The effect of a single dose of BNT162b2 vaccine on the incidence of severe COVID-19 infection in patients on chronic hemodialysis: a single-centre studyObservational Study Published on 2022-01-012022-10-05 Journal: Clinical and experimental nephrology [Category] 임상, [키워드] Administered allergic BNT162b2 BNT162b2 vaccine clinically Control COVID-19 COVID-19 infection criteria death dialysis dose Efficiency eligible Enrollment ESRD Hemodialysis incidence Infection intramuscularly less life-threatening Local of BNT162b2 offer Patient patients primary end-point retrospective screened Severe COVID-19 Infection Side-effect single dose survival rate systemic reaction the vaccine unit vaccination Vaccine vaccine dose [DOI] 10.1007/s10157-021-02118-4 PMC 바로가기 [Article Type] Observational Study
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trialRandomized Controlled Trial Published on 2022-01-012022-10-04 Journal: Intensive care medicine [Category] Fulltext, SARS, 임상, [키워드] adjusted analysed analyses Bayesian Bayesian analysis Bayesian model benefit blinded clinically conducted coronavirus disease Corticosteroids COVID COVID-19 CrI Critical illness days alive Dexamethasone effect size facilitate hospital hypoxaemia intention-to-treat population International Interpretation interval mean difference median Mortality outcome Patient patients patients with COVID-19 posterior probability Primary outcome Probability randomised reached Result risk Sensitivity analyses serious adverse reaction statistical significance Support threshold Trial [DOI] 10.1007/s00134-021-06573-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Development of RNA-Based Assay for Rapid Detection of SARS-CoV-2 in Clinical SamplesArticle Published on 2022-01-012022-11-15 Journal: Intervirology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome aggregation caused clinical clinical sample clinically Colorimetric test Community coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 negative detect detection Detection limit development diagnosed Diagnosis gold standard include less management nasopharyngeal optical outbreak pandemic pandemic coronavirus platform polymerase chain positive COVID-19 Rapid retained Ribonucleic acid RNA sample RNA-dependent RNA polymerase Sample SARS-CoV-2 SARS-CoV-2 RNA sensitivity specificity Spread subject women [DOI] 10.1159/000522337 PMC 바로가기
Erythema Multiforme-Like Presentation in an Asymptomatic COVID-19 PatientInternal Medicine Published on 2021-12-292022-10-31 Journal: Cureus [Category] COVID-19, [키워드] alcohol Asymptomatic celexa citalopram Clinical course Clinical practice clinically coronavirus disease COVID-19 COVID19 discharge disease drugs Erythema erythema multiforme etiologies female Follow-up Health herpes simplex hospital Hospital stay initial lesion lyrica Manifestations mirtazapine Mycoplasma pneumoniae negative test new virus oxcarbazepine Oxygenation Patient polymerase chain positive presentation primary care SARS-CoV-2 seroquel smoking steroid suboxone Symptomatic treatment Symptoms the patient Variation virus [DOI] 10.7759/cureus.20814 PMC 바로가기 [Article Type] Internal Medicine
Screen Use and Mental Health Symptoms in Canadian Children and Youth During the COVID-19 PandemicResearch Published on 2021-12-282022-10-29 Journal: JAMA Network Open [Category] Coronavirus, SARS, [키워드] activity age Anxiety asked association Canada children children’s health clinically Cohort cohort study cohorts Community Complete conducted COVID-19 COVID-19 pandemic Depression determine develop finding form help hyperactivity Importance Intervention irritability longitudinal longitudinal cohort study male participant measure media mental health objective observation Older outcome pandemic parent participant Point poor mental health problem problems promote questionnaire Relevance repeated repeated measure required Research Result Screen setting significantly higher Support Symptom symptoms of depression understanding variable Youth [DOI] 10.1001/jamanetworkopen.2021.40875 PMC 바로가기 [Article Type] Research
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsShort Reports Published on 2021-12-282022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses [DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports
