Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway
Article
[키워드] adipose
Alter
blood glucose
CD11c
change
Chemokine receptor
Complication
complications
condition
confocal microscopy
correlated
Critical
downstream
drive
ELISA
expression
flow cytometry
fluctuation
Gene Expression
Glucose
Glucose fluctuation
glucose fluctuations
glycemic control
hemoglobin
homeostatic
hyperglycemia
hypoglycemia
IL-1β
IL-6
independent risk factor
individuals
Inflammation
Inflammatory
Inflammatory marker
Inflammatory response
insulin resistance
Intensive
interferon regulatory factor
Intermittent
Involving
IRF5
Macrophage
macrophages
marker
matrix metalloproteinase
mechanism
metabolic inflammation
monocyte
monocytes/macrophages
motif
Necrosis
occur
pathway
Patient
patients
polarization
promote
Protein
qRT-PCR
repetitive intermittent hyperglycemia
response
RNA
siRNA
T2D
therapy
THP-1
tissue sample
TLR4
TNF-α
Toll-like receptor
Transcription
type-2 diabete
type-2 diabetes
western blotting
[DOI] 10.3390/cells9081892 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/cells9081892 PMC 바로가기 [Article Type] Article