A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responsesSARS-CoV-2 백신 BNT162b2의 단일 용량은 Fc 매개 항체 효과기 기능 및 T 세포 반응을 유발합니다Article Published on 2021-07-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Administered analyzed antibody antibody immunity binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 cellular condition contributing to coronavirus correlation COVID-19 dose doses effective Efficacy elicit elicited Fc-mediated effector function Fc-mediated effector functions function health authorities highlight humoral humoral responses include individual infected individuals mechanism mRNA mRNA vaccine neutralization Neutralizing activity public health authority raising regimen SARS-CoV-2 single dose spike glycoproteins Support T cell T cell response T cell responses T helper the SARS-CoV-2 vaccinate Vaccine vaccine efficacy variants while [DOI] 10.1016/j.chom.2021.06.001 PMC 바로가기 [Article Type] Article
Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 VariantsArticle Published on 2021-07-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activity antibodies approved B.1.1.7 B.1.351 B.1.617 B.1.617.2 circulating concern country COVID-19 decrease domain Efficacy Endemic epidemiological Genetic Genotype Lineage Local Mutation neutralization Neutralizing activity neutralizing effect no significant difference P.1 RBD RBD mutations reduction reported S477N SARS-CoV-2 sera Sputnik V statistically significant the RBD Transmissibility vaccination Vaccine Vaccines variant variants of concern virus virus neutralizing activity VoC [DOI] 10.3390/vaccines9070779 PMC 바로가기 [Article Type] Article
Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients입원 COVID-19 환자에서 B.1.1.7, B.1.351 및 p.1 SARS-COV-2 관심의 변형에 대한 혈청 중화 활동Communication Published on 2021-07-122022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] activity analyzed Antibody titer Antibody titers B.1.1.7 B.1.351 Brazil concern COVID-19 decrease elicited evaluated exposure to hospitalized patient hospitalized patients human serum immune protection Italy Mutation natural infection Neutralizing activity Neutralizing antibody titer new SARS-CoV-2 P.1 pandemic Protective reduction in SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants South Africa spike mutations Spike protein symptomatic infection the patient the spike protein United Kingdom vaccination variants variants of concern Viral viral variant Viral variants [DOI] 10.3390/v13071347 PMC 바로가기 [Article Type] Communication
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2Article Published on 2021-07-092022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 Analysis angiotensin-converting enzyme-2 antibodies antibody Antibody Response antigenic variation approach B.1.351 variant binding biologic COVID-19 disease COVID-19 patients Critical crystal Efficacy eight escape mutation feature Genetic highlight identify immunology in vitro in vivo Infection Intervention K417N Mutagenesis mutant Mutation NAb natural mutation Neutralizing activity neutralizing antibody overcome overlap Patient potent Protective Protein RBD receptor residue reveal SARS-CoV-2 SARS-COV-2 infection South Africa structural biology the Spike Vaccine virus [DOI] 10.1038/s41467-021-24514-w PMC 바로가기 [Article Type] Article
Identification of Human SARS-CoV-2 Monoclonal Antibodies from Convalescent Patients Using EBV ImmortalizationArticle Published on 2021-07-052022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] affected antibody sequence B cell clone clones COVID-19 infection Culture did not produce Donor EBV European functional Human identification in vitro Infection Isolation Italy lombardy mAb mAbs memory B cell monoclonal antibody Mutation Neutralizing activity pandemic positive purified recombinant proteins RNA SARS-CoV-2 SARS-CoV-2 isolates secreted sequenced Sequencing Spike protein supernatant tested the antibody the SARS-CoV-2 virus infection [DOI] 10.3390/antib10030026 PMC 바로가기 [Article Type] Article
Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasmaCOVID-19 회복기 혈장의 면역학적 특성에 대한 병원체 감소 방법의 영향Article Published on 2021-07-012022-09-12 Journal: Vox Sanguinis [Category] SARS, 진단, [키워드] Amotosalen collected comparison convalescent convalescent plasma COVID-19 COVID-19 convalescent donor COVID-19 convalescent plasma decrease dose greater Immunoglobulin immunological Impact initial likelihood material Methylene blue N-protein Neutralizing activity neutralizing antibody NtAbs pathogen Pathogen reduction plasma provide RBD reduced reduction remained Riboflavin riboflavin. SARS-CoV-2 SARS-CoV2 specific antibody statistically significant titre Treatment virus were measured [DOI] 10.1111/vox.13056 PMC 바로가기 [Article Type] Article
Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals이전에 감염된 개인의 COVID-19 백신 1회 투여에 대한 면역학적 기억 및 중화 활성Article Published on 2021-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Antibody Response B-cell baseline CD4 CD8+ CD8+ T-cell central memory chemiluminescence COVID-19 COVID-19 vaccine effector memory Efficacy elicited enrolled exposure group flow cytometry generate healthcare worker Immunological memory individual infected individual memory memory B-cell Memory B-cells memory T Memory T-cells mRNA vaccine naïve Neutralizing activity neutralizing antibody Neutralizing antibody response positive protective immunity SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection single dose Single-dose T-cell vaccination [DOI] 10.1016/j.ijid.2021.05.034 PMC 바로가기 [Article Type] Article
Preexisting vs. de novo antibodies against SARS-CoV-2 in individuals without or with virus infection: impact on antibody therapy, vaccine research and serological testingCommentary Published on 2021-07-012022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] antibody complicate cross-reactive antibodies de novo Epidemiology exhibited healthy individuals identify immune response Inclusion individual limitations Neutralizing activity nucleocapsid protein observation overcome pandemic positive potential limitation progressed PROTECT RBD receiving recent reported Research RT-PCR SARS-CoV-2 SARS-COV-2 infection sera serological test Serological testing Spike protein tested therapy Topic Treatment Vaccine virus while [DOI] 10.1186/s41231-021-00093-2 PMC 바로가기 [Article Type] Commentary
Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDsCommunication Published on 2021-06-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Ability ACE2 acute respiratory syndrome African anti-SARS-CoV-2 anti-spike antibody antibody Antibody neutralization binding activity characterized circulating variants coronavirus COVID-19 demonstrated diagnostic dominant E484K effective epitope epitope binning epitope bins escaped Flow humoral identifying implication induce Infection Lateral lateral flow immunoassay Lateral flow immunoassays Mutation N501Y neutralization neutralization activity Neutralizing activity neutralizing antibody not neutralize P.1 rapid neutralization test RBD RBDs Receptor binding domain receptor binding domain (RBD) retained SARS-CoV-2 SARS-CoV-2 variant Seven South Spike protein therapeutic therapeutic antibody cocktail variant variants [DOI] 10.3390/diagnostics11071190 PMC 바로가기 [Article Type] Communication
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infectionmRNA-1273 백신 접종에 의해 유도된 항체는 SARS-CoV-2 감염에서보다 수용체 결합 도메인에 더 광범위하게 결합합니다Research Article Published on 2021-06-302022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity affected antibodies antibody antibody epitope antibody epitopes antibody immunity Antibody Response Antibody responses antigenic evolution binding breadth characterized convalescent sera coronavirus deep demonstrated dose elicited epitope Epitopes erosion greater human antibody response Immunity immunization Infection less Moderna mRNA-1273 vaccine mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine Mutation natural infection neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody polyclonal antibodies polyclonal antibody raised RBD RBD mutation RBD-binding antibody Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein sera severe acute respiratory syndrome Coronavirus specificity Spike protein susceptibility the antibody response the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccine variant variants Viral viral evolution viral mutation Viral mutations [DOI] 10.1126/scitranslmed.abi9915 PMC 바로가기 [Article Type] Research Article