D614G – Page 34 – Communicable Diseases Research

An Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular Diagnostics in Benin, Western Africa

서아프리카 베냉에서 SARS-CoV-2 분자 진단에 대한 관찰 실험실 기반 평가

Observational Study

Published on 2021-01-132022-09-10
Journal: mSphere [Category] MERS, 변종, 임상, 진단, 치료기술, 치료제,

Impact of population density and weather on COVID-19 pandemic and SARS-CoV-2 mutation frequency in Bangladesh

방글라데시에서 인구 밀도와 날씨가 COVID-19 전염병 및 SARS-CoV-2 돌연변이 빈도에 미치는 영향

Original Paper

Published on 2021-01-072022-09-11
Journal: Epidemiology and Infection [Category] 변종,

An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets

Database

Published on 2021-01-072022-10-31
Journal: Genome Medicine [Category] COVID-19,

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

SARS-CoV-2 스파이크 돌연변이 D614G가 전염성과 병원성에 미치는 영향 평가

Article

Published on 2021-01-072022-09-11
Journal: Cell [Category] MERS, SARS, 변종,

[키워드] age Analysis approach association Clinical severity Cluster COVID-19 COVID-19 mortality D614G dataset dispersal Effect Epidemiology Evaluating Evolution founder effect Frequency genetic analysis greater growth Hypothesis increases in Increasing indicate Mortality mutation D614G Patient patient age patients phylogenetic cluster Population Population genetic analysis Positive selection random SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 sequences selective Severity of infection Significant significant differences significantly spike Spike protein Spread the SARS-CoV-2 United Kingdom variant variants Viral Viral load whole genome younger patient younger patients
[DOI] 10.1016/j.cell.2020.11.020 PMC 바로가기 [Article Type] Article

A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351

붉은 털 원숭이에서 SARS-CoV-2에 대한 강력한 효능의 인간 항체는 B.1.351에 대한 강력한 차단 활성을 나타냈습니다

Article

Published on 2021-01-012022-09-11
Journal: mAbs [Category] MERS, 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody B.1.1.7 B.1.351 binding blocking activity broad-spectrum cause clinical trial Complete convalescent plasma coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 pandemic D614G demonstrated disease Efficacy hACE2 host cell host cell receptor in vitro Infection interact Intervention JMB2002 lead neutralization Neutralizing Neutralizing antibodies neutralizing antibody phage phage-to-yeast Phase 1 Phase 1 clinical trial platform Prophylactic Protein RBD Receptor binding domain respiratory rhesus rhesus macaque rhesus macaque disease model. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the RBD the SARS-CoV-2 therapeutic therapeutic efficacy Transmission Vaccine virus yeast
[DOI] 10.1080/19420862.2021.1930636 PMC 바로가기 [Article Type] Article

Comments on ‘Development of a PCR-RFLP method for detection of D614G mutation in SARS-CoV-2’

'SARS-CoV-2에서 D614G 돌연변이 검출을 위한 PCR-RFLP 방법 개발'에 대한 논평

Comment

Published on 2021-01-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술,

[키워드] Abstract Comment D614G D614G mutation development Iran method Mutation SARS CoV SARS CoV-2 SARS-CoV-2 V615L V615V.
[DOI] 10.1016/j.meegid.2020.104661 PMC 바로가기 [Article Type] Comment

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

무료 SARS-CoV-2 스파이크 단백질 S1 입자는 COVID-19 감염의 병인에서 역할을 할 수 있습니다

Hypothesis

Published on 2020-12-302022-09-01
Journal: Biochemistry. Biokhimiia [Category] SARS, 변종, 진단,

[키워드] accompanied ACE ACE2 angiotensin angiotensin (1-7) Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 association caused Cell cell surface circulation cleavage site COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis D614G D614G mutation decrease disease downregulate downregulated Effect expression fraction Free furin furin protease higher infectivity Hypothesis Imbalance in vivo infected cell infected cells Infection Inflammation investigated lack lead less lung Lungs membrane-bound murine model mutant natural infection Particle Pathogenesis pathogenesis of COVID-19 Prevalence Protein pulmonary damage receptor-binding domains Recombinant spike protein Renin renin-angiotensin system reported role S protein S1 and S2 S1 subunit S1 subunit shedding SARS-CoV virus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 strain separation severity shown spike Spike protein subunits the cell the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 thrombosis trimer unlikely Viral Viral load virion virions wild type
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

Article

Published on 2020-12-262023-06-15
Journal: Cell Reports [Category] MERS, SARS,

[키워드] 2P Allostery COVID-19 cryo-EM D614G furin cleavage SARS-CoV-2 spike
[DOI] 10.1016/j.celrep.2020.108630 PMC 바로가기 [Article Type] Article

Loss of orf3b in the circulating SARS-CoV-2 strains

Research Article

Published on 2020-12-242022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, SARS,

[키워드] addition Alter amino acids analysed Analysis Betacoronavirus cause caused circulating Complete Continuous country COVID-19 pandemic D614G D614G substitution death ENhance Evolution France full-length functional Genome help human infection Laboratory Loss loss of function nine Non-synonymous notable ORF3a ORF3b prevalent Protein Q57H reached SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strain SARS-CoV-2 strains Saudi Arabia South Korea stop codon Substitution the interferon Transmissibility Transmission USA viral adaptation viral genome viral pathogenesis viral strain virulence virus
[DOI] 10.1080/22221751.2020.1852892 PMC 바로가기 [Article Type] Research Article

Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation

SARS-CoV-2 스파이크 D614G 돌연변이의 진화 역학에 대한 ACE2 발현의 유전적 다양성의 영향

Communication

Published on 2020-12-242022-09-10
Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] absence ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African angiotensin Antiviral treatment Asian binding China circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D 614G D614G D614G mutation D614G variant domain driving dynamic Dynamics Efficiency enzyme Europe European Evolution Evolution of SARS-CoV-2 fusion genetic diversity Genetic variation genetics glycoprotein human population idea Impact increase in measure Mutation North North America open pandemic Population Population genetics populations Positive selection predominant public health RBD respiratory Result S glycoprotein SARS-CoV-2 selective pressure selective pressures severe acute respiratory syndrome Coronavirus spike Support the SARS-CoV-2 Transmissibility Transmission understanding variant Variation variations Viral viral evolution
[DOI] 10.3390/genes12010016 PMC 바로가기 [Article Type] Communication