Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with MigraineArticle Published on 2021-12-162022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] administration attack attacks Characteristics clinical parameter clinician collected data conscious COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine demographics Effect Facebook General population group headache health-care inflammatory mediator interferon Italian long-lasting migraine migraine with aura migraine without aura Patient patients Prevalence questionnaire Randomized controlled trials reduce reported resource severity vaccination Vaccine vaccine dose worsening [DOI] 10.3390/jcm10245914 PMC 바로가기 [Article Type] Article
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection바이러스 유래 마이크로 RNA는 SARS-CoV-2 감염 시 면역 반응 유전자를 표적으로 한다Article Published on 2021-12-162022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′UTR Argonaute conserved COVID‐19 COVID‐19 patients COVID‐19 cultured cells Dicer enzyme evade expression help Host Host immune response host immune responses host miRNA human cell identify immune response immune response gene immune response genes immune responses infected cell infected cells innate immune response interfere interferon interferon response isoform Microbiology, Virology & Host Pathogen Interaction microRNA miRNA miRNAs Nasopharyngeal swab nasopharyngeal swabs Patient predominant Proteins repress represse RNA Biology SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sequence small RNA Small RNAs target transcript Viral viral genome viral miRNA [DOI] 10.15252/embr.202154341 PMC 바로가기 [Article Type] Article
The impact of therapeutics on mortality in hospitalised patients with COVID-19: systematic review and meta-analyses informing the European Respiratory Society living guideline코로나19 입원환자 사망률에 대한 치료제의 영향: 유럽호흡기학회 생활지침을 알려주는 체계적인 검토 및 메타분석Review Published on 2021-12-152022-09-11 Journal: European respiratory review : an official journal [Category] SARS, 치료제, [키워드] anti-IL-6 receptor Anti-inflammatory Anti-viral Azithromycin Colchicine comparator conducted coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 Dexamethasone Effect estimate European Evidence guideline high mortality rate hospitalised patient Hospitalised patients Hydroxychloroquine identify inclusion criteria interferon International Intervention Lopinavir Lopinavir/ritonavir Meta-analysis monoclonal antibodies monoclonal antibody monoclonal antibody therapy Mortality other treatments outcome Patient question Random-effects meta-analysis randomised controlled trial Randomised controlled trials recommendation Remdesivir respiratory Ritonavir Society Support systematic review systematic reviews therapy These data Treatment use of corticosteroids was used with COVID-19 [DOI] 10.1183/16000617.0171-2021 PMC 바로가기 [Article Type] Review
Genetic Variants and Immune Responses in a Cohort of Patients With Varicella Zoster Virus Encephalitis수두대상포진 바이러스 뇌염 환자 집단에서의 유전적 변이와 면역 반응Article Published on 2021-12-152023-05-31 Journal: The Journal of Infectious Diseases [Category] 대상포진, 두창, 수두, 홍역, [키워드] autophagy Inborn error of immunity interferon Varicella zoster virus whole exome sequencing [DOI] 10.1093/infdis/jiab254
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral InfectionsArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect Analysis Antiviral antiviral drug combination antiviral property Calu-3 cell changes in clinical development Combination concentrations convalescent serum coronavirus cycloheximide demonstrated drug effective EIDD-2801 HCV hepatitis C virus hepatitis E virus HIV homeostasis Human immunodeficiency virus IFN IFNs IFNα in vitro indicated influenza A virus interferon interferon-alpha lung organoids metabolomic NITD008 organoids Other protein synthesis Remdesivir Replication ribavirin SARS-CoV-2 Side effects suppressed synergistic target tested therapeutic potential tolerable Transcription uninfected cell viral infections Viral RNA while [DOI] 10.3390/v13122489 PMC 바로가기 [Article Type] Article
