AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamicsSpecial Issue Papers Published on 2021-09-012022-10-29 Journal: The International Journal of High Performance Computing Applications [Category] COVID-19, [키워드] accelerate AI Complete complex computational virology conformational COVID19 deep learning develop flexible glycan GPU heterogeneous HPC human ACE2 receptor Interaction mechanism modulating molecular molecular dynamics multiscale simulation resource SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral Spike protein Summit the SARS-CoV-2 variety viral infection virus weighted ensemble [DOI] 10.1177/10943420211006452 PMC 바로가기 [Article Type] Special Issue Papers
Synthesis and Biological Evaluation of Honokiol Derivatives Bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones as Potential Viral Entry Inhibitors against SARS-CoV-2Communication Published on 2021-08-312022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease ACE2 ACE2 blocker activities analogue Antiviral antiviral activity antiviral efficacy antiviral molecules Bearing bind binding binding affinity Biological Biosafety Level 3 BLI caused contribute cortex COVID-19 demonstrated derivative develop effective ELISA assay examined Health Honokiol honokiol analogues host cell human Ace2 protein inhibitor inhibitory effect lower binding energy medication molecular docking parental Potential Research SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 viral SARS-CoV-2 virus infection strain synthesis the SARS-CoV-2 virus Viral entry inhibitors [DOI] 10.3390/ph14090885 PMC 바로가기 [Article Type] Communication
Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel군인의 직업 및 인구 통계와 SARS-CoV-2 혈청 IgG의 연관성Research Article Published on 2021-08-302022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] 95% CI aircraft Armed Forces association Biomarker Biomarkers Black race COVID-19 demographic data demographics Disease surveillance elevated ELISA enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays exhibited Follow-up globe highest highlight household size Humoral response humoral responses IgG increased risk Infection information International International airport live SARS-CoV-2 Local moderate MOS neutralizing capacity New York City occupational Odds ratios plaque plaque assays questionnaire Recognition remained Result Risk factors SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 seroprevalence SARS-CoV-2 spike SARS-CoV-2 spike antigen Seropositivity serum serum IgG serum neutralizing capacity significantly spike IgG study population subject were used [DOI] 10.1371/journal.pone.0251114 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicityResearch Article Published on 2021-08-272022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] Affect age Alter Antibody binding antigenic BLI, bio-layer interferometry COVID-19 COVID-19 vaccine Critical cryo-EM, cryo-electron microscopy CTF, contrast transfer function decrease diminishe DSC, differential scanning calorimetry effective vaccine elicit EM, electron microscopy fraction highlighting Laboratory mice Microscopy MONITOR neutralization NS-EM, negative-stain electron microscopy NTD, N-terminal domain PBS, phosphate buffered saline pH-induced folding physiological RBD, receptor-binding domain S2P SARS-CoV-2 SARS-CoV-2 spike significantly Structure susceptible the receptor-binding domain the SARS-CoV-2 Treatment trimeric unfolding virus-neutralizing antibody [DOI] 10.1016/j.jbc.2021.101127 PMC 바로가기 [Article Type] Research Article
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infectionResearch Article Published on 2021-08-272022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] acute COVID-19 administration analyzed antibodies antibody antigenic baseline binding children children with MIS-C clinical response collected coronavirus coronavirus disease correlated correlation COVID-19 determine dose Effect Endemic GMT group healthy children healthy control healthy controls HKU1 Hospitalized IgG antibody Immunity Inflammatory injected injection intramuscular intramuscularly mice MIS-C murine Neutralizing neutralizing antibody Neutralizing antibody response objective original regimen response Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike SARS-CoV-2 spike protein Serologic response significantly higher spike IgG Spike protein syndrome [DOI] 10.1371/journal.pone.0256482 PMC 바로가기 [Article Type] Research Article
Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cellsCorrespondence Published on 2021-08-242022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] ACE2-expressing cell cell death Mechanisms of disease SARS-CoV-2 spike Syncytia [DOI] 10.1038/s41421-021-00310-0 PMC 바로가기 [Article Type] Correspondence
SARS-CoV-2 Proteins Bind to Hemoglobin and Its MetabolitesSARS-CoV-2 단백질은 헤모글로빈과 그 대사산물에 결합합니다Article Published on 2021-08-212022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption affinity column Analysis analyzed approaches bind binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain explain FIVE hematological heme hemin hemoglobin identify in silico analysis in vitro inhibitory effect Interaction M metabolite Microarray motif motifs N N protein N-terminal domain Nsp3 Nsp7 NTD nucleoprotein peptide peptides Plaque assay Protein protein–protein binding Proteins proteomic Proteomic analysis proteomics protoporphyrin RBD RBD region receptor recruit recruitment Replication respiratory S protein SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus spike Spike protein suppressed the N protein the RBD the S protein the spike protein these compound these compounds Vero cells Viral viral replication virus was used [DOI] 10.3390/ijms22169035 PMC 바로가기 [Article Type] Article
Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM RefinerArticle Published on 2021-08-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Amplicon Amplicon sequencing analyses B.1 B.1.1.7 chimeric computation coronavirus coronavirus 2 D614G domain function Gamma metagenomics Molecular epidemiology monitoring novel P.1 PCR polymerase chain Population Program respiratory SAM SARS-CoV-2 SARS-CoV-2 spike sequencing method Spread variant variants of concern variety viral population dynamics Viral variants wastewater [DOI] 10.3390/v13081647 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Pseudoviruses: A Useful Tool to Study Virus Entry and Address Emerging Neutralization Escape PhenotypesArticle Published on 2021-08-162022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] address angiotensin-converting enzyme-2 antibody B.1.1.7 B.1.351 BSL-2 candidate vaccine Cell clinical trial convalescent COVID-19 develop disease effective escape expressing Genetic variant globe hACE2 help Lentiviral vector less MLV vector monoclonal antibody neutralization neutralization ability Neutralization assay Neutralizing antibodies NIBSC PBNA Phenotypes Prophylactic pseudovirus R 2 raising reagent recent receptor Research SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variants sensitivity sera severity South Africa spike susceptible time-consuming Transmissibility United Kingdom unmet need variants variants of concern virus VoC VOCs [DOI] 10.3390/microorganisms9081744 PMC 바로가기 [Article Type] Article
Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases자가면역 류마티스 질환이 있는 소아 및 청소년의 인간 코로나바이러스에 대한 유리한 항체 반응Clinical and Translational Article Published on 2021-08-142022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단, [키워드] Abstract acute respiratory syndrome Adolescent Affect age antibodies antibody Antibody Response Arthritis Autoimmune Cancer Research UK children class-switching collected common-cold comparable Context coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic cross-reactive cure dermatomyositis determine difference elevated examined exhibited finding foundation Francis Crick funding HCoV-OC43 HCoV-OC43 spike healthy control human coronavirus Humoral immunity IgG IgG antibody immune immune dysfunction Immunoglobulin Immunosuppression Immunosuppressive treatment infect Infection Inflammatory juvenile idiopathic arthritis lack Lupus Medical Research Council MIS-C myositis NIHR nucleoprotein nucleoprotein of SARS-CoV-2 pandemic Patient patients prevalent raising receive response rheumatic disease Rheumatic diseases risk of COVID-19 SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike seasonal coronavirus sera severe symptom shielding Spike protein Street supported syndrome systemic lupus erythematosus the antibody response Treatment UCLH Wellcome Trust [DOI] 10.1016/j.medj.2021.08.001 PMC 바로가기 [Article Type] Clinical and Translational Article