Liver Injury in Patients Hospitalized for COVID-19: Possible Role of TherapyReview Published on 2022-01-262022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE-2 Acute liver injury bind chronic liver disease COVID-19 Cytokine storm Cytopathic effect determine drug drugs Factor forms Immune-mediated Injury Last liver Liver damage Liver injury mechanisms NIV non-invasive ventilation organ damage Prevalence receptors role SARS-CoV2 SARS-CoV2 infection treat Treatment virus with COVID-19 [DOI] 10.3390/vaccines10020192 PMC 바로가기 [Article Type] Review
COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled AnalysisArticle Published on 2022-01-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Analysis anticoagulation assumption Clinical characteristics Cohort collected Complication complications contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical Critically ill database diagnosed with COVID-19 ECMO hemorrhage Hemorrhagic Hemostasis heterogeneous ICH Impact Intracranial intracranial hemorrhage item literature review median age Mortality Pathomechanism pathophysiological Patient patients performed poor prognosis Prevalence Prognosis radiological Reporting review SARS-CoV2 selection process Series subtype Subtypes Support systematic review the patient thromboembolic [DOI] 10.3390/jcm11030605 PMC 바로가기 [Article Type] Article
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
Clinical, anamnestic, and sociodemographic predictors of positive SARS-CoV-2 testing in children: A cross sectional study in a tertiary hospital in Italy소아에서 양성 SARS-CoV-2 검사의 임상적, 기억상실증 및 사회인구학적 예측인자: 이탈리아의 한 3차 병원의 단면 연구Research Article Published on 2022-01-252022-09-12 Journal: PLoS ONE [Category] 진단, [키워드] 95% CI adopted age Ageusia analysed Analysis association calculation Care child health children chill chills clinical clinical symptom Clinical symptoms coefficient collected Contact contact with COVID-19 cross Data collection determine diarrhoea dissemination earache female Fever headache Health hospital identify information IRCCS Italy Multivariate analysis Negative predictive value negative test objective Outpatient outpatient clinic parents Perspective positive positive swab Predictive Predictive value predictor public health reduce Research Result retained risk SARS-CoV-2 swab SARS-CoV-2 testing SARS-CoV2 School sensitivity setting Sex Sociodemographic Sociodemographic characteristics sore throat symptomatic case Symptoms tested the disease variable [DOI] 10.1371/journal.pone.0262923 PMC 바로가기 [Article Type] Research Article
ABO blood grouping and COVID-19: a hospital-based study in Eastern IndiaResearch Published on 2022-01-202022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 95% CI ABO ABO blood grouping ABO blood type ACE acute respiratory syndrome addition age analyzed antibody association Blood Blood Group Cell control group controls coronavirus coronavirus disease COVID COVID 19 COVID-19 Critical care disease disease severity enzyme experimental model groups Hepatitis higher risk highest Host ICU admission in viral India Infection inhibit Interaction involved Microsoft Excel outbreak Pathogenesis Patient polymerase chain positive positive patient Prevalence Previous studies qRT-PCR Quantitative Real-time PCR receptor recorded Result Retrospective study risk factor SARS-CoV2 severity shown statistical susceptibility viral disease Viral load virus [DOI] 10.1186/s43042-022-00225-9 PMC 바로가기 [Article Type] Research
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry PerspectiveCOVID-19의 잠재적 치료에 대한 접근: 의약 화학 관점의 일반 개요Review Published on 2022-01-202022-09-10 Journal: Molecules [Category] SARS, 변종, 치료제, [키워드] 3CLpro inhibitors active against affected Anti-inflammatory antibody Antiviral arising Cell characteristic charge Chemistry corticoids Corticosteroids COVID-19 pandemic cytokine Cytokine storm drug drugs targeting elongation factor Genome host cell host protein host proteins hyperinflammatory phase IL6 antibodies Inflammatory interleukin interleukin 6 involved Jak JAK-STAT inhibitors kinases less Mutation pharmacological treatment pharmacological treatments polyprotein Potential protease Protein RdRp inhibitors S antibodies SARS-CoV-2 SARS-CoV2 serine protease inhibitors sphingosine SphK2 inhibitors stages target the cell the disease therapeutic intervention triggered vaccination variants Viral viral entry viral genome viral infection Viral proteins virus [DOI] 10.3390/molecules27030658 PMC 바로가기 [Article Type] Review
A Multicenter Retrospective Analysis on the Etiology of Bradycardia in COVID-19 PatientsCardiology Published on 2022-01-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Analysis analyzed appear association Beta-blocker bradycardia bradycardic cause COVID-19 COVID-19 patient COVID-19 patients COVID-19 positive patient defined EMR etiology excluded hospital Hospital stay Hospitalization IBM increased mortality mechanism Mortality multicenter outcomes Patient Protective Remdesivir reported Result retrieved Retrospective analysis SARS-CoV2 severe bradycardia significantly SPSS SQL steroid sustained the patient ventilator was used [DOI] 10.7759/cureus.21294 PMC 바로가기 [Article Type] Cardiology
Sequelae and Comorbidities of COVID-19 Manifestations on the Cardiac and the Vascular SystemsPhysiology Published on 2022-01-142022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome age aging angiotensin-converting enzyme 2 cardiac Cardiac arrhythmia cardiac arrhythmias cardiac complication Cardiac complications cardiovascular comorbidities cardiovascular condition cardiovascular disease case fatality rates complications complications of COVID-19 condition conditions coronavirus cough COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical case damaged de novo diabetes dysregulation elderly endothelial cells evaluate expressed expression Fever Glia greater highest Hypercoagulation hypertension improve clinical outcome in-depth analysis incidence include increased risk Infection Interaction ischemic heart disease manifestation mechanism mortality risk Myocardial Myocardial infarction Neuron Neuropathy oxygen supply pandemic Patient patients presenting symptom Prognosis prognostic indicator reduce reported risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV2 Shortness of breath shown System systemic hyper-inflammation the SARS-CoV-2 tissue vasculature virus [DOI] 10.3389/fphys.2021.748972 PMC 바로가기 [Article Type] Physiology
Safety of the BNT162b2 mRNA COVID-19 vaccine in oncologic patients undergoing numerous cancer treatment options A retrospective single-center study5700 Published on 2022-01-142022-10-30 Journal: Medicine [Category] COVID-19, [키워드] active cancer Administered biologic BNT162b2 mRNA Cancer cancer patient cancer treatment caused Chemotherapy COVID-19 COVID-19 pandemic COVID-19 vaccine diagnose Diagnosis died dose FIVE Hospitalization Hospitalized identify Immune checkpoint inhibitors Immunotherapy incidence Local Mild moderate outcomes participant Patient Prevalence protocol Radiation released reported retrospective Safe Safety SARS-CoV2 severe disease Side effect single center single-center study systemic side effect the vaccine therapy Treatment Type undergo Vaccine vaccine safety virus [DOI] 10.1097/MD.0000000000028561 PMC 바로가기 [Article Type] 5700
Vaccine-associated complications: a comparative multicenter evaluation among dental practitioners and dental students—which candidate vaccine is more safe in SARS COV II, Gam-COVID-Vac (Sputnik V), ChAdOx1 nCoV-19 (AstraZeneca), BBV152 (Covaxin), or BBIBP-CorV(Sinopharm)?Research Published on 2022-01-132022-10-30 Journal: Maxillofacial Plastic and Reconstructive Surgery [Category] COVID-19, [키워드] acute respiratory syndrome adverse effects adverse event age analyses AstraZeneca BBIBP-CorV candidate vaccine ChAdOx1 nCoV-19 clinical assessment conducted coronavirus dental practitioner EBV evaluate fatigue Frequency Gam-COVID-Vac individual Infection Influenza injection local pain majority malaise MERS multicenter Pain platform provoking questionnaire reaction reported Result retained risk Safe sample sizes SARS-CoV2 SARSCoV-2 Side effect Side effects Side-effect similar studies Sinopharm supplementary material Symptom systemic side effects vaccination Vaccine vaccine administration [DOI] 10.1186/s40902-021-00330-6 PMC 바로가기 [Article Type] Research