SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic ActivityArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 activity antibody antigenic distance AY.1 B.1.351 B.1.526 B.1.617 B.1.617 variants B.1.617.1 B.1.617.2 cleavage Complete contribute convalescent sera Delta delta variant display dominant effective enhanced exhibited greater India Infection Lineage mRNA mRNA-based vaccine neutralization neutralization resistance Neutralizing antibodies neutralizing antibody P.1 P681R property pseudovirus Pseudovirus neutralization assay pseudoviruses reduction reduction in resistance SARS-CoV-2 second wave sensitivity sera soluble ACE2 spike spike cleavage Spike protein Spread syncytia formation tested therapeutic variant variants [DOI] 10.3390/v13122485 PMC 바로가기 [Article Type] Article
Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sexResearch paper Published on 2021-12-102022-11-01 Journal: EBioMedicine [Category] COVID-19, SARS, [키워드] Advancing Affinity maturation Alliance antibody antibody affinity Award binding center contribute convalescent convalescent individual convalescent individuals countermeasure COVID-19 Department described determine dose FDA female females finding funding Human Impact individual Infection Infectious disease initiative knowledge Limited male manuscript maturation mRNA mRNA vaccination mutant mutants naïve neutralization titer neutralizing antibody NIAID NIH no difference number Participants Plasmon prefusion profile Pseudovirus neutralization assay RBD Receptor binding domain resonance SARS-CoV-2 Science sera service Sex sex differences significantly higher SPR supported surface the SARS-CoV-2 university Vaccine vaccine dose variants variants of concern variants of interest Virus neutralization VOCs VOIs was used [DOI] 10.1016/j.ebiom.2021.103748 PMC 바로가기 [Article Type] Research paper
A rapid real-time polymerase chain reaction-based live virus microneutralization assay for detection of neutralizing antibodies against SARS-CoV-2 in blood/serumResearch Article Published on 2021-12-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 24 hours antibody antiviral activity blood/serum calculate can be used conducted COVID-19 case cross-reactive Culture Cytopathic effect Dilution dilutions dose evaluate IgG titer individual individuals infected cell infective limiting dilution Live virus lysed microneutralization nasopharyngeal specimen neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing assay PCR percentage polymerase chain positive positively correlated RBD recovering from COVID-19 responses Result RNA RT-PCR SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 microneutralization assay SARS-CoV-2 strain sera serum serum antibody serum samples shown spike structural proteins TCID50 tested the Spike tissue Vero cells viral neutralization virus-neutralizing was used were used [DOI] 10.1371/journal.pone.0259551 PMC 바로가기 [Article Type] Research Article
A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern안정화된 단량체 수용체 결합 도메인은 우려되는 모든 SARS-CoV-2 변이체에 대해 고역가 중화 항체를 유도합니다Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] (Beta Against antibody B.1 B.1.351 B.1.351 RBD B.1.617.2 breadth cocktail components concern COVID-19 elicited expressed generate hamster hamster immunization hamsters High-dose Host hyperstable mutants immunized immunogen immunogenic increase in introduced lack lyophilization mammalian cell mammalian cells melting temperature mice microbial Mutagenesis mutant Mutation neutralization titer neutralization titers neutralized Neutralizing antibodies Pichia pastoris produced Protein RBD room temperature SARS-CoV-2 SARS-CoV-2 spike receptor-binding domain saturation sera significantly spike receptor-binding domain squalene stabilizing mutation SWE temperature the SARS-CoV-2 thermotolerance vaccination Vaccine variants of concern Viral viral challenge VoC was used water wild-type [DOI] 10.3389/fimmu.2021.765211 PMC 바로가기 [Article Type] Immunology
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together밤라니비맙 단독 또는 밤라니비맙과 에테세비맙을 함께 투여받은 경증 또는 중등도 COVID-19 환자에서 SARS-CoV-2에 대한 내인성 항체 반응Clinical Trial Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, 치료법, 치료제, [키워드] Administered antibodies Antibody Response Antibody titer Antibody titers antigenic B.1.351 bamlanivimab baseline Beta Beta variant binding breadth clinically Cohort collected correlated COVID-19 Day decrease develop domain Effect endogenous epitope Epitopes etesevimab evade Factor full-length Hospitalization humoral immune response in viral investigated longitudinal mAb mAbs Mild Moderate COVID-19 monoclonal antibody monotherapy Mortality multiplex mutant N-terminal domain Neutralization assay Neutralizing activity neutralizing monoclonal antibodies nucleocapsid protein Patient performed Placebo Received receiving recipient reduced reductions in response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 pseudovirus sera serology serum sample specificity subsequent titer titers treated Treatment Trial variant Viral Viral load [DOI] 10.3389/fimmu.2021.790469 PMC 바로가기 [Article Type] Clinical Trial
