monocyte – Page 36 – Communicable Diseases Research

Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes

단핵구 감소증, 단핵구 형태 이상 및 과염증은 제2형 당뇨병에서 중증 COVID-19의 특징입니다

Observational Study

Published on 2020-09-112022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상,

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

Research Article

Published on 2020-09-032022-10-30
Journal: JCI Insight [Category] COVID-19, SARS,

[키워드] adaptive Adaptive immunity Administered Blood canonical COVID-19 COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients Critically ill cytokine Cytokine storm diagnostic dissemination Elevation ELISPOT evaluate Ex vivo functional healthy control Host host immunity host response Hyperinflammatory hypothese Hypothesis IL-6 level IL-7 immune effector cell immune function immunoassay Immunosuppression immunosuppressive innate immune Innate immunity lack less monocyte mononuclear cell morbidity and mortality organ injury pathologic Patient patients patients with COVID-19 produced proinflammatory cytokines protective immunity reduced restored Sepsis stimulated Support suppresse T cell T cell subset Therapies TNF-α Volunteer
[DOI] 10.1172/jci.insight.140329 PMC 바로가기 [Article Type] Research Article

The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)

Review

Published on 2020-09-032022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Prolonged Course of COVID-19-Associated Pneumonia in a B-Cell Depleted Patient After Rituximab

Oncology

Published on 2020-09-022022-10-31
Journal: Frontiers in Oncology [Category] COVID-19,

Special Article – Acute myocardial injury in patients hospitalized with COVID-19 infection: A review

Review article

Published on 2020-09-012022-10-05
Journal: Progress in Cardiovascular Diseases [Category] SARS, 바이오마커,

[키워드] 1 angiotensin II receptor type 1 19 Coronavirus disease 2019 ACE2 expression ACEAngiotensin Converting Enzyme ACEIAngiotensin converting enzyme inhibitor ACSAcute coronary syndrome Acute coronary syndrome Affect affected analyses angiotensin converting enzyme Angiotensin converting enzyme inhibitor angiotensin receptor blocker ARBAngiotensin receptor blocker article AT1 angiotensin II receptor type 1 Biomarker Biomarkers can be used cardiac cardiac myocytes Cardiomyopathy cardiovascular cardiovascular system clinical complex interplay COVID-19 COVID-19 virus COVID19 Coronavirus disease 2019 criteria CVcardiovascular Cytokine storm Diagnosis effective elevated Elevation endothelial injury etiology global pandemic heart failure HFheart failure hypercoagulability hyperinflammation Hypoxemia ILInterleukin incidence include Infection Inflammation interleukin Intervention lung mechanism Microvascular thrombosis MImyocardial infarction monocyte Mortality Myocardial Myocardial infarction myocardial injury myocarditis organ organ systems pathologic Patient patients patients hospitalized patients with COVID-19 potential mechanism Prevalence Protective ranged reduce Regulation Respiratory failure resulting risk risk stratification rupture SARS-CoV-2 SARSSevere Acute Respiratory Syndrome Severe acute respiratory syndrome signaling pathway ST segment elevation myocardial infarction STEMIST segment elevation myocardial infarction Stress subsequent T-cell Therapies Treatment Trial type I with COVID-19
[DOI] 10.1016/j.pcad.2020.05.013 [Article Type] Review article

