Results of a European-Wide External Quality Assessment (EQA) Scheme for Serological Detection of Anti-SARS-CoV-2 (CoVimm)-Pitfalls of Routine ApplicationAnti-SARS-CoV-2(CoVimm)의 혈청학적 검출을 위한 유럽 전역 외부 품질 평가(EQA) 계획의 결과-일상 적용의 함정Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition Analysis analytical methods analytical techniques anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody application assessment biospecimen clinically comparability COVID-19 detection differentiation EQA Europe External external quality assessment scheme external quality control harmonization heterogeneity IgG IgG antibodies IgG antibody immunoassays implication Interpretation introduced Laboratory lack measure new SARS-CoV-2 nucleocapsid pace participated proficiency testing Quality Quality assurance reliability reported Result routine routine care SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 virus serological Serological testing specific IgG antibodies Spike protein standard care Standardization test performance test results thresholds total antibody variety virus [DOI] 10.3390/v14081662 PMC 바로가기 [Article Type] Article
Urtica dioica Agglutinin: A plant protein candidate for inhibition of SARS-COV-2 receptor-binding domain for control of Covid19 InfectionUrtica dioica Agglutinin: Covid19 감염 통제를 위한 SARS-COV-2 수용체 결합 도메인 억제를 위한 식물성 단백질 후보Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antiviral effect average bind binding binding affinity binding energy binding free energy binding site calculated Cell complex convalescent serum coronavirus docked docking docking result docking results domain Donor donors dynamic effective effective drug effective drugs ELISA ELISA assay enzyme exhibited free energy Gromacs host cell human cells IgG Infection inhibit inhibitory activity Interaction limitation MD simulation mechanism Medicine Medicines MTT Mutation peptide Prevent Previous studies Protein RBD RBD binding RBD complex RBD protein Receptor-binding domain Result S-protein Safe SARS-CoV SARS-CoV-2 Simulation spike Spike protein spike protein of SARS-CoV-2 stability the cell the RBD Toxicity Urtica Vaccine virus was performed was used [DOI] 10.1371/journal.pone.0268156 PMC 바로가기 [Article Type] Article
A gold nanoparticle-protein G electrochemical affinity biosensor for the detection of SARS-CoV-2 antibodies: a surface modification approachSARS-CoV-2 항체 검출을 위한 금 나노입자-단백질 G 전기화학적 친화성 바이오센서: 표면 변형 접근법Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] alcohol anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody approach biosensor blocking agent change Community COVID-19 demonstrated detect determine electrode ELISA assay fused gold horseradish peroxidase IDE IgG Modification positive probe Protein protein G purified S protein SARS-CoV-2 sensitivity sera serum spike Spread VINYL ALCOHOL were used [DOI] 10.1038/s41598-022-17219-7 PMC 바로가기 [Article Type] Article
High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccinationCOVID-19 예방 접종이 시작되기 전에 카자흐스탄 카라간다에서 높은 SARS-CoV-2 혈청 유병률Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI Administered Antibody-mediated immunity appear Asia asymptomatic subjects capture Clinical characteristics Cohort collected Continuous correlated COVID-19 COVID-19 transmission COVID-19 vaccination death demographic and clinical characteristics detect detectable effort IgA IgG Immunity Infection Kazakhstan mitigate nasopharyngeal swabs National pandemic participant PCR-negative performed positive Prevalence provide public health Questionnaires recruited reported respiratory Respiratory illness RT-qPCR SARS-CoV-2 SARS-CoV-2 seroprevalence serological assays serological surveillance Serologically Seropositivity subject subset Swab tested the antibodies thresholds titre vaccination Virus neutralization were used [DOI] 10.1371/journal.pone.0272008 PMC 바로가기 [Article Type] Article
Longitudinal monitoring of SARS-CoV-2 spike protein-specific antibody responses in Lower AustriaLower Austria에서 SARS-CoV-2 스파이크 단백질 특이적 항체 반응의 종단적 모니터링Article Published on 2022-07-272022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activities activity Analysis analyzed antibody Antibody Response Community comprehensive view correlated COVID-19 eight hotspot IgA IgA level IgG IgG levels immune responses Immunoglobulin immunoglobulin A Infection infections longitudinal Lower participant Participants peptides positive reduction in remained reported SARS-CoV-2 SARS-CoV-2 spike significantly T cell the receptor-binding domain the spike protein Wachau [DOI] 10.1371/journal.pone.0271382 PMC 바로가기 [Article Type] Article
Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers의료 종사자의 BNT162b2 추가 접종 후 면역원성 평가Article Published on 2022-07-262022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] BNT162b2 booster booster vaccination Contact contact with exposure to first vaccination followed by HCW healthcare worker Healthcare workers humoral Humoral response IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgG level IgG levels immune response Immunity immunogenicity implementation increase in Infection Measures new virus pandemic patients Registered restored SARS-COV-2 infection significantly statistically subject the antibody vaccination Vaccine variants virus [DOI] 10.1038/s41598-022-16759-2 PMC 바로가기 [Article Type] Article
Post-vaccination antibody evaluation for nosocomial SARS-CoV-2 delta variant breakthrough infection병원 내 SARS-CoV-2 델타 변이형 돌발성 감염에 대한 백신 접종 후 항체 평가Observational Study Published on 2022-07-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S IgG Anti-spike anti-spike antibody antibody Asymptomatic B.1.617.2 BNT162b2 booster vaccination Breakthrough infection Care Casirivimab characterized collected coronavirus Course Delta variants diagnosed Diagnosis eight estimation geometric mean geometric mean titer GMT hospital Humoral immunity IgG Imdevimab Infection Inpatient LAMP Loop-mediated isothermal amplification lowest measurement Mild mild to moderate mild to moderate severity moderate monoclonal antibody mRNA vaccination nosocomial observational study outbreak public health quantified RBD protein remained respiratory retrospective risk RT-PCR SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing serological serum sample serum samples Seven severe acute respiratory syndrome Coronavirus severity therapy Treatment uninfected vaccination variant virus viruses was done whole-genome sequencing [DOI] 10.1371/journal.pone.0272056 PMC 바로가기 [Article Type] Observational Study
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19항 카디오리핀 IgG 자가항체는 심각한 COVID-19에서 순환하는 세포외 DNA와 연관됩니다Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] analyzed Anticoagulant association autoantibody circulating citrullinated histone citrullinated histones collected COVID-19 COVID-19 severity disease severity exacerbate extracellular DNA glycoprotein IgA IgG IgG and IgM IgM investigated Lupus lupus anticoagulant marker mild patients NET neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Patient patients with COVID-19 positive patient positive patients Prevalence prothrombin SARS-CoV-2 sera severe COVID-19 severe disease Severe patient severe patients severity the disease with COVID-19 [DOI] 10.1038/s41598-022-15969-y PMC 바로가기 [Article Type] Article