Drug repurposing – Page 34 – Communicable Diseases Research

Peptide-like and small-molecule inhibitors against Covid-19

Covid-19에 대한 펩티드 유사 및 소분자 억제제

Article

Published on 2021-05-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제,

[키워드] approach approved drugs binding energy binding site carried clinical trials co-crystallized Cobicistat Compound coronavirus disease COVID-19 darunavir database dead disease docked docking docking score docking scores drug Drug repurposing FDA approved drug FDA approved Drugs globe identify in-silico individual inhibitor Interaction interactions Ligand Lopinavir MD simulation MD simulations molecular dynamics Molecular mechanics molecules PDB PDB structure performed positive Potential Protease inhibitor protease inhibitors Protein Protein Data Bank reported Ritonavir SARS-CoV-2 screened Screening selected stability Structure surface area the disease Virtual screening Zinc ZINC database
[DOI] 10.1080/07391102.2020.1757510 PMC 바로가기 [Article Type] Article

An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS-CoV-2 Main Protease

SARS-CoV-2 주요 프로테아제의 잠재적 억제제 식별을 위한 통합 in silico 약물 용도 변경 접근법

Article

Published on 2021-05-012022-08-31
Journal: Molecular informatics [Category] SARS, 신약개발, 치료제,

A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing

약물 용도 변경을 위한 표적을 찾기 위한 SARS-CoV-2(COVID-19) 생물학적 네트워크

Article

Published on 2021-04-302022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 임상, 치료기술, 치료제,

Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus

SARS-CoV-2 코로나바이러스의 핵단백질을 표적으로 하는 NSAID 약물 나프록센의 항바이러스 특성

Article

Published on 2021-04-292022-09-10
Journal: Molecules [Category] SARS, 신약개발, 치료제,

[키워드] active against addition anti-inflammatory drug anti-inflammatory properties Antiviral antiviral properties antiviral property Antiviral treatment binding Celecoxib clinical setting clinical study coronavirus COVID-19 demonstrated drug Drug repurposing epithelia evaluated fluorescence anisotropy form function infected cells Inflammation Influenza influenza A influenza A virus inhibited inhibitor molecular naproxen nucleoprotein oligomerization pandemic Paracetamol predicted Prevent property respiratory respiratory epithelium SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection scattering Standard of care Structure-based drug design targeting tested the SARS-CoV-2 VeroE6 cell VeroE6 cells Viral viral replication virus
[DOI] 10.3390/molecules26092593 PMC 바로가기 [Article Type] Article

Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)

Perspective

Published on 2021-04-282022-10-04
Journal: Immunotherapy [Category] MERS, SARS, 신약개발,

[키워드] Abstract acute respiratory syndrome Anti-inflammatory cardiovascular disease characterized combination therapy coronavirus COVID-19 Cytokine storm diabete diabetes Dipeptidyl peptidase-4 DPP-4 inhibitors Drug repurposing dysregulated immune response Evidence homeostasis immunomodulation immunomodulator immunomodulators immunomodulatory properties immunomodulatory property increasingly inhibitor inhibitors modulate modulation pathophysiology patients with diabete Prevent prevent disease progression pro-inflammatory cytokine pro-inflammatory mediators progression Regulation reported SARS-CoV-2 severe coronavirus disease shown synergistic the cytokine storm Therapeutic approach Treatment Type type 2 diabetes VIDPP-4i virulence Vitamin D
[DOI] 10.2217/imt-2020-0349 PMC 바로가기 [Article Type] Perspective

No Efficacy of the Combination of Lopinavir/Ritonavir Plus Hydroxychloroquine Versus Standard of Care in Patients Hospitalized With COVID-19: A Non-Randomized Comparison

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] 95% CI Antiviral antiviral therapy antivirals approved baseline Combination confounders COVID-19 Cox regression model cumulative probability defined Drug repurposing Effectiveness female fractional inspired oxygen group groups HCQ hospitalized patient Hydroxychloroquine invasive invasive ventilation IQR Italy Lopinavir/ritonavir Nasopharyngeal swab no difference oxygen paO2/fiO2 Patient performed Pneumonia positive RT-PCR positive serology Probability randomized trial Retrospective analysis risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR secondary SOC specific treatment Standard Standard of care Swab swabs Trial viral shedding was used
[DOI] 10.3389/fphar.2021.621676 PMC 바로가기 [Article Type] Pharmacology

Drug Repurposing Approach, Potential Drugs, and Novel Drug Targets for COVID-19 Treatment

COVID-19 치료를 위한 약물 용도 변경 접근법, 잠재적 약물 및 새로운 약물 목표

Review

Published on 2021-04-222022-09-10
Journal: Journal of Environmental and Public Health [Category] SARS, 신약개발, 치료제,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies available data CD147 coronavirus Corticosteroids COVID-19 COVID-19 infection COVID-19 treatment COVID19 Cytokines dipeptidyl peptidase Dipeptidyl peptidase 4 drug Drug discovery Drug repurposing drug target effective enzyme eradication explicit Gene Expression identify include inhibitor inhibitors interferons Ivermectin management medication melatonin membrane fusion MERS-CoV molecular target novel Novel coronavirus nucleic acid other disease other diseases Potential protease inhibitors Protein repositioning repurposing RNA virus RNA-dependent RNA polymerase SARS-CoV structural protein Support target Teicoplanin therapeutic therapeutic agent therapeutic agents therapy treat treating COVID-19 Treatment Vaccines variety Viral virus viruses Wuhan Wuhan, China
[DOI] 10.1155/2021/6631721 PMC 바로가기 [Article Type] Review

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors

Research Article

Published on 2021-04-172022-10-29
Journal: Protein & Cell [Category] COVID-19, MERS, SARS,

Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action

약물 재목적화: 말라리아 치료를 위한 기존 및 새로운 항생제 검토: 항플라스모디움 작용의 빠른 발현을 가진 항생제 식별

Review

Published on 2021-04-152024-08-08
Journal: Molecules [Category] 말라리아,

[키워드] Antibiotics Drug repurposing malaria Plasmodium slow and fast-acting drugs
[DOI] 10.3390/molecules26082304 PMC 바로가기 [Article Type] Review

Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics

Article

Published on 2021-04-142022-10-28
Journal: Pharmaceutics [Category] COVID-19,