First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsSARS-CoV-2 및 변이체에 대한 강력한 예방 및 치료 효능을 지닌 동급 최초의 삼중특이성 VHH-Fc 기반 항체Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] ACE-2 addition antibody Antibody therapy cellular characterized comparable COVID-19 cases COVID-19 pandemic COVID-19 vaccination death Delta demonstrated distribution Drug development Efficacy Efficacy and safety epitope evaluated feature greatly reduce hospitalizations humanized Immunity in vitro in vivo intranasal lead Measures multiple epitope omicron parameter PBS prevented Prophylactic Prophylaxis provided reduced reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants shown tested the vaccine the vaccines therapeutic efficacy Treatment treatment for COVID-19 variant Viral Viral load viral loads while [DOI] 10.1038/s41598-022-07952-4 PMC 바로가기 [Article Type] Article
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection증상이 있는 SARS-CoV-2 알파 감염이 있는 백신 접종 환자의 적응 면역 반응Article Published on 2022-03-082022-09-11 Journal: JCI Insight [Category] MERS, SARS, 변종, 진단, [키워드] Adaptive immunity Alpha Alpha variant antibody antibody levels Antibody titers Breakthrough infection breakthrough infections caused Cellular immune response cellular immune responses characterized Cohort COVID-19 declined defined disease ELISA Genetic variation HCs healthy control IFN-γ IgG antibody IgG antibody titers IgG titer IgG titers immune immune response immune responses infected patient infected patients Infection Infectious disease mRNA vaccination neutralization activity Neutralizing neutralizing antibody Patient protective immunity response SARS-CoV-2 SARS-CoV-2 vaccination severe disease sustained symptomatic symptomatic infection symptomatic infections symptomatic patient Symptomatic patients T cell T cell response T cell responses the SARS-CoV-2 the vaccine vaccination Viral viral variant Viral variants virus Virus neutralization virus-specific T cell [DOI] 10.1172/jci.insight.155944 PMC 바로가기 [Article Type] Article
Social-Cyber Maneuvers During the COVID-19 Vaccine Initial Rollout: Content Analysis of TweetsOriginal Paper Published on 2022-03-072022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] Analysis Analyzer anti-vaccine API approval belief BEND maneuvers build characterized collected Combination communication Community competing conducted content coronavirus COVID-19 COVID-19 vaccine Cybersecurity death disinformation domain effective Effectiveness explain facilitate group groups health information initial initial distribution maneuver manipulation media Metrics neutralize objective ORA-PRO organization Pfizer-BioNTech platform positive previous study pro-vaccine programming reducing response to vaccination Result security Side effect social cybersecurity social media social network analysis social-cyber maneuvers spread of COVID-19 the vaccine Twitter vaccinate vaccination Vaccine [DOI] 10.2196/34040 PMC 바로가기 [Article Type] Original Paper
COVID-19 vaccine perceptions in the initial phases of US vaccine roll-out: an observational study on redditObservational Study Published on 2022-03-072022-10-04 Journal: BMC Public Health [Category] MERS, SARS, 임상, [키워드] Accuracy association changes in collected Community computational conducted contribute COVID-19 COVID-19 vaccination COVID-19 vaccine determine early phase Efficacy effort IMPROVE individual information initial Intervention media misinformation Pfizer press Prevalence Reddit reduced Research Result social network analysis the vaccine Topic vaccination Vaccine vaccine trial Vaccines [DOI] 10.1186/s12889-022-12824-7 PMC 바로가기 [Article Type] Observational Study
Manifesto of the pediatricians of Emilia-Romagna region, Italy, in favor of vaccination against COVID in children 5–11 years oldDebate Published on 2022-03-052022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, MERS, SARS, [키워드] activity Adults age Caccine hesitancy caused children conscious contribute COVID COVID-19 COVID-19 vaccines Cultural developmental disease effective Emilia-Romagna family favor Federation form growth Health hospital information Italian Italy Manifesto mental health neonatology Paediatric infectious diseases pandemic parent parents pathology Pediatrician pediatrics PROTECT Region regulatory authority Safe SARS-CoV-2 SARS-COV-2 infection School Side effects Society Spread Stress the vaccine union Vaccinating vaccination Vaccine virus [DOI] 10.1186/s13052-022-01229-2 PMC 바로가기 [Article Type] Debate
