Neutralizing activity – Page 36 – Communicable Diseases Research

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

SARS-CoV-2 스파이크에서 우성 및 하위 우성 에피토프를 인식하는 단일클론 항체의 중화 효능은 B.1.1.7 변이체의 영향을 받습니다.

Article

Published on 2021-06-082022-09-10
Journal: Immunity [Category] MERS, SARS, 변종, 진단,

Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain

급성 SARS-CoV-2 감염에 대한 세포 및 혈청학적 반응 평가는 수용체 결합 도메인의 기능적 중요성을 보여줍니다

Article

Published on 2021-06-012022-09-11
Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 치료법,

Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes

회복기 혈청 및 백신 유도 항체는 글로벌 SARS-CoV-2 변이체 스파이크에 대한 중화 역가를 크게 유지합니다

Research Article

Published on 2021-06-012022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

[키워드] 20A.EU2 a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody B.1.1.248 B.1.1.7 B.1.351 BNT162b2 Cluster cocktail COH.20G/677H coronavirus decrease E484K effective elicited less maintain mink cluster 5 minor monoclonal antibody monoclonal antibody therapy Mutation natural infection neutralization neutralize neutralized Neutralizing activity Patient Pfizer Pfizer BNT162b2 Prevalence Pseudotyped virus Pseudotyped viruses raise Regeneron REGN10933 REGN10987 respiratory SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus spike Spike protein Spike proteins therapeutic therapy titer vaccination Vaccine variant variants viruses
[DOI] 10.1128/mBio.00696-21 PMC 바로가기 [Article Type] Research Article

Antibody Responses One Year after Mild SARS-CoV-2 Infection

가벼운 SARS-CoV-2 감염 1년 후 항체 반응

Article

Published on 2021-05-312022-09-11
Journal: Journal of Korean medical science [Category] SARS, 진단, 치료기술,

Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2

SARS-CoV-2의 Spike-RBD에 특이적인 새로운 인간 중화 mAb

Article

Published on 2021-05-262022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 진단,

[키워드] ACE2 ACE2 receptor Anti-spike anti-spike MAbs antibody binding domain Biotechnology candidate Cell Cell culture cell cultures cell entry contagious Diseases Drug discovery epitope expressed function glycoprotein identify IgG1 IgG4 immune system Interaction interfere Isolation mAb mAbs monoclonal monoclonal antibodies mutations Neutralizing Neutralizing activity novel pandemic Protein purified RBD receptor recognizing SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 virus scFv Side effect spike spike glycoprotein the SARS-CoV-2 virus the Spike therapeutic therapy variant virus virus entry virus infection VOC 202012/01
[DOI] 10.1038/s41598-021-90348-7 PMC 바로가기 [Article Type] Article

Anti-SARS-CoV-2 Antibodies Testing in Recipients of COVID-19 Vaccination: Why, When, and How?

Opinion

Published on 2021-05-252022-10-31
Journal: Diagnostics [Category] COVID-19,

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines

비활성화 및 RBD-서브유닛 백신에 의해 유발된 순환 SARS-CoV-2 변이체에 대한 체액 면역 반응

Article

Published on 2021-05-212022-09-11
Journal: Cell Research [Category] Fulltext, SARS, 변종, 진단,

[키워드] (inactivated vaccine) 501Y.V2 administration anti-RBD antibody antigenic B.1.351 boost caused circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants combating Combination comparable conformation Contact convalescent CoronaVac Cryoelectron microscopy disrupt dominant E484K Effect elicited humoral immune response Immune escape immune response immunology inactivated Inactivated vaccine induce K417N leads less majority mononuclear cell mononuclear cells Mutation mutations N-terminal domain NAb NAbs natural infection neutralization neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody NTD Peripheral blood Peripheral blood mononuclear cells plasma polar RBD RBD variants receptor Receptor-binding domain reduced reduction regions respond SARS-CoV-2 variant SARS-CoV-2 variants second dose Sequencing single-cell the receptor-binding domain Tolerance Vaccine vaccinee vaccinees variants VDJ X-ray crystallography ZF2001
[DOI] 10.1038/s41422-021-00514-9 PMC 바로가기 [Article Type] Article

Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational study

COVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 반응의 역학: 관찰 연구

Clinical Trial

Published on 2021-05-182022-09-12
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 진단, 치료기술,

[키워드] age albumin antibody-based therapy caution China Cohort correlated COVID-19 COVID-19 patient decay declined Dilution disease severity Dynamics enrolled feasibility FRNT half-time infected individual Infection Infectious diseases median time Mild NAb NAbs neutralization neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response observation onset of symptoms Patient peaked positive positively correlated protective immunity reached remained SARS-CoV-2 Seroconversion serum albumin severity of COVID-19 surrogate virus neutralization test sVNT Vaccine validation study virus neutralization test
[DOI] 10.1038/s41392-021-00611-6 PMC 바로가기 [Article Type] Clinical Trial

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

LIBRA-seq를 통한 회복기 COVID-19 환자의 SARS-CoV-2 특이적 기억 B 세포의 신속한 분리 및 면역 프로파일링

Article

Published on 2021-05-172022-09-12
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단,

[키워드] activated Adaptive immunity analyzed antibody Antigen B cell response BCR binding affinity CD11c Cell convalescent COVID-19 patient convalescent COVID-19 patients convalescent individuals Critical Diversity domain ELISA assay exhibited FIVE Frequency heterogeneity immune profiling immune responses Immunoglobulin in vitro Infectious diseases Isolation memory memory B memory B cell memory B cells Neutralizing activity nucleoprotein performed plasma B cell plasma B cells proportion provide pseudotyped Rapid RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 virus Sequencing single-cell level Single-cell RNA sequencing specificity Spectrum transcriptional VDJ Via
[DOI] 10.1038/s41392-021-00610-7 PMC 바로가기 [Article Type] Article

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다

Research Article

Published on 2021-05-122022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread
[DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article