Monocyte activation in systemic Covid-19 infection: Assay and rationale

Review

Published on 2020-08-302023-06-16
Journal: EBioMedicine [Category] MERS, SARS,

[키워드] Abbreviations: ace, Angiotensin converting enzyme Activation ade, Antibody dependent enhancement of infection adi, Antibody dependent enhancement of inflammation ARDS, acute respiratory distress syndrome axl, Receptor tyrosine kinase bcg, Bacille calmette guerin BMI, Body mass index COVID-19 covid-19, Coronavirus-2019 CRP, C-reactive protein CSF1R csf1r, Colony stimulating factor 1(macrophage) receptor Csf2r csf2r (gm-csf), Colony stimulating factor 2 (granulocyte macrophage) receptor CSF3R csf3r (g-csf), Colony stimulating factor 3 (granulocyte) receptor DC, dendritic cell IFN, interferon igf, Insulin-like growth factor iris, Immune reconstitution inflammation syndrome itam, Immunoreceptor tyrosine-based activation motif itim, immunoreceptor tyrosine- based inhibition motif IVIG, intravenous immunoglobulin macrophages MAS, macrophage activation syndrome MCP-1, Macrophage chemotactic protein 1 MERS, Middle East respiratory syndrome corona virus MERTK, MER proto-oncogene tyrosine kinase monocyte MPS, Mononuclear Phagocyte System NETosis, Neutrophil extracellular trap NK, natural killer cell PMN, Polymorphonuclear leukocyte SARS, Severe acute respiratory syndrome STING, stimulator of interferon genes TAM, Tumour associated macrophage TGF, Transforming growth factor TLR, Toll-like receptor TMPRSS2, transmembrane protease, serine 2 TNF, Tumor Necrosis Factor
[DOI] 10.1016/j.ebiom.2020.102964 PMC 바로가기 [Article Type] Review

The Metabolic Changes and Immune Profiles in Patients With COVID-19

Immunology

Published on 2020-08-282022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) analyzed ARDS Bacteria Bacterial infection blood glucose C-reactive protein cardiac troponin caused CD4 CD8 cells change children children with COVID-19 circulating monocyte Co-infection Comorbidity COVID-19 D-dimer decrease diabete diabetes Disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) fungi Glucose Immune profile Increased Inflammatory response Inflammatory responses interleukin-6 involved IQR lactate dehydrogenase late stage leukocytes lymphocyte metabolic metabolic disorder Metabolic disorders Mild mild COVID-19 patients MODS monocyte morbidity multiple organ dysfunction multiple organ dysfunctions (MODS) neutrophil nine Patient patients with COVID-19 procalcitonin profile RBC reduced SARS-CoV-2 serum Severe case severe COVID-19 Severe patient severe patients significantly increased susceptible syndrome T cell T cells T-lymphocytes uric acid Urine
[DOI] 10.3389/fimmu.2020.02075 PMC 바로가기 [Article Type] Immunology

Hazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: Review

Review

Published on 2020-08-132022-10-30
Journal: Journal of Medical Internet Research [Category] COVID-19, MERS,

[키워드] Activation acute respiratory syndrome Antiviral Care Case report cause caused Cohort studies Convalescent plasma therapy coronavirus coronavirus disease COVID-19 COVID-19 pandemic criteria Critically ill cytokine Cytokine storm develop disease severity early stage early treatment elevated eligible excessive cytokine response hazard Health immunology Inflammation Inflammatory cytokine Inflammatory response interferon-γ lack literature review mechanically ventilated meta-analyses monocyte morbidity and mortality Mortality mortality rate multidimensional objective pandemic Patient patients with COVID-19 positive feedback loop Protein Research Result review SARS-CoV-2 severity shown storm Support supportive care systematic reviews systemic inflammation target the cytokine storm therapy Treatment virus was performed with COVID-19
[DOI] 10.2196/20193 PMC 바로가기 [Article Type] Review

Distinguishing between COVID‐19 and influenza during the early stages by measurement of peripheral blood parameters

Research Article

Published on 2020-08-132022-11-01
Journal: Journal of medical virology [Category] COVID-19, Fulltext, MERS,

Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway

Article

Published on 2020-08-122022-10-31
Journal: Cells [Category] COVID-19,

[키워드] adipose Alter blood glucose CD11c change Chemokine receptor Complication complications condition confocal microscopy correlated Critical downstream drive ELISA expression flow cytometry fluctuation Gene Expression Glucose Glucose fluctuation glucose fluctuations glycemic control hemoglobin homeostatic hyperglycemia hypoglycemia IL-1β IL-6 independent risk factor individuals Inflammation Inflammatory Inflammatory marker Inflammatory response insulin resistance Intensive interferon regulatory factor Intermittent Involving IRF5 Macrophage macrophages marker matrix metalloproteinase mechanism metabolic inflammation monocyte monocytes/macrophages motif Necrosis occur pathway Patient patients polarization promote Protein qRT-PCR repetitive intermittent hyperglycemia response RNA siRNA T2D therapy THP-1 tissue sample TLR4 TNF-α Toll-like receptor Transcription type-2 diabete type-2 diabetes western blotting
[DOI] 10.3390/cells9081892 PMC 바로가기 [Article Type] Article