Drug repurposing – Page 36 – Communicable Diseases Research

Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm

Article

Published on 2021-04-012023-07-13
Journal: Chemical biology & drug design [Category] SARS,

[키워드] 2019nCoV antiviral drugs cordycepin coronavirus Drug repurposing
[DOI] 10.1111/cbdd.13812

Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach

Article

Published on 2021-04-012023-07-13
Journal: Journal of biomolecular structure & dynamics [Category] SARS,

[키워드] 3CLpro Corona virus Drug repurposing MD simulation Remdesivir SARS-CoV-2 Virtual screening
[DOI] 10.1080/07391102.2020.1751298

Identification of FDA approved drugs against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and 3-chymotrypsin-like protease (3CLpro), drug repurposing approach

Review

Published on 2021-03-312023-06-16
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS,

[키워드] 3CLpro COVID-19 Drug repurposing FDA-approved drugs RdRP SARS-CoV-2
[DOI] 10.1016/j.biopha.2021.111544 PMC 바로가기 [Article Type] Review

Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor

Research Article

Published on 2021-03-292022-10-04
Journal: Biochemistry and Biophysics Reports [Category] 신약개발,

[키워드] Abstract ACE ACE1 ACE2 addition Amino acid Analysis angiotensin approved drug binding Cell comparable coronavirus 2 COVID-19 distribution domain Drug repurposing entry of SARS-CoV-2 enzyme epithelial expression homolog host cells host-virus interaction human cells human lung Image Infection Interaction interfere low expression organized peptidase predict primary sequence Proteins RBD receptor Receptor binding domain Region reported repurposing respiratory S protein same order SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein similarities similarity spike glycoprotein Spike protein the SARS-CoV-2 tissue Transmission variety viral spike protein X-ray crystallographic structure
[DOI] 10.1016/j.bbrep.2021.100982 PMC 바로가기 [Article Type] Research Article

Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform

AI 통합 바이오시뮬레이션 플랫폼을 사용한 코로나19 치료를 위한 폐 고혈압 치료제 용도 변경 및 약물 개발 가속화

Article

Published on 2021-03-292022-08-31
Journal: Molecules [Category] 신약개발, 치료제,

[키워드] accelerated ACE ACE inhibitor ACE inhibitors ACEi angiotensin Angiotensin-converting enzyme approach artificial intelligence blocker calcium calcium channel calcium channel blockers CCB CCBs cellular entry Combination Compound conducted COVID-19 COVID-19 pandemic COVID-19 pathogenesis Critical dataset development drug Drug repurposing drug therapy Effect enzyme hypertension implicated in silico in vitro in vivo investigated pathway Pathways penetration platform pulmonary pulmonary hypertension RAS reached Renin renin-angiotensin system Replication repurposing SARS-CoV-2 shown systemic therapy target therapeutic therapy tissue tissues virus
[DOI] 10.3390/molecules26071912 PMC 바로가기 [Article Type] Article

Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research

Article

Published on 2021-03-272023-07-02
Journal: Briefings in Bioinformatics [Category] SARS,

[키워드] COVID-19 drug combination Drug repurposing systems pharmacology analysis virus knowledgebase
[DOI] 10.1093/bib/bbaa155 PMC 바로가기

In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2

SARS-CoV-2에 대한 Ketotifen, Indomethacin 및 Naproxen 단독 및 조합의 항바이러스 활성 시험관 내 평가

Article

Published on 2021-03-262022-09-10
Journal: Viruses [Category] SARS, 신약개발, 치료제,

Molecular Basis of the Therapeutical Potential of Clove ( Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility

정향(Syzygiumaromaticum L.)의 치료 가능성에 대한 분자적 기초 및 항-COVID-19 유용성에 대한 단서

Review

Published on 2021-03-262022-09-10
Journal: Molecules [Category] 신약개발, 치료제,

SAveRUNNER: an R-based tool for drug repurposing

Software

Published on 2021-03-232022-10-27
Journal: BMC Bioinformatics [Category] COVID-19,

SAveRUNNER: an R-based tool for drug repurposing

Software

Published on 2021-03-232022-10-27
Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS,