Humoral immune response of BBIBP COVID-19 vaccination before and after the booster immunization추가 접종 전후 BBIBP COVID-19 백신의 체액성 면역 반응Multicenter Study Published on 2022-08-012022-09-12 Journal: Allergy [Category] MERS, SARS, 진단, [키워드] Administered antibody antibody persistence Antibody Response Antibody titer booster booster dose Coronavirus disease 2019 COVAX COVID-19 COVID-19 vaccination COVID-19 vaccine cVNT declined decrease disease dose elevated elicited healthy highlight IgA IgG immune response Immunity immunization inactivated Inactivated vaccine injection levels of antibody Month multicenter neutralization Neutralizing Neutralizing antibodies Neutralizing titer notable Participants peaked postvaccination pseudovirus recruited SARS-CoV-2 serum antibody shown Standard dose sVNT Vaccine virus neutralization test [DOI] 10.1111/all.15271 PMC 바로가기 [Article Type] Multicenter Study
Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
The kinetics and predictors of anti-SARS-CoV-2 antibodies up to 8 months after symptomatic COVID-19: A Czech cross-sectional studyCOVID-19 증상이 나타난 후 최대 8개월까지 항-SARS-CoV-2 항체의 동역학 및 예측인자: 체코 횡단 연구Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval acute phase analyzed anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody responses average Course COVID-19 Cox regression model cross-sectional demonstrated determinant determinants HCW HCWs healthcare worker IgG IgG and IgM IgM Immunoglobulin indicate knowledge Neutralizing number of symptom Odds ratio prediction predictor Receptor-binding domain reported responses S1 and S2 SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody serology testing seropositive participant seropositive participants Seropositivity Seven specific antibodies Spike protein subsequent Symptom symptom duration symptom onset symptomatic tested the receptor-binding domain the spike protein time intervals was used [DOI] 10.1002/jmv.27784 PMC 바로가기 [Article Type] Article
Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review코로나19 예방접종으로 촉발된 HCV 치료 이력이 있는 자가면역 간염: 증례 보고 및 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Clinical journal of gastroenterology [Category] 치료제, [키워드] administration antibody Autoimmune diseases Autoimmune hepatitis Blood Case report Cell coronavirus disease COVID-19 COVID-19 vaccination described diagnosed direct-acting antiviral Direct-acting antivirals effective elevated HCV HCV antibody Hepatitis hepatitis C hepatitis C virus hospital IgG infiltration interface literature review Liver injury plasma Plasma cell positive real-time RT-PCR referred to RNA SARS-CoV-2 steroid Treatment triggered vaccination Vaccine worldwide pandemic [DOI] 10.1007/s12328-022-01654-0 PMC 바로가기 [Article Type] Review
Kinetics of SARS-CoV-2 antibody responses pre-COVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case-control study중증 호흡부전 환자에서 코로나19 이전 및 코로나19 이후 회복기 혈장 수혈에 대한 SARS-CoV-2 항체 반응의 동역학: 관찰 사례-대조군 연구Observational Study Published on 2022-08-012022-09-12 Journal: Journal of Clinical Pathology [Category] MERS, SARS, 임상, 진단, [키워드] anti-RBD anti-RBD IgM antibodies antibody Antibody titre binding domain Blood blood draw Blood Transfusion case-control study CCP Clinical outcome clinical outcomes control patient controls convalescent plasma COVID-19 ECMO ELISA extracorporeal membrane oxygenation hospital ICU IgG IgG and IgM IMPROVE increase indicated individual intensive care Kinetics LOS median pandemic Patient patients patients with COVID-19 plasma Primary outcome RBD recipient SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV2 secondary outcome seronegative seropositive severe respiratory failure Support survival the SARS-CoV-2 titre Treatment vaccination ventilator ventilatory were measured while with COVID-19 [DOI] 10.1136/jclinpath-2020-207356 PMC 바로가기 [Article Type] Observational Study
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy임신 및 영아기 mRNA 백신 제품 및 기능성 항체의 태반을 통한 전달 평가Article Published on 2022-07-302022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody antibodies antibody binding Blood Cohort Critical Effectiveness epitope evaluate Evidence functional IgG immunoprecipitation individual infancy mRNA mRNA vaccine neutralizing antibody Newborn persist Placenta placental Pregnancy Protective antibody Protein provided SARS-CoV-2 SARS-CoV-2 vaccination Sequencing spike tissue transfer transferred vaccination [DOI] 10.1038/s41467-022-32188-1 PMC 바로가기 [Article Type] Article
Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccineBNT162b2 mRNA 백신 2회 접종 후 6개월 동안 일본 의료 종사자의 항체 역가 및 세포 면역의 역학Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] All participant All participants Analysis antibody Antibody titer Antibody titers Asymptomatic BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Breakthrough infection breakthrough infections Cellular immune response cellular immune responses cellular immunity clinical trial collected conducted COVID-19 determinant determinants determine dose Dynamics elevated follow-up period healthcare healthcare worker Healthcare workers humoral IgG immune response immune responses incidence Japanese knowledge medical condition Medical conditions mRNA vaccine mRNA vaccines Nucleocapsid proteins of BNT162b2 participant Pfizer Pfizer-BioNTech positive prospective cohort study receiving SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine seroconverted serum sample serum samples study period T-cell immune response T-cell immune responses timepoint vaccination Vaccine waned were measured within 6 months [DOI] 10.1016/j.vaccine.2022.06.016 PMC 바로가기 [Article Type] Article
Optical Biosensor for the Detection of Infectious Diseases Using the Copolymer F8T2 with Application to COVID-19COVID-19에 적용한 공중합체 F8T2를 사용한 감염성 질환 검출을 위한 광학 바이오센서Article Published on 2022-07-292022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-RBD/RBD binding anti-SARS-CoV-2 antibody antibody Antibody binding Antibody detection Antigen application biosensor caused Concentration Copolymer coronavirus COVID-19 COVID-19 negative detection develop effort F8T2 human serum hydrophobic IgG Infectious disease Interaction layer mounted negative sample optical pandemic Photoluminescence photoluminescence. polyclonal Polymer positive positive individuals promote Protein RBD Reactions respiratory SARS-CoV-2 SARS-CoV-2 spike protein secondary antibody sensitivity serum severe acute respiratory syndrome Coronavirus specificity Spike protein the SARS-CoV-2 Volume [DOI] 10.3390/s22155673 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials동종 또는 이종 체계에서 항 SARS CoV-2 백신 SOBERANA 02의 안전성 및 면역원성: 공개 라벨 임상 1상 및 2a상 임상 시험Clinical Trial Published on 2022-07-292022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adaptive adverse event Anti-RBD IgG Antigen clinical trial clinical trials conjugate Conjugate vaccine COVID-19 COVID-19 vaccine D614G delta variant dose doses elicited ELISA evaluate evaluated frequencies Frequency hACE2 Heterologous heterologous immunization Heterologous immunization scheme homologous homologous or heterologous IgG IgG ELISA IIa immune response immune responses immunogenic immunogenicity Immunological response Interaction local pain molecular neutralization neutralized Neutralizing antibodies neutralizing antibody Open-label outcome Panel performed phase Phase I phase IIa Primary outcome progressed protocol protocols RBD receive receiving reduction reported Safe Safety SARS-CoV-2 secondary outcome selected Specific T-cell response subjects Subunit vaccine T-cell T-cell Response T-cells Tetanus tetanus toxoid trials Vaccine variant Volunteer volunteers [DOI] 10.1016/j.vaccine.2022.05.082 PMC 바로가기 [Article Type] Clinical Trial
Urtica dioica Agglutinin: A plant protein candidate for inhibition of SARS-COV-2 receptor-binding domain for control of Covid19 InfectionUrtica dioica Agglutinin: Covid19 감염 통제를 위한 SARS-COV-2 수용체 결합 도메인 억제를 위한 식물성 단백질 후보Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antiviral effect average bind binding binding affinity binding energy binding free energy binding site calculated Cell complex convalescent serum coronavirus docked docking docking result docking results domain Donor donors dynamic effective effective drug effective drugs ELISA ELISA assay enzyme exhibited free energy Gromacs host cell human cells IgG Infection inhibit inhibitory activity Interaction limitation MD simulation mechanism Medicine Medicines MTT Mutation peptide Prevent Previous studies Protein RBD RBD binding RBD complex RBD protein Receptor-binding domain Result S-protein Safe SARS-CoV SARS-CoV-2 Simulation spike Spike protein spike protein of SARS-CoV-2 stability the cell the RBD Toxicity Urtica Vaccine virus was performed was used [DOI] 10.1371/journal.pone.0268156 PMC 바로가기 [Article Type] Article