Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers A Randomized Clinical Trial
의료 종사자의 사전 노출 SARS-CoV-2 예방을 위한 하이드록시클로로퀸 대 위약의 효능 및 안전성 무작위 임상 시험
Randomized Controlled Trial
[키워드] 95% CI
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Administered
adverse effects
adverse event
Arm
ARMS
Asymptomatic
baseline
Care
clinical
clinical benefit
Clinical outcome
clinical outcomes
clinical trial
clinically
cohorts
conducted
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
detect
determined by
double-blind
effective
Efficacy
Enrollment
evaluate
exposure to
finding
Follow-up
Frequency
futility
HCW
HCWs
Health
Health care
Health care worker
health care workers
hospital
Hospitalization
hospitals
Hydroxychloroquine
Identifier
Importance
incidence
individual
infection rate
infection rates
knowledge
measure
median
median age
Nasopharyngeal swab
no significant difference
not differ
Nurses
objective
outcome
participant
Participants
Patient
patients with COVID-19
per day
pharmacologic prophylaxis
Philadelphia
Physicians
Placebo
placebo-controlled
placebo-controlled clinical trial
Point
polymerase chain
positive result
Prevent
prevention
Primary outcome
Prophylaxis
prophylaxis strategy
QTc
QTC prolongation
Randomized
randomized clinical trial
receive
reduce
regimen
Registration
Relevance
required
respiratory
Result
reverse-transcriptase polymerase chain reaction
risk
Safety
SARS-CoV-2
SARS-CoV-2 antibodies
SARS-COV-2 infection
SARS-CoV-2–positive
secondary
Secondary outcomes
setting
severe acute respiratory syndrome Coronavirus
significant difference
Transmission
transmission of SARS-CoV-2
Treatment
Trial
Trial registration
Viral
women
worker
[DOI] 10.1001/jamainternmed.2020.6319 PMC 바로가기 [Article Type] Randomized Controlled Trial
[DOI] 10.1001/jamainternmed.2020.6319 PMC 바로가기 [Article Type] Randomized Controlled Trial