epitope – Page 36 – Communicable Diseases Research

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Article

Published on 2021-11-222022-10-04
Journal: Communications Biology [Category] MERS, SARS, 바이오마커, 변종, 진단,

Dynamics of Neutralizing Antibody Responses Following Natural SARS-CoV-2 Infection and Correlation with Commercial Serologic Tests. A Reappraisal and Indirect Comparison with Vaccinated Subjects

천연 SARS-COV-2 감염 후 중화 항체 반응의 역학 및 상업적 혈청 학적 시험과의 상관 관계.백신 접종 된 대상과의 재평가 및 간접 비교

Comparative Study

Published on 2021-11-222022-09-01
Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] Accuracy administration antibody binding Binding assays blood sample Blood samples BNT162b2 calculated Cohort COVID-19 COVID-19 patients cut-off cut-offs detect Dynamics epitope experiment first dose Follow-up gold gold standard healthcare worker Healthcare workers IgA IgG IgM IMPROVE majority NAb NAbs natural Neutralising Antibodies neutralization neutralization test neutralizing antibody neutralizing assays neutralizing capacity of BNT162b2 participant Patient plaque reduction neutralization Plaque reduction neutralization test positive PRNT pseudovirus pseudoviruses response RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secure serologic Serological assay serological assays subjects surrogate virus neutralization test sVNT symptoms onset target cells the SARS-CoV-2 total antibodies total antibody two-dose regimen virus virus neutralization test was performed
[DOI] 10.3390/v13112329 PMC 바로가기 [Article Type] Comparative Study

Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans

Sierra Leoneans의 Covid-199 혈액 샘플에서 SARS-COV-2 및 MERS-COV에 대한 교차 반응성 항체

Article

Published on 2021-11-212022-09-01
Journal: Viruses [Category] MERS, SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age American Americans antibodies binding antibody binding Blood donors blood sample Blood samples collected Contact contribute coronavirus Coronavirus-2 country COVID-19 COVID-19 case COVID-19 caseloads and deaths cross-protective immunity cross-react death Ebola enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes had more healthy blood donor healthy blood donors humans induce infect Lassa fever MERS-CoV MERS-CoV pseudovirus middle Middle Eastern respiratory syndrome coronavirus neutralized Neutralizing antibodies neutralizing antibody not differ pandemic pre-existing immunity pre-existing immunity to coronaviruses presence of antibody Protein pseudovirus neutralizing antibodies recombinant antigens reduced Region reported Reporting respiratory respiratory syndrome coronavirus response Result Sample SARS-CoV SARS-CoV-2 SARS-CoV-2 pseudovirus seasonal coronavirus seasonal coronaviruses Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Sex sub-Saharan Africa subject survivor The United States United States were assessed
[DOI] 10.3390/v13112325 PMC 바로가기 [Article Type] Article

Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization

기존 교차 반응성 항체 반응은 비활성화된 COVID-19 백신 유도 중화에 큰 영향을 미치지 않습니다

Immunology

Published on 2021-11-192022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome analyzed antibody Antibody Response collected conserved CoV COVID-19 COVID-19 vaccine cross-reactive antibody cross-reactive antibody immunity distribution dose epitope Evidence fluorescence intensity greater healthy volunteer Humoral immunity IgG and IgM Immunity immunization Impact inactivated Inactivated vaccine increase in intensity linear neutralization not differ participant peptide peptides pre-vaccination previous study produced Protective provide recent Region Research response responses responses against S2 subunit SARS-CoV-2 SARS-CoV-2 vaccine seasonal coronavirus sera significantly stimulate the S protein vaccinee whole-virion SARS-CoV-2 vaccine
[DOI] 10.3389/fimmu.2021.772511 PMC 바로가기 [Article Type] Immunology

Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARS

SARS-CoV-2 스파이크 단백질에 대한 항체 검출 및 SARS 회복 15년 후의 말초혈액 단핵세포 전사체 프로파일 분석

Cellular and Infection Microbiology

Published on 2021-11-182022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Against antibodies antibody binding cellular entry cellular immunity chemiluminescence chemokine clinical manifestations collected conducted convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity cytokine detection elicit epitope Epitopes exhibited expressed Genes heatmap homology immune immune cross-reactivity Immune status Immunity immunoassay in vitro inhibit interferon gamma microsphere mononuclear cell mRNA mRNAs pandemic patients with COVID-19 patients with SARS PBMC PBMCs peptide peptide epitope peripheral Peripheral blood Peripheral blood mononuclear cells Post-infection profile protein sequences Research respiratory responses SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein serum serum antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction significantly spike Spike protein stimulated the SARS-CoV-2 transcriptomic profile was obtained were used Year
[DOI] 10.3389/fcimb.2021.768993 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Allelic variation in class I HLA determines CD8 + T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Research Articles

