Field Evaluation of the New Rapid NG-Test ® SARS-CoV-2 Ag for Diagnosis of COVID-19 in the Emergency Department of an Academic Referral Hospital학술 추천 병원 응급실에서 COVID-19 진단을 위한 새로운 Rapid NG-Test ® SARS-CoV-2 Ag의 현장 평가Article Published on 2022-04-252022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute infection affecting ambulatory patient analyzed Antigen antigen test COVID-19 COVID-19 pandemic Department determine Diagnosis diagnostic diagnostics Emergency emergency department evaluate field Greece high viral load hospital immunoassay lateral flow lateral flow immunoassay nasopharyngeal New NG-Test® SARS-CoV-2 Ag NP swab NP swabs NPV numbers of patients Oropharyngeal Patient PCR testing per day point-of-care point-of-care test point-of-care tests positive PPV Predictive presenting qualitative detection Rapid rapid diagnostics Referral RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 PCR testing sensitivity specificity swabs tested university Viral load viral loads [DOI] 10.3389/fpubh.2022.840984 PMC 바로가기 [Article Type] Article
Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA)Research article Published on 2022-04-212022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] 28-day mortality 95% CI anti-SARS-CoV-2 antibody antibody Antibody Response assessment assigned authority benefit clearance combination therapy Coronavirus disease 2019 Coronavirus disease-19 COVACTA COVID-19 Department development died discharged double-blind Effect Efficacy and safety Europe finding funding Future Hoffmann-La Roche hospital hospital discharge hospitalised Host immune response Human impair IMPROVE Infection intensive care interleukin-6 intravenous tocilizumab investigated Mortality Nasopharyngeal swab neutralising North America occurred office other treatments Patient patient selection patients with COVID-19 Placebo placebo-controlled trial polymerase chain positive test result Potential biomarker randomised randomised controlled trial Randomly respiratory response SARS-CoV-2 SARS-CoV-2 viral load Secretary serum serum samples severe acute respiratory syndrome coronavirus-2 tested Tocilizumab Treatment viral clearance Viral load with COVID-19 [DOI] 10.1016/j.eclinm.2022.101409 [Article Type] Research article
Recent advances in passive immunotherapies for COVID-19: The Evidence-Based approaches and clinical trialsReview Published on 2022-04-212022-10-04 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 임상, 치료제, [키워드] 2019-nCoV, 2019 novel coronavirus Abstract accompany ACE-2, Angiotensin-Converting Enzyme-2 acute respiratory disease syndrome acute respiratory distress acute respiratory syndrome ADE, Antibody-dependent enhancement adverse effect AE(s), Adverse effect(s) AEs approach ARDS ARDS, acute respiratory distress syndrome CAR, Chimeric antigen receptor Cellular Immunotherapy clinical trial Community complementary Convalescent plasma (CP) therapy coronavirus COVID-19 COVID-19 vaccination COVID-19 vaccines COVID-19, Coronavirus disease 2019 CPT, Convalescent plasma therapy CRP, C-reactive protein CRS, Cytokine release syndrome CT(s), Clinical trial(s) Cytokine storm Efficacy effort emerging disease epidemiological ESR, Erythrocyte sedimentation rate FCR, Fc receptor FDA, Food and Drug Administration global pandemic GM-CSF, granulocyte-macrophage colony-stimulating factor group GVHD, Graft-versus-host disease HBV, Hepatitis B HCV, Hepatitis C highlight HIV, Human immunodeficiency virus HLH, Hemophagocytic lymphohistiocytosis Human I.V., Intravenous IBD, Inflammatory bowel disease IFN, interferon IGG, immunoglobulin g immunomodulation Immunotherapy Inflammation inhibiting International investigated IVIG, intravenous immunoglobulin LAG-3, Lymphocyte-activation gene 3 LDH, lactate dehydrogenase mAb(s), Monoclonal antibody(s) MERS-COV, Middle East respiratory syndrome-corona virus monoclonal antibody MV, Mechanical ventilation Passive Passive immunotherapy PCR, polymerase chain reaction PD-1, Programmed cell death protein-1 platform RA, Rheumatoid arthritis RBD, receptor-binding domain recent reduced SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 syndrome TIM-3, T cell immunoglobulin domain and mucin domain-3 TNF, Tumor Necrosis Factor TRALI, Transfusion-related acute lung injury treating COVID-19 patient Treatment Vaccine variants of SARS-CoV-2 VEGF, Vascular endothelial growth factor Viral load viral neutralization [DOI] 10.1016/j.intimp.2022.108786 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 Omicron Variant Does Not Have Higher Nasal Viral Loads Compared to the Delta Variant in Symptomatic and Asymptomatic IndividualsSARS-CoV-2 오미크론 변종은 증상 및 무증상 개인에서 델타 변종에 비해 비강 바이러스 부하가 더 높지 않습니다Article Published on 2022-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] Abstract Alpha anterior nares BA.1 Delta individual load nasal omicron SARS-CoV-2 variants Viral load [DOI] 10.1128/jcm.00139-22 PMC 바로가기 [Article Type] Article