Aerosol release, distribution, and prevention during aerosol therapy: a simulated model for infection control에어로졸 방출, 분포 및 예방 중에 에어로졸 요법 : 감염 제어를위한 시뮬레이션 된 모델Research Article Published on 2021-12-282022-08-31 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition aerosol aerosol therapy aerosol visualization Aerosols airway airways bacterial filter bystander Caregivers clinically Combination Concentration conditions COVID-19 dispersion distance distribution examined exposure to fugitive emissions healthcare worker Image infection control Laser optical Particles Patient reduce reducing respiratory Schlieren imaging significantly subsequent supplemental air therapy treat Treatment vibrating mesh nebulizer Viral viral infections was used were assessed were measured [DOI] 10.1080/10717544.2021.2015482 PMC 바로가기 [Article Type] Research Article
Efficacy and Safety of Anticoagulation Treatment in COVID-19 Patient Subgroups Identified by Clinical-Based Stratification and Unsupervised Machine Learning: A Matched Cohort StudyMedicine Published on 2021-12-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress Admission Analysis anticoagulation ARDS association benefit Biomarkers bleeding bleeding event bleeding events characterized circulation clinical clinical feature clinically Cluster Clustering Coagulation Cohort Coronavirus disease 2019 COVID-19 COVID-19 patients Critical Critical case Critically ill Critically ill patient D-dimer level Efficacy elevated excessive inflammation Hospital stay Identified identify In-hospital death incidence Inflammation investigated kidney liver dysfunction machine machine learning analysis major bleeding Matched Mild Mortality multiple organ dysfunction neurologic no increase outcome outcomes Patient patients patients with COVID-19 Probability retrospective cohort study risk Safety severe ARDS Severe case single-center Stratification subgroup subgroup analysis syndrome Tongji Hospital Treatment unsupervised learning Unsupervised machine learning was used Weighting while [DOI] 10.3389/fmed.2021.786414 PMC 바로가기 [Article Type] Medicine
Learning From Biological and Computational Machines: Importance of SARS-CoV-2 Genomic Surveillance, Mutations and Risk Stratification생물학 및 전산 기계에서 배우기: SARS-CoV-2 게놈 감시, 돌연변이 및 위험 계층화의 중요성Cellular and Infection Microbiology Published on 2021-12-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Algorithm approach best Biological blood urea breathlessness C-reactive protein C-reactive protein (CRP characteristic Clinical data clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation cough country COVID-19 dataset demonstrated develop diagnostic disease manifestation disease severity Evolution feature FIVE Frequency functional genomic Genomic analysis genomic mutations genomic sequencing Genomic surveillance healthcare highlight Importance India information learning leukocyte machine learning management ML model ML models Mutation Observing pandemic parameter parameters pathogen Patient patient severity performed physical symptoms predict Probability receiver operating characteristic resource respiratory respiratory rate Respiratory Support risk Risk assessment risk stratification ROC SARS-CoV-2 SARS-CoV-2 genomic surveillance severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Severe patient significantly singular statistical statistical analysis Symptom tested the patient urea variants variants of concern variants of interest virus VOCs VOIs [DOI] 10.3389/fcimb.2021.783961 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Commercial AI solutions in detecting COVID-19 pneumonia in chest CT: not yet ready for clinical implementation?흉부 CT에서 COVID-19 폐렴을 감지하는 상용 AI 솔루션: 아직 임상 구현 준비가 되지 않았습니까?Imaging Informatics and Artificial Intelligence Published on 2021-12-232022-09-10 Journal: European Radiology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Analysis artificial intelligence AUC benefit calculated change Chest Chest CT clinically Computed tomography condition conditions COVID-19 COVID-19 pandemic COVID-19 pneumonia dataset diagnosing evaluate evaluated GGO GGOs Ground-glass opacities ground-glass opacity highlight Image analysis lung many cases microbiologically negative objective other conditions Patient Pneumonia Point positive Positive predictive value Predictive Predictive value predictive values radiology randomized trials ranged remained researcher Result sensitivity Sensitivity and specificity specificity subgroup analysis supplementary material Trial [DOI] 10.1007/s00330-021-08409-4 PMC 바로가기 [Article Type] Imaging Informatics and Artificial Intelligence