Persistence and Waning of Natural SARS-CoV-2 Antibodies Over 18 Months: Long-Term Durability of IgG Humoral Response in Healthcare Workers18개월 동안 천연 SARS-CoV-2 항체의 지속성 및 약화: 의료 종사자의 IgG 체액 반응의 장기간 지속성Article Published on 2022-08-012022-09-12 Journal: Journal of General Internal Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] IgG natural over response SARS-CoV-2 worker [DOI] 10.1007/s11606-022-07652-9 PMC 바로가기 [Article Type] Article
Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis류마티스 관절염 환자에서 SARS-CoV-2 백신 접종에서 BNT162b2 mRNA를 포함한 부스터의 역할Article Published on 2022-08-012022-09-12 Journal: Immunologic research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition age Analysis analyzed anti-IL6 antibody BAU BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster vaccination Booster vaccine Case report csDMARDs Disease activity Effect evaluated evidenced first vaccination Flow cytometry analysis HCW HCWs Health care worker IgG IgG level indicated jak inhibitors Level lymphocyte subpopulation mRNA BNT162b2 Necrosis Patient patients positive predictor RBD IgG Regression Rheumatoid rheumatoid arthritis role RTX SARS CoV-2 SARS-CoV-2 vaccination Seroconversion serum antibody spike therapy TNF treated Treatment vaccination Vaccination SARS-CoV-2 was determined [DOI] 10.1007/s12026-022-09283-y PMC 바로가기 [Article Type] Article
Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study심각한 동반이환이 있는 고령 인구의 혈청학적 COVID-19 백신 반응 및 내구성과 관련된 특성: 덴마크 전국 ENFORCE 연구Article Published on 2022-08-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] adjusted age antibody baseline ChAdOx1 Characteristics COVID-19 COVID-19 vaccination COVID-19 vaccine declined decrease defined enrolled first vaccination functional hyporesponsiveness identify IgG Immunity increasing age individual interquartile lack Level Male sex median age mRNA vaccine mRNA-1273 number of comorbidity older population outcomes parallel group participant Responder response risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serological Sex spike vaccination Vaccine vaccine dose vaccine response vaccine-induced antibodies vaccine-induced antibody waned were measured [DOI] 10.1016/j.cmi.2022.03.003 PMC 바로가기 [Article Type] Article
Serological findings following the second and third SARS-CoV-2 vaccines in lung transplant recipients폐 이식 환자에서 2차 및 3차 SARS-CoV-2 백신에 따른 혈청학적 소견Article Published on 2022-08-012022-09-12 Journal: Immunity, Inflammation and Disease [Category] SARS, 진단, [키워드] acute respiratory syndrome age antibody Antibody titer average BBIBP-CorV booster Booster vaccine ChAdOx1 Clinical data coronavirus coronavirus disease COVID COVID-19 died difference dose doses effective enrolled evaluated had no highest ICU IgG immunization Immunocompromised patients Immunoglobulin Immunological response induce Infection injection intensive care lung transplant median men Messenger RNA mRNA mRNA vaccine mRNA-1273 mRNA-based non-mRNA vaccine pandemic Patient patients positive recipient SARS-CoV-2 SARS-CoV-2 vaccine second dose serology Serum level significantly higher STABLE Support therapy third vaccination Transplant U/mL Vaccine was measured were given [DOI] 10.1002/iid3.646 PMC 바로가기 [Article Type] Article
Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody DeficiencyArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] anti-S IgG antibody association Autoimmunity B-cells baseline CD19 CD4 CD8 Cellular immune response clinical Cohort common common variable immune deficiency coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 mRNA vaccines criteria CVID deficiency develop Diagnosis disease dose expression Frequency HCs humoral IgA IgG IgG deficiency IgG subclasse immune Immune profile immunological characteristics impairment investigated memory Moderna Moderna mRNA vaccine mRNA mRNA vaccine naïve neutralization activity OX40 Patient Pfizer-BioNTech Pfizer-BioNTech mRNA vaccine Poor predicted primary antibody primary antibody deficiency response responses SARS-CoV-2 spike protein Selective IgG subclass deficiency significantly lower Specific Specific antibody deficiency. subset T-cell T-cell Response T-cells vaccination Vaccine vaccine response [DOI] 10.1007/s10875-022-01296-4 PMC 바로가기