Published on 2021-11-182022-11-01
Journal: Science Immunology [Category] COVID-19,

Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody

인간 항체에 의한 SARS-CoV-2의 보존된 취약성 사이트 발견

Article

Published on 2021-11-172022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] Affect Alpha antibody antiviral drugs attachment B.1.1.7 B.1.351 B.1.617.2 Beta characterized concern conserved convalescent Convalescent patients COVID‐19 patient COVID‐19 cross‐reactivity cross‐active neutralizing antibody Delta Delta variants destruction of spike electron microscopy engage epitope epitope distal escape mutants functional Gamma generate hamsters host cell host cell receptor mechanism Microbiology, Virology & Host Pathogen Interaction Microscopy monoclonal antibody MOST motif mutable mutants Mutation neutralization neutralize neutralized Neutralizing antibodies neutralizing antibody P.1 predicted RBD RBM receptor‐binding domain receptor‐binding domain reduce residue residues SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike spike Strains structural biology the RBD the Spike variants variants of concern Viral viral replication
[DOI] 10.15252/emmm.202114544 PMC 바로가기 [Article Type] Article

Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines—A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters

상이한 CovID-19 백신에서 체액 및 세포 면역 반응의 역할을 해독하는-Roborovski Dwarf 햄스터에서 백신 후보 유전자 비교

Article

Published on 2021-11-162022-09-01
Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료법,

[키워드] adenoviral vector adenoviral vectors animal model Antigen candidate cellular immune responses compensated COVID-19 dwarf dwarf hamster Efficacy epitope Epitopes Evolution exposure to facilitate focus full-length full-length spike protein glycoprotein hamster immune response immune responses immunogenicity impairing Inactivated Vaccines membrane protein Mutation Neutralizing antibodies neutralizing antibody new SARS-CoV-2 nucleocapsid protein other SARS-CoV-2 genes prevented protective effect Protective effects provided question RBD Receptor binding domain response risk robust role SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 genes SARS-CoV-2 vaccine SARS-CoV-2 variants selected severe pneumonia Spike protein spike-based vaccines Spread susceptible T-cell Response the spike protein triggered Vaccine Vaccine design vaccine genes Vaccines variants virus replication
[DOI] 10.3390/v13112290 PMC 바로가기 [Article Type] Article

Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike

스파이크의 독특한 에피토프를 표적으로 하는 항체에 의한 우려의 신흥 SARS-CoV-2 변이체의 교차 중화

Clinical Trial

Published on 2021-11-162022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 비임상, 임상, 진단,

[키워드] (Alpha) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha antibody B.1.1.7 B.1.617.2 binding breath concern convalescent coronavirus Critical disrupt distinct domain Donor epitope Epitopes Human Humoral immunity immune memory Immunity induce Infectious disease K417 mAb mAbs monoclonal antibodies monoclonal antibody Mutation natural infection neutralize Neutralizing Neutralizing antibodies neutralizing antibody P.1 pandemic prototype RBD Receptor binding domain Region respiratory SARS-CoV-2 SARS-CoV-2 spike Single Cell spike Spike protein target targeting the SARS-CoV-2 the spike protein Transmissibility vaccination variant variants variants of concern Viral Viral variants VOCs
[DOI] 10.1128/mBio.02975-21 PMC 바로가기 [Article Type] Clinical Trial

Immunoinformatics mapping of potential epitopes in SARS-CoV-2 structural proteins

Research Article

Published on 2021-11-152022-10-28
Journal: PLoS ONE [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Algorithm Antibody detection antigenic approved assays coronavirus coronavirus disease COVID-19 COVID-19 vaccine diagnostic effective effective vaccine Efficacy epitope epitope-based vaccines experimental evidence experimental validation facilitate Genetic immune immune response immunological Infection Multi-epitope vaccine N protein non-allergenic patients with COVID-19 platform potential immune epitope predict predicted PROTECT reduce risk Safe SARS-CoV SARS-CoV-2 selected serological structural protein structural proteins Support T cell T-cell epitope target the vaccine Vaccine vaccine candidate variants of SARS-CoV-2
[DOI] 10.1371/journal.pone.0258645 PMC 바로가기 [Article Type] Research Article