monocyte – Page 35 – Communicable Diseases Research

Heightened Circulating Interferon-Inducible Chemokines, and Activated Pro-Cytolytic Th1-Cell Phenotype Features Covid-19 Aggravation in the Second Week of Illness

Immunology

Published on 2020-10-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

Article

Published on 2020-10-202022-10-04
Journal: Cell Discovery [Category] 치료제,

[키워드] activated association BALF bioinformatics Blood CCL4 CCL5 CD4 CD8 Cell cell death characterized chemokines correlated COVID-19 COVID-19 patient cytokine DCs dendritic cell effective Frequency healthy controls IFNg Immune cell immune dysfunction immune response immunology indicated Inflammation interferons lung lymphopenia mechanism monocyte monocyte-macrophage mononuclear cell NK cell PBMCs Peripheral blood produced proportion recruitment secreted severe coronavirus disease severe COVID-19 severe COVID-19 patients significantly Single-cell RNA sequencing T cell T cell subset TCR Th1 Th2 TNF Treatment understanding uninfected control
[DOI] 10.1038/s41421-020-00225-2 PMC 바로가기 [Article Type] Article

Unique immunological profile in patients with COVID-19

COVID-19 환자의 독특한 면역 프로필

Clinical Trial

Published on 2020-10-152022-08-13
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19
[DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial

The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)

Article

Published on 2020-10-102022-10-29
Journal: Microorganisms [Category] COVID-19,

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

SARS-CoV-2 및 ACE2 증강으로 유발된 염증은 심각한 COVID-19의 다발성 장기 부전을 유발합니다: 분자 메커니즘 및 의미

Review

Published on 2020-10-082022-09-10
Journal: Inflammation [Category] MERS, 바이오마커,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggravate Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm Cytokines develop downregulation drive Evidence failure functional high mortality host cell host cells Inflammation Inflammatory responses Injury interleukin interleukin-6 lead Lung injury Macrophage macrophages massive mechanism monocyte Monocytes Multiple multiple organ dysfunction multiple organ dysfunction/failure multiple organ failure Necrosis NFκB nuclear Occurrence organ dysfunction organs pandemic pathological change pathological changes patients of COVID-19 receptor released Renin renin-angiotensin system replicate respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe patients Severe patients of COVID-19 Spike protein syndrome TNFα Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha widespread
[DOI] 10.1007/s10753-020-01337-3 PMC 바로가기 [Article Type] Review

IL-6–based mortality risk model for hospitalized patients with COVID-19

Research article

Published on 2020-10-012022-10-05
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커,

[키워드] age albumin Analysis Biomarker Biomarkers C-reactive protein can be used clinical decision Clinical deterioration contributed Coronavirus disease 2019 COVID-19 Cutoff develop diagnosed died discharged distress ferritin fraction global pandemic high accuracy hospital Hospitalization hospitalized patient IL-6 IMPROVE initial lactate dehydrogenase LDH Lymphocyte count monocyte Mortality mortality risk mortality risk model multivariable neutrophil count Neutrophil-to-lymphocyte ratio nonsurvivor objective outcome oxygen oxygen saturation Patient patients with COVID-19 Peripheral blood predict Predictive Predictive model prospective cohort Result risk risk stratification sensitivity severity Spain specificity SpO2/FiO2 survivor the disease with COVID-19
[DOI] 10.1016/j.jaci.2020.07.009 [Article Type] Research article

Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms

Research article

Published on 2020-10-012022-10-05
Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커,

[키워드] analysed antibody panel Antigen approach Biomarker CD11b Cell circulating leukocyte clinically Complement receptor 3 count COVID-19 COVID-19 patient COVID-19 patients cytokine release develop diagnostic eight examined explain feature febrile fibrinogen finding flow cytometry granulocyte healthy volunteers hypoxia hypoxic Immunological memory Immunology and inflammation Increased infected individual Infection Inflammatory innate immune cell innate immune response innate immune system leukocyte leukocyte activation Level memory Mild symptom mild symptoms monocyte natural NK cell over-expression Patient patients with COVID-19 Pneumonia potential therapeutic target Rapid receptor remained required Respiratory complications Respiratory failure specimen subsequent Therapeutics thrombotic understanding Ventilated ventilatory support with COVID-19
[DOI] 10.1016/j.ijid.2020.08.004 [Article Type] Research article

Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness

Article

Published on 2020-09-292022-10-31
Journal: Cells [Category] COVID-19,

Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology

Immunology

Published on 2020-09-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Research Articles

Published on 2020-09-172022-10-28
Journal: Science Immunology [Category] COVID-19, Fulltext, SARS,

[키워드] alteration Analysis Bone marrow CD14 Cell cellular clinical disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease driving elevated enzyme exaggerated immune response expression feature Hospital admission hospitalized patient identify IL-6 immune immune profiling immune response immune signature inflammatory component innate immune IP-10 longitudinal marker MCP-1 median modulation monocyte mononuclear cell myeloid cell neutrophil outcome Patient PBMCs Peripheral blood phenotype reveal serum severe disease severity of COVID-19 Support T cell the healthy therapeutic strategy therapy timepoints Whole blood with COVID-19
[DOI] 10.1126/sciimmunol.abd6197 PMC 바로가기 [Article Type] Research Articles