The potential of COVID-19 patients’ sera to cause antibody-dependent enhancement of infection and IL-6 productionCOVID-19 환자의 혈청의 잠재력은 감염 및 IL-6 생산의 항체 의존적 향상을 유발합니다.Article Published on 2021-12-092022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADE Antibody-dependent enhancement cell line clone cloned coronavirus COVID-19 demonstrated dengue virus evaluate host cell host cells IL-6 immortalized Infection infection with SARS-CoV-2 infections initiated myeloid cell neutralizing antibody other coronavirus other coronaviruses productivity respiratory resulting SARS-CoV-2 SARS-COV-2 infection screened sera severe acute respiratory syndrome Coronavirus severe COVID-19 patient severe COVID-19 patients stimulate susceptibility TMPRSS2 vaccination Vaccine development vaccine trial virus infections [DOI] 10.1038/s41598-021-03273-0 PMC 바로가기 [Article Type] Article
Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients사르데냐 다발성 경화증 환자에서 BNT162b2 백신에 대한 체액 반응에 대한 다양한 질병 수정 요법의 효과Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] Acetate addition affected age Alemtuzumab analyzed anti-SARS-CoV-2 vaccine Antibody titer Antibody titers BNT162b2 BNT162b2 vaccine Clinical data clinically COVID-19 COVID-19 vaccine demographic difference dimethyl fumarate Disease-modifying therapy drug Effect Factor fingolimod followed by fumarate Glatiramer healthy control humoral immune response Humoral immunity Humoral response immune response infected with SARS-CoV-2 interferon investigated linear Male sex mixed-effects model mRNA mRNA-based Multiple multiple sclerosis objective observé of BNT162b2 Older age Patient patients patients treated Prevent response Result Sardinian SARS-CoV-2 SARS-COV-2 infection sclerosis second dose sera serology Sex significantly significantly higher significantly lower smoking smoking status statistically significant difference Teriflunomide tested therapy Treatment treatment group treatment groups uninfected untreated patients vaccination Vaccine vaccine efficacy were assessed [DOI] 10.3389/fimmu.2021.781843 PMC 바로가기 [Article Type] Immunology
Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021Comirnaty(BNT162b2 mRNA) 백신 유도 혈청에 의한 돌연변이 E484K가 있는 SARS-CoV-2 Delta 변이 하위 계통 AY.4.2 및 B.1.617.2의 중화, 덴마크, 2021년 11월 1일~26일Rapid Communication Published on 2021-12-092022-09-10 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] AY.4.2 B.1.617.2 BNT162b2 BNT162b2 mRNA circulating comparable coronavirus COVID-19 Delta delta variant Denmark E484K E484K mutation evaluated Factor less Lineage lineages Mutation neutralisation Poland prevalent recipient reduction in Romania SARS-CoV-2 sensitivity sera Spread strain Strains Surveillance the SARS-CoV-2 United Kingdom Vaccine variant Virus neutralization [DOI] 10.2807/1560-7917.ES.2021.26.49.2101059 PMC 바로가기 [Article Type] Rapid Communication
A Highly Conserved Peptide Vaccine Candidate Activates Both Humoral and Cellular Immunity Against SARS-CoV-2 Variant Strains고도로 보존된 펩타이드 백신 후보는 SARS-CoV-2 변종 균주에 대한 체액 및 세포 면역 모두를 활성화합니다Immunology Published on 2021-12-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activated activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against amino acids antibody antigenic peptide B cell B cells B-cell epitopes B.1.617.2 BALB/c mice binding candidate CD8 Cellular immune response cellular immunity circulating conserved convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protection dominant Efficacy Epitopes functional generate humoral humoral immune response immunization immunized Immunological memory induce key amino acid key amino acids L452R mechanism mice mutants Neutralizing peptide Point mutation Protective provide RBD-specific antibody RBD9.1 Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sera severe acute respiratory syndrome Coronavirus specific antibodies strain Strains sustained T cell T cells T-cell T-cell Response the receptor-binding domain unique Vaccine vaccine candidate vaccine candidates [DOI] 10.3389/fimmu.2021.789905 PMC 바로가기 [Article Type] Immunology
Autoimmune Encephalitis After SARS-CoV-2 Infection: Case Frequency, Findings, and OutcomesSARS-CoV-2 감염 후 자가면역 뇌염: 사례 빈도, 소견 및 결과Article Published on 2021-12-072022-09-12 Journal: Neurology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome age application arising assist Ataxia Autoimmune Autoimmune encephalitis case sery cause chemiluminescence clinical presentation clinical record Cohort cohort patient coronavirus coronavirus disease COVID-19 COVID-19 illness COVID-19 pandemic CSF delirium Department determine diagnosed diagnoses diagnostic Diagnostic Criteria died drug Encephalitis Encephalopathy feature food Frequency IgG immune Immunoglobulin Infection Laboratory Mayo Clinic median symptom memory MRI neurologic NEUROLOGY Non-COVID-19 one patient overlapped PASC Patient Pneumonia positive Postinfectious problems reported representing Research residual SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antibody Seizure sera spike glycoprotein tested the SARS-CoV-2 therapy total antibody viral particle women [DOI] 10.1212/WNL.0000000000012931 PMC 바로가기 [Article Type] Article