Prediction of hospital bed capacity during the COVID− 19 pandemicResearch Article Published on 2021-05-182022-10-28 Journal: BMC health services research [Category] Coronavirus, SARS, [키워드] Admitted Patient changes in code COVID− 19 death discharge Epidemics Ghent hospital Hospital data Hospital wards ICU less methodology Multistate modeling pandemic Patient Poisson model Poisson modelling prediction provided required Result supplementary material university were used [DOI] 10.1186/s12913-021-06492-3 PMC 바로가기 [Article Type] Research Article
Prediction and Evolution of the Molecular Fitness of SARS-CoV-2 Variants: Introducing SpikeProArticle Published on 2021-05-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Accuracy ACE2 receptor Amino acid Characteristics circulating Clinical data COVID-19 Critical deep mutagenesis dominant driving epidemiological Evolution example fitness genomic human immune response identify Immune escape molecular mechanism Neutralizing antibodies population level predict predicted prediction protein binding affinity protein stability SARS-CoV-2 sequence Spike protein variants stability Surveillance the binding affinity the SARS-CoV-2 the SARS-CoV-2 virus the spike protein time-consuming Transmissibility variant viral fitness viral strain viral strains virus [DOI] 10.3390/v13050935 PMC 바로가기 [Article Type] Article
Machine Learning Based Clinical Decision Support System for Early COVID-19 Mortality PredictionPublic Health Published on 2021-05-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate Accuracy acute respiratory disease age Analysis Biomarker Biomarkers Blood blood test caused clinical Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CT-scans decision determine FIVE form Healthcare system Healthcare systems help high accuracy high mortality rate High-sensitivity C-reactive protein identify Infection key factor lactate dehydrogenase LDH Logistic regression Lymphocytes machine learning medical treatment ML model Mortality Neutrophils outcome pandemic patient treatment practicality predict prediction Predictive Prognosis random risk SARS-CoV-2 SVM System the disease virus was performed WHO World Health Organization [DOI] 10.3389/fpubh.2021.626697 PMC 바로가기 [Article Type] Public Health
Prediction of daily and cumulative cases for COVID-19 infection based on reproductive number (R 0 ) in Karnataka: a data-driven analyticsArticle Published on 2021-05-122022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 95% CI applied assumption bootstrap Computational biology and bioinformatics coronavirus COVID-19 COVID-19 infection COVID-19 outbreak cumulative data-driven dependent on distribution Epidemic expected growth Health care hospital incidence India maximum-likelihood median Microbiology outbreak package in R Poisson distribution predict prediction random reproductive trajectory was performed would increase [DOI] 10.1038/s41598-021-89573-x PMC 바로가기 [Article Type] Article
Fast Prediction of Binding Affinities of the SARS-CoV-2 Spike Protein Mutant N501Y (UK Variant) with ACE2 and Miniprotein Drug CandidatesSARS-CoV-2 스파이크 단백질 돌연변이 N501Y(영국 변이체)와 ACE2 및 미니단백질 약물 후보의 결합 친화도에 대한 빠른 예측Article Published on 2021-05-062022-09-11 Journal: The journal of physical chemistry. B [Category] MERS, SARS, 변종, 치료제, [키워드] ACE2 affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach B.1.1.7 bind binding binding affinities binding affinity binding free energies binding free energy calculated candidate complex creating decrease demonstrated drug drug candidates drug resistance experimental structure explain free energies free energy Free energy calculations hACE2 host cells human ACE2 identified variant increase Lineage Lineage B.1.1.7 miniprotein mutant N501Y N501Y mutation overcome predict predicted prediction Protein Protein binding reported SARS-CoV-2 spike protein SARS-CoV-2 virus spike Spike protein the binding affinity the SARS-CoV-2 the spike protein therapeutic United Kingdom variant Viral viral entry [DOI] 10.1021/acs.jpcb.1c00869 PMC 바로가기 [Article Type] Article
Prediction of Re-positivity for Coronavirus Nucleic Acid Among COVID-19 Patients in the Recovery PhaseMedicine Published on 2021-05-052022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval acid Asymptomatic body temperature characteristic China coronavirus disease coronavirus nucleic acid COVID-19 COVID-19 patient cured discharge effective epidemiological data evaluated extension feasible Hospital stay independent risk factor Logistic regression analysis median time multivariate nucleic acid Pathogenesis patients phase positive prediction predictor quarantine re-emergence of coronavirus nucleic acids Re-positivity recovered patient risk risk predication ROC ROC Curve treated Treatment virus nucleic acid Zhongxiang [DOI] 10.3389/fmed.2021.620727 PMC 바로가기 [Article Type] Medicine
Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19Article Published on 2021-05-052022-10-04 Journal: Scientific Reports [Category] SARS, 임상, 치료제, [키워드] alleviate analyzed anti-inflammatory agents anti-inflammatory drug approach approved binding affinity Biotechnology Cell Clinical efficacy Computational biology and bioinformatics Coronavirus disease 2019 COVID-19 docking score drug enrichment analysis excessive inflammation exhibited FDA food genetics Health care highest indomethacin inhibition KEGG Kyoto MAPK10 MAPK8 mechanism Medical research Molecular biology molecular docking network network pharmacology NSAID NSAIDS overlapping Pathway enrichment analysis Patient prediction proinflammatory Protein PubChem RAS Rofecoxib RStudio SARS-CoV-2 selected signaling pathway target target protein target proteins the binding affinity tissue Venn diagram was determined were used [DOI] 10.1038/s41598-021-88313-5 PMC 바로가기 [Article Type] Article
How well did experts and laypeople forecast the size of the COVID-19 pandemic?Research Article Published on 2021-05-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] Accuracy addition asked calibrated conducted COVID-19 COVID-19 pandemic epidemiologist exhibited expected expert greater interval magnitude media outcome pandemic participant point estimates prediction Quantitative quartile scored subset the mean [DOI] 10.1371/journal.pone.0250935 PMC 바로가기 [Article Type] Research Article
Prediction of COVID-19 Hospital Length of Stay and Risk of Death Using Artificial Intelligence-Based ModelingMedicine Published on 2021-05-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome analyzed Anticoagulant approach artificial artificial intelligence Clinical data clinical information coronavirus COVID-19 COVID-19 case COVID-19 cases death deviation Dexamethasone Dubai effective ENhance Health authority Healthcare systems high risk Hospital stay indicated Infectious virus International intubated COVID-19 patient intubated patient Length Length of stay management median medication medications modeling normalized Patient physician predict prediction Predictive Predictive analytics Predictive model R 2 Receiver operator characteristic reported risk of death robust SARS-CoV-2 Sensitivity and specificity suggested the patient [DOI] 10.3389/fmed.2021.592336 PMC 바로가기 [Article Type] Medicine
Prediction of lopinavir/ritonavir effectiveness in COVID-19 patients: a recall of basic pharmacology conceptsCOVID-19 환자에서 로피나비르/리토나비르 효과 예측: 기본 약리학 개념의 회상Comment Published on 2021-05-012022-09-11 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] COVID-19 Effectiveness prediction recall [DOI] 10.1007/s00228-020-03053-1 PMC 바로가기 [Article Type] Comment