The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and ImmunometabolismReview Published on 2022-01-302022-10-31 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] absence adipose anti-inflammatory effect anti-inflammatory macrophage characterized COVID-19 Defense demonstrated Effect excessive inflammatory response Immunocompromise immunometabolism individual Infection Inflammation Inflammatory Inflammatory diseases Inflammatory response influence inherent innate response Intervention Loss low-grade inflammation Macrophage macrophages obese obesity pathogen question reduction in Research response responses Result susceptibility tissue viral infections weight weight loss [DOI] 10.3390/nu14030612 PMC 바로가기 [Article Type] Review
Competitive Endogenous RNA Network Activates Host Immune Response in SARS-CoV-2-, panH1N1 (A/California/07/2009)-, and H7N9 (A/Shanghai/1/2013)-Infected Cells경쟁적인 내인성 RNA 네트워크는 SARS-CoV-2-, panH1N1(A/California/07/2009) 및 H7N9(A/Shanghai/1/2013)에 감염된 세포에서 숙주 면역 반응을 활성화합니다Article Published on 2022-01-302022-09-11 Journal: Cells [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 치료기술, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Apoptosis autophagy Avian Influenza binding Cell cellular coronavirus Coronaviruses downregulated gene endogenous expression H1N1 H7N9 Hope host cell host cells in viral indicated infected cells Infection Influenza influenza A influenza A virus influenza A viruses Influenza virus inhibit Interaction involved IRF1 IRF1 mRNA lncRNA metabolic pathways molecular mechanism molecular mechanisms mRNA network noncoding RNA Other outbreak p53 p53 signaling pathway pandemic pathogenicity pathway pertussis provide Regulation Research respiratory respiratory virus response responsible RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2- severe acute respiratory syndrome Coronavirus signaling pathway susceptibility therapeutic agent therapeutic agents these viruses three group three groups Transcriptome Tuberculosis unique upregulated upregulated gene upregulation Viral viral pathogenicity virus viruses [DOI] 10.3390/cells11030487 PMC 바로가기 [Article Type] Article
A Peek into Pandora’s Box: COVID-19 and NeurodegenerationReview Published on 2022-01-302022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] accelerate ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 association Biomarker Brain Central nervous system changes CNS Comorbidity coronavirus COVID-19 current disease disease severity distress Effects gastrointestinal system hypoxia indirect effect individual induce mechanism Mitochondria molecular biology technique neurodegeneration neurodegenerative Neuron organ systems oxidative stress Proinflammatory cytokine provide pulmonary complications receptor renal reported SARS-CoV-2 SARS-COV-2 infection surviving patients susceptibility susceptible therapeutic Therapeutics Vaccine development Variability variant virus virus attack Wuhan, China [DOI] 10.3390/brainsci12020190 PMC 바로가기 [Article Type] Review
Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection [DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology
Humoral response to the SARS-CoV-2 BNT162b2 mRNA vaccine: Real-world data from a large cohort of healthcare workersSARS-CoV-2 BNT162b2 mRNA 백신에 대한 체액 반응: 대규모 의료 종사자 집단의 실제 데이터Article Published on 2022-01-282022-09-12 Journal: Vaccine [Category] SARS, 진단, [키워드] accelerated age Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-Spike IgG antibody Blood BNT162b2 mRNA CMIA cohorts COVID-19 death determine elevated ENCODE Factor group groups healthcare healthcare worker humoral immune response Humoral immunity Humoral response IgG IgG antibody immune response immunological increase in independent large cohort median titer men Messenger RNA mRNA vaccine multivariate logistic regression participant pre-vaccination RBD real-world data Receptor binding domain reduction responsible S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 pandemic significantly Support susceptibility tested the SARS-CoV-2 the spike protein timepoints titer vaccination Vaccine Vaccines virus was collected women [DOI] 10.1016/j.vaccine.2021.12.014 PMC 바로가기 [Article Type] Article
Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19Full Papers Published on 2022-01-282022-10-28 Journal: The British Journal of Nutrition [Category] COVID-19, [키워드] Adhesion Molecule alteration approved association cell death cell type Clinical data Corona Corona Virus Disease 19 COVID-19 deaths decrease deficiency detrimental disease dysfunction Effect effective function Health health system homoeostasis immune functions immune response immune system impaired immune system increase Increases Infection likelihood metabolism Mild Mild symptom Organ failure overactive pathogen pathogenic mechanism Patient phenotype Prevent problem progression proinflammatory Protein reduce Registered respiratory resulting risk factor severe acute respiratory syndrome-coronavirus-2 Severe case susceptibility therapeutic option tissue tissue damage Vaccine while with COVID-19 zinc deficiency [DOI] 10.1017/S0007114521000738 PMC 바로가기 [Article Type] Full Papers
Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19Physiology Published on 2022-01-272022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] abnormality addition Asymptomatic Asymptomatic carrier baseline carrier Cohort Compound Concentration COVID-19 COVID-19 infection COVID-19 pandemic demonstrated drug Duration early phase ECG Effect Efficacy electrical field HCQ healthy healthy donors Hydroxychloroquine identify IMPROVE in vitro induced pluripotent stem cells inhibiting investigated Long Long QT syndrome Mutation Patient patients pharmacological interventions populations Potential Precision precision medicine Prognosis QT interval Replication rule safety pharmacology SARS-CoV-2 SARS-COV-2 infection silent susceptibility symptomatic symptomatic patient translational treat variant while [DOI] 10.3389/fphys.2021.730127 PMC 바로가기 [Article Type] Physiology
Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral AdiposityNutrition Published on 2022-01-262022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 95%CI Adipose tissue adjusted age association BMI body-mass clinical evaluation Computerized tomography contribute COVID-19 COVID-19 mortality Critical D-dimer Deficient defined disease evaluated examined fat Follow-up global pandemic Increased increased risk independent independent of Infectious disease laboratory measurement Level Mediation analysis Mexico City Mortality outcome outcomes Patient pro-inflammatory pro-thrombotic Result risk SARS-CoV-2 severe COVID-19 Sex susceptibility Thoracic visceral Vitamin D vitamin D deficiency vitamin D level with COVID-19 [DOI] 10.3389/fnut.2022.813485 PMC 바로가기 [Article Type] Nutrition
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2Article Published on 2022-01-252022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] ACE2 acute infection Acute inflammation Affect airway airways alveolar macrophage Alveolar macrophages ambient analyzed Angiotensin-converting enzyme binding cause cellular receptor clinical settings collected correlated dependent on detrimental effect elevated Environmental impact Epidemiology expression expression level health emergency Host host cell host susceptibility individual Infection Interaction lung tissue mice morbidity and mortality Mortality pandemic Pathogenesis priming proportion protease Protein proteolytic respiratory tract SARS-CoV-2 SARS-CoV-2 entry Scientific community serine 2 severe disease severe SARS-CoV-2 severity shown significantly subsequent susceptibility the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transcript transmembrane upregulate upregulated virus while [DOI] 10.1038/s41598-022-04906-8 PMC 바로가기 [Article Type] Article
Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over TimeResearch Article Published on 2022-01-252022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Analysis anti-spike IgG level antibody Antibody Response B.1 lineage Beta breadth circulating variant collected convalescent individuals coronavirus disease COVID-19 cross-neutralizing Delta escape examined Gamma increase in indicate Lambda Lineage Local longitudinal neutralization neutralizing antibody neutralizing capacity observation postvaccination receiving recent reduction SARS CoV-2 SARS-CoV-2 SARS-CoV-2 variant Serum neutralizing antibody serum sample show shown significantly Sputnik V susceptibility time vaccination Vaccine variant variants variants of concern viral variant Viral variants virus VoC Volunteer were used Wuhan [DOI] 10.1128/mbio.03442-21 PMC 바로가기 [Article Type] Research Article