Foxp3 + CD4 + regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigensFoxp3 + CD4 + 조절 T 세포는 새로운 SARS-CoV-2 항원에 대한 항원 특이적 면역을 유도하는 수지상 세포를 제어합니다Research Article Published on 2021-12-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] absence activate activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant adjuvants Administered administration antibody Antigen antigens approach Autoimmune diseases B cell responses CD4 CD8 cells cellular immunity Combination coronavirus DCs dendritic cell dendritic cells draining lymph node draining lymph nodes effective Efficacy ENhance examined expressing follicular FOXP3 Germinal center help helper T cell highlight humoral immune response immune responses Immunity immunological immunological tolerance IMPROVE induce initiated interferon interferon-γ investigated live SARS-CoV-2 lymph nodes maturation mechanisms mice naïve T cells neutralized Neutralizing antibodies neutralizing antibody present antigen prevented produced Protective receptor Regulatory respiratory response responses SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike protein SARS-CoV-2 variants self-tolerance severe acute respiratory syndrome Coronavirus Spike protein stimulate suppress T cell T cells therapy These data transcription factor Transient Treg Treg cell Treg cells vaccination Vaccine variants [DOI] 10.1371/journal.ppat.1010085 PMC 바로가기 [Article Type] Research Article
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adultsResearch article Published on 2021-12-092022-10-05 Journal: iScience [Category] 바이오마커, [키워드] activated Adults Asymptomatic build children CIITA correlated COVID-19 COVID-19 disease severity cytokine disease elevated Genes IFN IFN response immunology indicated interferon inverse correlation Patient patients predict SARS-CoV-2 selected severe COVID-19 severe disease severity SOCS1 Virology with mild disease [DOI] 10.1016/j.isci.2021.103595 [Article Type] Research article
Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort studyArticle Published on 2021-12-092022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] age Anti-viral immune response Anti-viral immunity chemokine Clinical outcome Cohort cohort study Critical female Hospitalized hypothesised IFN IFN-α IFN-β IFN-γ immune response immunology infancy Infectious diseases Innate innate immune response Innate immunity interferon investigated male males mechanism mononuclear cell morbidity and mortality participant Peripheral blood respiratory infection respiratory syncytial virus respiratory virus Respiratory virus infections response responses SARS-CoV-2 Sex difference stimulated virus [DOI] 10.1038/s41598-021-03044-x PMC 바로가기 [Article Type] Article
Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses산모의 SARS-CoV-2 감염은 성적으로 이형 태반 면역 반응을 유발합니다Article Published on 2021-12-092022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Affect Alter Antibody titers antibody transfer antiviral response coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease elicit examined expression Fc receptors feature fetal immune response immune responses implicated individual innate immune response interferon interferon response interferon-stimulated gene interleukin interleukin-10 Intersection ISG ISGs male males Maternal mechanism modulator placental placental tissue pregnancies Pregnancy pregnant pregnant women Prevalence Proteins receptor respiratory response responses SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2–specific antibody severe acute respiratory syndrome Coronavirus severity Sex Sex difference shown the interferon transfer up-regulation viral-induced [DOI] 10.1126/scitranslmed.abi7428 PMC 바로가기 [Article Type] Article
Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients사르데냐 다발성 경화증 환자에서 BNT162b2 백신에 대한 체액 반응에 대한 다양한 질병 수정 요법의 효과Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] Acetate addition affected age Alemtuzumab analyzed anti-SARS-CoV-2 vaccine Antibody titer Antibody titers BNT162b2 BNT162b2 vaccine Clinical data clinically COVID-19 COVID-19 vaccine demographic difference dimethyl fumarate Disease-modifying therapy drug Effect Factor fingolimod followed by fumarate Glatiramer healthy control humoral immune response Humoral immunity Humoral response immune response infected with SARS-CoV-2 interferon investigated linear Male sex mixed-effects model mRNA mRNA-based Multiple multiple sclerosis objective observé of BNT162b2 Older age Patient patients patients treated Prevent response Result Sardinian SARS-CoV-2 SARS-COV-2 infection sclerosis second dose sera serology Sex significantly significantly higher significantly lower smoking smoking status statistically significant difference Teriflunomide tested therapy Treatment treatment group treatment groups uninfected untreated patients vaccination Vaccine vaccine efficacy were assessed [DOI] 10.3389/fimmu.2021.781843 PMC 바로가기 [Article Type] Immunology