevalence problem problems psychologically question questionnaire Questionnaire survey Result significantly significantly more suffered supplementary material the epidemic toothbrushing Treatment Wuhan [DOI] 10.1186/s12903-021-01533-z PMC 바로가기 [Article Type] Research Article
A faster and less costly alternative for RNA extraction of SARS-CoV-2 using proteinase k treatment followed by thermal shock열 충격 후 proteinase k 처리를 사용하여 SARS-CoV-2의 RNA 추출을 위한 더 빠르고 저렴한 대안Research Article Published on 2021-03-242022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료제, [키워드] addition alternative method average conducted costly COVID-19 Critical Ct values decrease detect diagnose Effectiveness epidemiological experiment faster followed by house initial INS Internal control lack less measure molecular Molecular diagnosis Molecular tests not differ pandemic Patient proteinase Proteinase K protocol reagents real time RNA RNA extraction RT-PCR RT-PCR reaction RT-PCR reactions SARS-CoV-2 SARS-COV-2 infection Shock significantly submitted targets tested the disease the SARS-CoV-2 Treatment Viral virus spread [DOI] 10.1371/journal.pone.0248885 PMC 바로가기 [Article Type] Research Article
Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort studyResearch Paper Published on 2021-03-232022-10-30 Journal: The Lancet Regional Health - Europe [Category] COVID-19, [키워드] 95% CI 95% confidence interval adjusted age analysed association average Community Deprivation finding funding groups incidence Logistic regression MONITOR multivariable not differ Odds ratio pandemic participant Prevalence prospective cohort study pupil Pupils Quantitative Region robust RT-qPCR SARS-COV-2 infection School the SARS-CoV-2 [DOI] 10.1016/j.lanepe.2021.100086 PMC 바로가기 [Article Type] Research Paper
The Impact of the COVID-19 Pandemic on Vulnerable People Suffering from Depression: Two Studies on Adults in FranceArticle Published on 2021-03-212022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] addition Anxiety boredom compensated COVID-19 COVID-19 pandemic Depression depressive symptom Effect emotion France French greater groups Health Impact investigated large sample less lockdown Mental mental health Mild moderate not differ pandemic participant Psychological psychologically Psychology public health questionnaire Result risk sleep quality smoking social isolation suffered suffering Supporting survey Symptoms [DOI] 10.3390/ijerph18063250 PMC 바로가기 [Article Type] Article
On the SARS-CoV-2 “Variolation Hypothesis”: No Association Between Viral Load of Index Cases and COVID-19 Severity of Secondary CasesMicrobiology Published on 2021-03-162022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 2019 novel coronavirus acute respiratory syndrome Amedeo Clinical outcome clinical picture collected Contact Coronavirus-2 COVID-19 COVID-19 case COVID-19 emergency cross-sectional study cut-off cycle threshold death Deceased defined diagnosed Diagnosis disease disease severity Evidence exploratory Hospitalization Hospitalized household contact index index case index cases Infection load male median median age Microbiology nasal-pharyngeal swab negative not differ outcomes PCR cycle pediatric Piedmont platform predict presenting Prevalence public health quantification Randomly RdRp gene SARS-CoV-2 SARS-CoV-2 RNA secondary secondary case secondary cases secondary infections Support survived Swab Symptom symptomatic symptomatic and asymptomatic symptomatic infection symptomatic infections tested the SARS-CoV-2 threshold Turin viral amount viral inoculum Viral load [DOI] 10.3389/fmicb.2021.646679 PMC 바로가기 [Article Type] Microbiology