Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old PigsArticle Published on 2017-05-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] alignment amino acid substitution antibody cell culture-adapted virus Conventional conventional pig detectable diarrhea elicited epidemic diarrhea fecal Frame full-length host antibody response IgA IgG Immunoglobulin immunoglobulin A induced insertion live-attenuated vaccine membrane protein neutralizing antibody nucleotide change ORF3 pathogenicity PEDV pig Porcine epidemic diarrhea virus post inoculation Protein reduction in response sequence strain subsequent Taiwan viral shedding virus [DOI] 10.3390/v9050121 PMC 바로가기 [Article Type] Article
Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S , which Encode Subcomponents C1r and C1s of Complement치주 엘러스-단로스 증후군은 보체의 하위 구성요소 C1r 및 C1을 인코딩하는 C1R 및 C1S의 돌연변이로 인해 발생합니다.Article Published on 2016-11-032022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] affected attached gingiva autosomal-dominant disorder bruising C1q C1r candidate gene causes characterized childhood classical clinical Clinical features Complement pathway connection connective tissue defined early-onset periodontitis Ehlers-Danlos syndrome Endoplasmic reticulum feature Frame Genetic Gingiva heterotetramer heterozygous homeostasis hyperpigmentation identify include independent individual Inflammatory insertion/deletion International joint joint hypermobility lack locus loss of teeth mapped Mild Missense Musculoskeletal Mutation open periodontal Periodontitis physiological Premature pretibial hyperpigmentation Protein recruited skin subunit subunit interface subunits Symptoms teeth variant Vascular vascular fragility [DOI] 10.1016/j.ajhg.2016.08.019 PMC 바로가기 [Article Type] Article
High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome ProfilingResearch Article Published on 2016-02-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed [DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article
Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID miceOriginal Article Published on 2015-09-082022-10-28 Journal: Archives of Virology [Category] Coronavirus, MERS, [키워드] absence association clone combined immunodeficiency comparison coronavirus determinant Driver cDNA Frame genome sequence genomic sequence Hepatitis identify Langerhans cell histiocytosis liver mice murine murine hepatitis virus new strain new virus nucleotide sequence PCR predicted Protein protein level retroviral retrovirus SCID Mouse sequence sequenced Subtract cDNA Library suppression Suppression Subtractive Hybridization Tester cDNA tissues unique virulent virus virus strain was used whole genome [DOI] 10.1007/s00705-015-2592-y PMC 바로가기 [Article Type] Original Article
Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)Research Article Published on 2015-04-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] accelerated acute respiratory illness amplicons amplification Amplification assay amplify applied assays asymmetric cause coronavirus cross-react detect detection diagnostics E gene facilitate Frame genomic infected cell culture Infection infections isothermal amplification loci management MERS-CoV Middle East mortality rate ORF1b gene plaque forming unit point-of-care primer probe reported respiratory Respiratory pathogens respiratory syndrome coronavirus resulting reverse transcription RT-LAMP supernatant upstream [DOI] 10.1371/journal.pone.0123126 PMC 바로가기 [Article Type] Research Article
Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ( IFNL4 )개선된 바이러스 제거와 관련된 변이체에 대한 선택은 인터페론 람다 4(IFNL4)의 국소적 적응형 가성화를 유도합니다.Research Article Published on 2014-10-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABC adaptive allele America Antiviral antiviral activity approach Approximate Asia Asian association Bayesian clearance complex conserved disease drive driving East Elimination ENCODE environmental force Europe European Evidence evidence of fixation Frame Frequency functional Genetic genetic association Genetic variant Genetic variation groups HCV hepatitis C hepatitis C virus heterogeneity Human human populations IFN-λ IFNL4 Improved inactivation Infection insertion Interferon lambda Lambda mammal mammals Migration moderate Mutation Open reading frame phenotype phenotypic diversity Population populations positive Positive selection Protein provide pseudogene raise raising reached resulting Selection selective SNP SNPs strength susceptibility the strongest turn variant virus [DOI] 10.1371/journal.pgen.1004681 PMC 바로가기 [Article Type] Research Article
Performance and clinical validation of the RealStar ® MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA중동 호흡기 증후군 코로나바이러스 RNA 검출을 위한 RealStar ® MERS-CoV 키트의 성능 및 임상 검증Article Published on 2014-03-282022-09-25 Journal: Journal of Clinical Virology [Category] MERS, 진단, [키워드] Altona Diagnostics amplification analytical sensitivity assays clinical sample comparable coronavirus cross-reactivity Diagnosis diagnostic assay Diagnostic method envelope Epidemiology Frame genomic region Germany Hamburg highly pathogenic IMPROVE Internal control management MERS-CoV MERS-CoV infection MERS-CoV RNA Middle East Middle East respiratory syndrome molecular Munich nucleic acid objective ORF Patient PCR performance real-time RT-PCR Respiratory disease respiratory diseases respiratory pathogen respiratory sample respiratory syndrome coronavirus Result RNA RT-PCR assay RT-PCR kit target region upstream virus WHO World Health Organization [DOI] 10.1016/j.jcv.2014.03.012 PMC 바로가기 [Article Type] Article
Genetic Variability and Phylogeny of Current Chinese Porcine Epidemic Diarrhea Virus Strains Based on Spike , ORF3 , and Membrane GenesResearch Article Published on 2014-01-222022-10-29 Journal: The Scientific World Journal [Category] Coronavirus, MERS, [키워드] amplified Analysis analyzed antigenicity changed Characteristics China Chinese conserved current death demonstrated different epidemic diarrhea Frame Gene Genes homology hydrophobicity Immunity isolate M gene membrane Mutation ORF ORF3 outbreak PEDV S gene sequence sequenced spike Spread strain subgroup suggested the disease the S protein the vaccine variant Variation virulence virulent virus widespread [DOI] 10.1155/2014/208439 PMC 바로가기 [Article Type] Research Article
A Leaderless Genome Identified during Persistent Bovine Coronavirus Infection Is Associated with Attenuation of Gene ExpressionResearch Article Published on 2013-12-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Analysis attenuation Bovine coronavirus Cell culture contribute determined different downstream Efficiency example expression found Frame Genome genomes genomic genomic RNA Identified Infected Infection mutant viruses ORF persistence persistent Postinfection replicative retained RNA selected sequence sgmRNA subgenomic mRNA Transcription translation viral infection was impaired [DOI] 10.1371/journal.pone.0082176 PMC 바로가기 [Article Type] Research Article
Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229EArticle Published on 2012-12-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 229E acute respiratory disease alpaca anthroponosis appear characterization coronavirus demonstrated FIVE Frame Genome genomic sequencing HCoV-229E Human human coronavirus humans identification identity isolate molecular evolution MOST novel Novel coronavirus Nucleocapsid gene nucleotide occurred respiratory reverse zoonosis spike gene sequence UTR virus virus transmission zoonosis [DOI] 10.3390/v4123689 PMC 바로가기 [Article Type] Article