Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine
Research Article
[키워드] addition
against SARS-CoV
analyzed
biosafety
carboxy-terminal region
causing
Cell culture
chimeric
contributed
coronavirus
Coronaviruses
CoVs
deleted
Deletion
duplication
E gene
E protein
effective
epidemic diarrhea
full-length
Genetic
Host
identification
immune response
in vitro
in vivo
indicated
induce
insertion
interferon response
introduced
Live attenuated vaccine
manuscript
mechanism
membrane
MERS-CoV
mice
Middle East
molecular mechanism
morbidity and mortality
motif
mutant virus
mutated
Mutation
not affect
parental
passage
pathogenicity
PEDV
phenotype
Protective
Protein
provided
recombinant
remained
restored
resulting
reversion
Safe
SARS-CoV
SARS-CoV vaccine
sequence
stability
STABLE
syndrome
the vaccine
therapy
transmembrane protein
understanding
Vaccine
vaccine candidate
Vaccines
variant
virulence
virulent
virus
virus attenuation
virus genome
[DOI] 10.1371/journal.ppat.1005215 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1005215 PMC 바로가기 [Article Type] Research Article