A review on drug repurposing applicable to COVID-19COVID-19에 적용 가능한 약물 용도 변경 검토Review Published on 2021-03-222022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, 치료제, [키워드] AI applied approach approaches artificial intelligence chemical compound chemical compounds Clustering Compound Computational drug coronavirus disease Coronavirus disease 2019 COVID-19 drug Drug repurposing drug-target drugs evaluate identify less macromolecular molecular molecular docking moment network-based approaches new therapies. pandemic Protein target Therapies with COVID-19 [DOI] 10.1093/bib/bbaa288 PMC 바로가기 [Article Type] Review
A review of COVID-19 biomarkers and drug targets: resources and toolsCOVID-19 바이오마커 및 약물 표적에 대한 검토: 리소스 및 도구Review Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, 신약개발, 치료제, [키워드] Analysis artificial intelligence bioinformatics Biomarker Biomarkers Community computational method Computational methods corpus COVID-19 disease Drug repurposing drug target example extreme identify knowledge machine learning molecular outbreak pandemic Patient progression resource risk selected starting Stratification therapeutic options therapeutic target Treatment Vaccine development [DOI] 10.1093/bib/bbaa328 PMC 바로가기 [Article Type] Review
Drug repurposing for COVID-19: could vitamin C combined with glycyrrhizic acid be at play by the findings of Li et al.’s database-based network pharmacology analysis?COVID-19에 대한 약물 용도 변경: Li et al.의 데이터베이스 기반 네트워크 약리학 분석 결과에서 글리시리진산과 결합된 비타민 C가 작용할 수 있습니까?Article Published on 2021-03-222022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, [키워드] caused coronavirus disease Coronavirus disease 2019 COVID-19 Critical drug Drug repurposing Evidence global health glycyrrhizic acid Health Hypothesis involved limitation network pharmacology outbreak pandemic paper Perspective public health SARS-CoV-2 treating COVID-19 Vitamin C was performed [DOI] 10.1093/bib/bbaa330 PMC 바로가기 [Article Type] Article
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trialCOVID-19에 대한 이트라코나졸: 전임상 연구 및 개념 증명 무작위 임상 시험Randomized Controlled Trial Published on 2021-03-192022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 비임상, 신약개발, 임상, 진단, 치료제, [키워드] 7-point ordinal scale 95% CI absence acute infection acute SARS-CoV-2 infection adequate plasma antifungal drug itraconazole antivirals assigned breath Caco-2 clinical status Clinical studies clinical study clinical trial COVID-19 cumulative score did not reduce drug concentrations Drug repurposing effective evaluated finding foundation funding geometric Geometric means Health Organization Horizon hospitalized COVID-19 patient hospitalized COVID-19 patients human Caco-2 cells ileum in vitro activity initial interim analysis itraconazole Leuven lung Lungs Melinda Gate Melinda Gates not effective Open-label Ordinal Scale outcome Preclinical preclinical studies preclinical study premature termination Prevent prevention of COVID-19 Primary outcome proof-of-concept clinical study randomized clinical trial Randomly required SARS-CoV-2 SARS-COV-2 infection showed no signal single-center study Standard of care Stool stools Transmission Transmission model Treatment Vero Viral Viral load viral load in lungs Viral transmission World Health Organization [DOI] 10.1016/j.ebiom.2021.103288 PMC 바로가기 [Article Type] Randomized Controlled Trial
Expanding Our Understanding of COVID-19 from Biomedical Literature Using Word EmbeddingArticle Published on 2021-03-152022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 신약개발, [키워드] accumulated anti-infective drug articles Characteristics Clinical characteristics coronavirus coronavirus disease COVID-19 Drug repurposing embedding Health information knowledge literature machine learning Medical Subject Headings Numerous overcome Protein PubMed literature required Research researcher substance name treatments for COVID-19 understanding Vaccine word embedding [DOI] 10.3390/ijerph18063005 PMC 바로가기 [Article Type] Article