Development of a smartphone-based quantum dot lateral flow immunoassay strip for ultrasensitive detection of anti-SARS-CoV-2 IgG and neutralizing antibodiesAnti-SARS-CoV-2 IgG 및 중화항체의 초고감도 검출을 위한 스마트폰 기반 양자점 측방유동 면역분석 스트립 개발Article Published on 2022-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 IgG Antigen Blood donors common cold COVID-19 cross-reaction development diagnosed healthy blood donors human serum IgG immunoassay Inactivated vaccine Inactivated Vaccines individual Influenza influenza B inoculated lateral flow immunoassay Neutralizing antibodies neutralizing antibody nucleic acid nucleic acid test pandemic Patient patients with influenza platform populations positive proportion protective effect quantum Quantum dot reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike protein Smartphone Spike protein subunit vaccines the SARS-CoV-2 the vaccine the vaccines two patients Vaccine virus-neutralizing antibody was used Whole blood [DOI] 10.1016/j.ijid.2022.04.042 PMC 바로가기 [Article Type] Article
Robust long-term immunity to SARS-CoV-2 in patients recovered from severe COVID-19 after interleukin-6 blockade인터루킨-6 차단 후 중증 COVID-19에서 회복된 환자에서 SARS-CoV-2에 대한 강력한 장기 면역Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료법, [키워드] 1:1 Affect anti-IL-6 anti-IL-6 therapy anti-IL6 antibody Antibody responses blockade conducted COVID-19 Critical deleterious effect deleterious effects domain Effect evaluated Follow-up greater humoral IgG IgG antibody IL-6 IL-6 blockade Immunity incidence increase in Infection interferon interferon-γ interleukin interleukin-6 Interleukin-6 blockade Laboratory longitudinal cohort study magnitude median Neutralizing antibodies neutralizing antibody no increase Patient patients hospitalized patients with COVID-19 positive proportion Prospective protective immunity receiving Reinfection responded to vaccination response responses risk robust SARS-CoV-2 SARS-COV-2 infection Seropositivity severe COVID-19 Spain subject subjects T-cell T-cell immunity T-cell Response T-cell responses therapy Tocilizumab treated [DOI] 10.1016/j.ebiom.2022.104153 PMC 바로가기 [Article Type] Article
Humoral immune response of BBIBP COVID-19 vaccination before and after the booster immunization추가 접종 전후 BBIBP COVID-19 백신의 체액성 면역 반응Multicenter Study Published on 2022-08-012022-09-12 Journal: Allergy [Category] MERS, SARS, 진단, [키워드] Administered antibody antibody persistence Antibody Response Antibody titer booster booster dose Coronavirus disease 2019 COVAX COVID-19 COVID-19 vaccination COVID-19 vaccine cVNT declined decrease disease dose elevated elicited healthy highlight IgA IgG immune response Immunity immunization inactivated Inactivated vaccine injection levels of antibody Month multicenter neutralization Neutralizing Neutralizing antibodies Neutralizing titer notable Participants peaked postvaccination pseudovirus recruited SARS-CoV-2 serum antibody shown Standard dose sVNT Vaccine virus neutralization test [DOI] 10.1111/all.15271 PMC 바로가기 [Article Type] Multicenter Study
Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
The kinetics and predictors of anti-SARS-CoV-2 antibodies up to 8 months after symptomatic COVID-19: A Czech cross-sectional studyCOVID-19 증상이 나타난 후 최대 8개월까지 항-SARS-CoV-2 항체의 동역학 및 예측인자: 체코 횡단 연구Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval acute phase analyzed anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody responses average Course COVID-19 Cox regression model cross-sectional demonstrated determinant determinants HCW HCWs healthcare worker IgG IgG and IgM IgM Immunoglobulin indicate knowledge Neutralizing number of symptom Odds ratio prediction predictor Receptor-binding domain reported responses S1 and S2 SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serology testing seropositive participant seropositive participants Seropositivity Seven specific antibodies Spike protein subsequent Symptom symptom duration symptom onset symptomatic tested the receptor-binding domain the spike protein time intervals was used [DOI] 10.1002/jmv.27784 PMC 바로가기 [Article Type] Article