Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike VariantD614G 스파이크 변이체 출현 후 SARS-CoV-2에 대한 결합된 현장 진료 핵산 및 항체 테스트Report Published on 2020-09-012022-09-10 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% CI Accuracy acid amplification anti-spike antibodies anti-spike antibody antibody Antibody test antibody tests Blood Combined CoV COVID-19 COVID-19 diagnosis COVID-19 disease cross-react D614G detect detection rate diagnose diagnosis of COVID-19 diagnostic Diagnostic accuracy emergence False positivity Finger prick hospital immune response immune responses IMPROVE mutant Mutant SARS-CoV-2 NAAT nose/throat swab not affected nucleic acid nucleic acid amplification nucleic acid amplification testing Nucleic acid detection pandemic POC point of care point of care testing Rapid Rapid antibody tests rapid diagnoses report SARS-CoV-2 SARS-CoV-2 antibody test SARS-CoV-2 nucleic acid sensitivity serological test Serological tests specificity spike Spike D614G variant Testing the SARS-CoV-2 variant wild-type [DOI] 10.1016/j.xcrm.2020.100099 PMC 바로가기 [Article Type] Report
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwideArticle Published on 2020-08-202022-10-04 Journal: Scientific Reports [Category] MERS, 변종, [키워드] Analysis applied association bioinformatics caused clade Clinical outcome coronavirus 2 COVID-19 case COVID-19 pandemic D614G deaths diagnosed disease severity Epidemiology Europe Evolution Evolutionary genetics Future genomic human ACE2 receptor Infectious diseases Interaction Johns Hopkins lack Metadata Microbial genetics Missense mutation MONITOR Mutation Neutral pandemic performed phenotype Phylogenetic analysis predominant prevented Protein respiratory SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 genome SARS-CoV-2 strain sequenced Spike protein the spike protein viral clade virulence virus World Health Organization [DOI] 10.1038/s41598-020-70827-z PMC 바로가기 [Article Type] Article
Comprehensive Analyses of SARS-CoV-2 Transmission in a Public Health Virology LaboratoryArticle Published on 2020-08-052022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] 2019-nCoV affecting Analysis association asymptomatic infection clade Cluster Comprehensive contaminated surface COVID-19 D614G event events exhibited healthcare IgA antibody IgG Inclusion infected individual Infection Laboratory mandatory Molecular epidemiology Mutation next generation sequencing (NGS) Occurrence outbreak pandemic PCR polymerase chain Public real time Retrospective study SARS-CoV-2 SARS-CoV-2 genome sequenced serology test social distancing spike mutation Spread staff suspicion Transmission Virology virus spread were infected [DOI] 10.3390/v12080854 PMC 바로가기 [Article Type] Article
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains UnclearArticle Published on 2020-07-032022-10-05 Journal: Cell [Category] SARS, 변종, [키워드] change COVID-19 D614G disease dominant in vitro data Making Mutation phenotype SARS-CoV-2 variant sense the spike protein therapeutic Transmission Vaccine virus [DOI] 10.1016/j.cell.2020.06.040 [Article Type] Article
Variant analysis of SARS-CoV-2 genomesResearch Published on 2020-07-012022-10-27 Journal: Bulletin of the World Health Organization [Category] COVID-19, [키워드] acute respiratory syndrome amino acid residues Analysis Bayesian changes clade clades coding region Coronavirus-2 D614G Deletion deletions downloaded finding Frame frameshift Genome genome variant genome variants identified variant indicated infected patient insertions Missense mutations Mutation mutations NC_045512 non-coding regions objective reference genome SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome several variant stop-gained subclades synonymous the SARS-CoV-2 genome the spike protein Transmission variant variants [DOI] 10.2471/BLT.20.253591 PMC 바로가기 [Article Type] Research
Variant analysis of SARS-CoV-2 genomesResearch Published on 2020-07-012022-10-27 Journal: Bulletin of the World Health Organization [Category] Coronavirus, COVID-19, SARS, [키워드] acute respiratory syndrome amino acid residues Analysis Bayesian changes clade clades coding region Coronavirus-2 D614G Deletion deletions downloaded finding Frame frameshift Genome genome variant genome variants identified variant indicated infected patient insertions Missense mutations Mutation mutations NC_045512 non-coding regions objective reference genome SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome several variant stop-gained subclades synonymous the SARS-CoV-2 genome the spike protein Transmission variant variants [DOI] 10.2471/BLT.20.253591 PMC 바로가기 [Article Type] Research
Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?Short communication Published on 2020-07-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 유전자 메커니즘, [키워드] clade clinical outcomes Community coronavirus country COVID-19 COVID-19 pandemic current D614G D614G substitution death death rate explain fatality Fatality rate Genetic Increased intensive care International lower mortality Mutation Phylogenetic Protein raised Research responsible S-protein SARS-CoV-2 the SARS-CoV-2 [DOI] 10.1016/j.ijid.2020.05.071 [Article Type] Short communication
A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?Brief Report Published on 2020-05-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] analyzed antigenic antigenicity B-cell epitope Characteristics coronavirus COVID-19 D614G effective evade Evolution of SARS-CoV-2 exhibited host immune system Mutation novel Pathogenesis Phylogenetic analysis Prevent reduced required S gene S glycoprotein S1 domain SARS-CoV-2 SARS-CoV-2 strains sequence serological Spike protein strain subtype Subtypes synonymous Vaccine viral entry virus [DOI] 10.3390/vaccines8020220 PMC 바로가기 [Article Type] Brief Report