Artificial Intelligence–Aided Precision Medicine for COVID-19: Strategic Areas of Research and DevelopmentCOVID-19를 위한 인공 지능 지원 정밀 의학: 연구 및 개발의 전략적 영역Viewpoint Published on 2021-03-122022-09-10 Journal: Journal of Medical Internet Research [Category] SARS, 신약개발, 치료기술, [키워드] Area artificial artificial intelligence Care COVID-19 COVID-19 pandemic development Diagnosis Drug repurposing Epidemic Epidemics Health Health care highlight IMPROVE literature Medicine monitoring outbreak outcomes pandemic Patient Personalized medicine pharmacogenomics precision medicine prevention public health public health system public health systems risk SARS-CoV-2 Triage [DOI] 10.2196/22453 PMC 바로가기 [Article Type] Viewpoint
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug RepurposingPharmacology Published on 2021-03-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral effect approach Artemisinin benefit candidate clinical trial Concentration coronavirus disease COVID-19 Diagnosis disease modeling dosing regimen dropped drug drug candidate Drug repurposing Effect effective explained Host host response human SARS-CoV-2 Hydroxychloroquine immune response in vitro in vitro experiment in vivo Informed Intervention Ivermectin log lung tissue modeling Pharmacometrics profile reduce Repurposed drug repurposing SARS-CoV-2 selected Treatment viral dynamics viral kinetics Viral load were given [DOI] 10.3389/fphar.2021.625678 PMC 바로가기 [Article Type] Pharmacology
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variantsSARS-CoV-2 치료 표적 및 비동의어 변이체에 초점을 맞춘 DockThor-VS 웹 서버를 통한 약물 설계 및 용도 변경Article Published on 2021-03-102022-08-31 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 치료제, [키워드] (RdRp) 3CLpro 3D structure caused Computational platforms and environments COVID-19 curated disease docking domain drug Drug repurposing effective experiment facilitate FDA-approved drug FDA-approved drugs genetic information Health Organization High-throughput screening identify market methodology MPro Mutation N protein Non-synonymous Nsp12 Nsp15 Nsp3 nsp5 pandemic disease Papain performed platform PLPro potential therapeutic target potential therapeutic targets present provide RdRP SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 virus selected spike Structure Structure-based drug design the SARS-CoV-2 virus therapeutic target therapeutic targets Treatment variant variations Virtual drug screening Virtual screening web server WHO wild type World Health Organization [DOI] 10.1038/s41598-021-84700-0 PMC 바로가기 [Article Type] Article
An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?Pharmacology Published on 2021-03-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affecting Against Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antibiotics antiviral drugs antivirals approach approved drug Candidates Chloroquine Clinical efficacy Clinical findings clinical study clinical trial clinically Complete conducted Convalescent plasma therapy Corticosteroid COVID-19 COVID-19 pandemic COVID-19 patients drug Drug repurposing Drug-drug interactions drugs effective Effectiveness evaluate Favipiravir Hydroxychloroquine identify International limitation Long-term follow-up Lopinavir-ritonavir Lung inflammation mechanism mechanism of action Open-label oseltamivir pharmacokinetics Placebo Population Randomized randomized clinical trial recorded reduce regimens regions Registered Remdesivir Repurposed drug Research ribavirin SARS-CoV-2 Spread therapeutic Till treat Treatment Trial umifenovir virus were used WHO [DOI] 10.3389/fphar.2021.632677 PMC 바로가기 [Article Type] Pharmacology
The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2Bromelain과 Acetylcysteine(BromAc)의 조합은 SARS-CoV-2를 상승적으로 비활성화합니다Article Published on 2021-03-062022-09-10 Journal: Viruses [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 receptor Acetylcysteine acute respiratory syndrome acute respiratory syndrome coronavirus administration binding breakage BromAc Bromelain clinical clinical testing coronavirus Culture demonstrated determine Disulfide disulfide bond Drug repurposing envelope protein envelope proteins glycoprotein Glycoproteins glycosidic host cell host cells in vitro inactivation Infection nasal nasal mucosa Patient recombinant reduce reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus spike spike glycoprotein spike mutants synergistic synergistic action therapeutic options Treatment virus virus culture wild-type worldwide pandemic [DOI] 10.3390/v13030425 PMC 바로가기 [Article Type] Article