Highly Sensitive Lineage Discrimination of SARS-CoV-2 Variants through Allele-Specific Probe PCR대립유전자 특이적 프로브 PCR을 통한 SARS-CoV-2 변이체의 고감도 계통 판별Article Published on 2022-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] adopted allele allele-specific probe PCR alternative method alternative methods Brazil clinical trial cohorts Comparative advantage COVID-19 therapeutics cycle threshold Degradation detect diagnostics discrimination effort Evidence evidence of Evolution Future future work gold gold standard high accuracy identify individual likelihood lineages Next-generation sequencing NGS nucleotide PCR probe public health Regression model required Result RNA SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants screened sensitive shown Single nucleotide polymorphism SNP SNPs Support United Kingdom Vaccines variant Variant identification variants variants of concern Viral load viral loads virus [DOI] 10.1128/jcm.02283-21 PMC 바로가기 [Article Type] Article
Emulation of a Target Trial From Observational Data to Compare Effectiveness of Casirivimab/Imdevimab and Bamlanivimab/Etesevimab for Early Treatment of Non-Hospitalized Patients With COVID-19COVID-19로 입원하지 않은 환자의 조기 치료를 위한 Casirivimab/Imdevimab 및 Bamlanivimab/Etesevimab의 효과를 비교하기 위한 관찰 데이터의 표적 시험 에뮬레이션Clinical Trial Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adjusted allocation Alpha Analysis ANCOVA bamlanivimab bamlanivimab/etesevimab baseline carried Casirivimab casirivimab/imdevimab Combination Comparative analysis COVID-19 Cox model Ct value cycle threshold death Delta determine early treatment early treatment for COVID-19 Effectiveness enrolment etesevimab evaluated Evidence Factor Factors high viral load Hospitalization Imdevimab in viral Intervention Logistic regression mAb mAbs Mild-to-moderate Model Modification monoclonal antibodies monoclonal antibody Nasopharyngeal swab negative RT-PCR not used Observational data occurred outcome Outpatient outpatients Patient PCR test Primary outcome Probability progression reduced risk reduction Relative risk risk reduction RT-PCR test SARS-CoV-2 Stratification subject target Treatment Trial two group two groups vaccination variants variants of concern Viral Viral load viral load reduction virological response VOCs was measured was used were used [DOI] 10.3389/fimmu.2022.868020 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected [DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article
[Effects of hepatitis B virus on Th17, Treg and Th17/Treg ratio in different alanine aminetransferase stages]Article Published on 2022-04-182023-06-12 Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe [Category] B형 간염, [키워드] Chronic Hepatitis B Th17 cells Treg cells Viral load [DOI] 10.19723/j.issn.1671-167X.2022.02.012 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant StrainsReview Published on 2022-04-162023-07-01 Journal: Viruses [Category] COVID19(2023년), SARS, [키워드] SARS-CoV-2 variants sensitivity to antisera Transmissibility Viral load [DOI] 10.3390/v14040827 PMC 바로가기 [Article Type] Review
Link between SARS-CoV-2 emissions and airborne concentrations: Closing the gap in understandingSARS-CoV-2 배출과 공기 중 농도 간의 연결: 이해의 격차 해소Article Published on 2022-04-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 치료기술, [키워드] Airborne SARS-CoV-2 concentration Airborne virus transmission Analysis approach Comparative analysis Concentration conducted COVID-19 emission Evidence Health hospital Metrological compatibility analysis. Nasopharyngeal swab Predictive provided regulatory authority Result resulting RNA copies RNA copy room SARS-CoV-2 shown subject the SARS-CoV-2 threshold Transmission transmission of SARS-CoV-2 Viral load virus [DOI] 10.1016/j.jhazmat.2022.128279 PMC 바로가기 [Article Type] Article