Comparison of Moderna versus Pfizer-BioNTech COVID-19 vaccine outcomes: A target trial emulation study in the U.S. Veterans Affairs healthcare systemResearch article Published on 2022-03-052022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adjusted hazard ratio Affair age all age groups analyzed BNT162b2 category clinical trials Comorbidity COVID-19 vaccination COVID-19 vaccine death delta variant Department Electronic health records finding follow-up period follow-up time funding greater Healthcare system Hospitalization Infection less Medicare Moderna mRNA COVID-19 vaccine mRNA-1273 National occurred outcome Pfizer-BioNTech predominant propensity score matching rates of infection recipient recipients risk risk of infection SARS-COV-2 infection SARS-CoV-2 infections shown significantly lower statistically significant the vaccine Trial vaccination Vaccine vaccine dose vaccine group veteran [DOI] 10.1016/j.eclinm.2022.101326 [Article Type] Research article
Correlates of COVID-19 vaccine hesitancy in Austria: trust and the governmentOriginal Article Published on 2022-03-052022-10-30 Journal: Journal of public health (Oxford, England) [Category] COVID-19, MERS, SARS, [키워드] 95%CI Austrians Behaviour communicable diseases complex confidence coronavirus disease correlated correlation COVID-19 COVID-19 vaccine demographics dimension expected Factor Government independent Mutation pandemic Result Safe the vaccine Vaccine Vaccine hesitancy Vaccines [DOI] 10.1093/pubmed/fdab122 PMC 바로가기 [Article Type] Original Article
A stochastic process based modular tool-box for simulating COVID-19 infection spreadResearch article Published on 2022-03-052022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료기술, [키워드] absence affected applied average basic reproduction number can be used comparable coronavirus country COVID-19 COVID-19 infection COVID-19 simulation defined develop disease disease modeling Effect Efficacy Epidemics Factor fraction function geographical area growth infected individuals Infection Infectious disease initial intrinsic Mask maximum-likelihood novel coronavirus disease pandemic parameter performed producing quarantine R language Research Result Spread stages the epidemic the vaccine vaccination Viral virulence [DOI] 10.1016/j.imu.2022.100899 [Article Type] Research article
Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients면역 저하 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 반응을 평가하는 초기 임상 시험의 통찰력Review Published on 2022-03-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] adaptive administration agonist animal model Anti-CD19 anti-CD20 anti-CD38 Assessing BNT162b2 CD4 clinical clinical trial component COVID-19 Critical CTLA4 deficiency dose effective Genetic healthy humans immune systems Immunocompromised Immunocompromised patient immunodeficiency Immunosuppressed Immunosuppressive medication inborn errors of immunity increased risk insight jak inhibitors knowledge mRNA mRNA vaccination mRNA vaccine mRNA-1273 mRNA1273 Patient predictor PROTECT response SARS-CoV-2 SARS-CoV-2 vaccination severe disease T-cell the vaccine therapeutic Therapies transplantation Treatment Trial tyrosine vaccination Vaccine [DOI] 10.3389/fimmu.2022.827242 PMC 바로가기 [Article Type] Review
Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine CenterArticle Published on 2022-03-042022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Adverse AEFI AZD1222 BNT162b2 BNT162b2 vaccine center clinical trials COVID-19 COVID-19 vaccine COVID-19 vaccines drug drugs effective effort Fever first dose immunization incidence injection Italian Italy men Pain persist questionnaire report safety profile Surveillance the vaccine university vaccination Vaccine women [DOI] 10.3390/jcm11051408 PMC 바로가기 [Article Type] Article