Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adultsArticle Published on 2022-08-012023-07-09 Journal: Journal of internal medicine [Category] COVID19(2023년), [키워드] Breakthrough infection COVID-19 Hospitalization Mortality vaccination [DOI] 10.1111/joim.13504 PMC 바로가기
Outcomes of bebtelovimab and sotrovimab treatment of solid organ transplant recipients with mild-to-moderate coronavirus disease 2019 during the Omicron epoch2019년 오미크론 시대 동안 경증에서 중등도의 코로나바이러스 질환이 있는 고형장기이식 환자의 베텔로비맙 및 소트로비맙 치료 결과Article Published on 2022-08-012022-09-12 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Admission analyzed Anti-spike anti-spike monoclonal antibody appear bebtelovimab booster Clinical data conducted confounders coronavirus coronavirus disease COVID-19 COVID-19 diagnosis diagnosed dose Effectiveness Emergency use authorization Fisher group Hospitalization Hospitalized individual intensive care kidney Mild-to-moderate monoclonal monoclonal antibody omicron organ Organ transplant organ transplantation Patient patients died Prevent Primary outcome proportion recipient required retrospective cohort study SARS-CoV-2 SARS-CoV-2 vaccine Severe infection solid organ solid organ transplant Treatment vaccination vaccination rate while [DOI] 10.1111/tid.13901 PMC 바로가기 [Article Type] Article
Limb ischemia due to spontaneous heparin-induced thrombocytopenia as the primary presentation of acute COVID-19 infection급성 COVID-19 감염의 주요 증상인 자발적 헤파린 유발 혈소판 감소증으로 인한 사지 허혈Case Reports Published on 2022-08-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 진단, [키워드] 2019 coronavirus disease absence activate acute COVID-19 addition administration antibodies characterized complexes COVID-19 develop enzyme-linked immunosorbent had no heparin Hospitalization IgG antibody immunoglobulins, intravenous Infection instances Intravenous immunoglobulin Ischemia less male occur Pain Patient PF4 Platelet platelet activation positive presenting prothrombotic condition reported Serotonin Spontaneous spontaneous heparin-induced thrombocytopenia SRA syndrome thrombocytopenia thrombosis treated Vaccinations [DOI] 10.1007/s11239-022-02676-8 PMC 바로가기 [Article Type] Case Reports
Evaluation of individual and combined NLR, LMR and CLR ratio for prognosis disease severity and outcomes in patients with COVID-19COVID-19 환자의 질병 중증도 및 결과에 대한 개별 및 결합된 NLR, LMR 및 CLR 비율 평가Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] 바이오마커, 진단, 치료기술, [키워드] Analysis C-reactive protein characterized CLR Combination Combined Combined markers COVID-19 COVID-19 cases COVID-19 disease COVID-19 patients Critically ill Deceased develop disease disease severity Efficacy healthy controls healthy subject healthy subjects Hospital admission Hospitalization ICU ill patient immunological parameter IMPROVE independent Inflammatory intensive care unit lymphocyte marker material Mild moderate Mortality multivariate logistic regression multivariate logistic regression analysis neutrophil neutrophil/lymphocyte ratio NLR non-ICU normal value outcome parameter pathology Patient patients with COVID-19 performed Peripheral blood Predictive Prognosis Prognostic factor Prominent resulting returned ROC SARS-CoV-2 severe disease Severe infection severity of COVID-19 [DOI] 10.1016/j.intimp.2022.108781 PMC 바로가기 [Article Type] Article
Early remdesivir to prevent severe COVID-19 in recipients of solid organ transplant: a real-life study from Northern ItalyObservational Study Published on 2022-08-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 3-day course remdesivir cohort of patient conducted confidence interval Course COVID-19 effective Effectiveness Efficacy hazard ratio Hospitalization Hospitalized hospitalized patient infected with SARS-CoV-2 Italy Matteo organ Outpatient P-value Patient patients with COVID-19 Pavia Prevent receive receiving recipient recipients reduced reducing Remdesivir retrospective Seven severe COVID-19 severe disease significantly single-center solid organ solid organ transplant Solid organ transplant recipients SOT therapeutic option worsening [DOI] 10.1016/j.ijid.2022.05.001 PMC 바로가기 [Article Type] Observational Study
Severity and mortality of COVID-19 in patients with systemic sclerosis: a Brazilian multicenter studyObservational Study Published on 2022-08-012022-10-05 Journal: Seminars in arthritis and rheumatism [Category] 임상, [키워드] 95% CI age Analysis Cohort cohort of patient Comorbidity cough COVID-19 COVID-19 in patient death deaths diagnosed with COVID-19 disease Dyspnea evaluate FVC Gender greater higher risk highly suspicious infection Hospitalization impacted Infection Interstitial lung disease lung Lung disease Mild moderate-to-severe COVID-19 Mortality multicenter need for oxygen outcome Patient patients patients with COVID-19 positive RT-PCR predictor presenting Prevalence pulmonary arterial hypertension remained retrospective severity significantly Support Symptom systemic Systemic sclerosis the patient Treatment Univariate analysis use of corticosteroids [DOI] 10.1016/j.semarthrit.2022.151987 PMC 바로가기 [Article Type] Observational Study
Robust humoral and cellular immune responses in long-term convalescent COVID-19 individuals following one-dose SARS-CoV-2 inactivated vaccinationSARS-CoV-2 비활성화 백신 접종 후 장기간 회복 중인 COVID-19 개인의 강력한 체액 및 세포 면역 반응Article Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] addition anti-S Antigen antigen-specific T cell Antigen-specific T cells B cell booster caused CD4 Cellular immune response characterized convalescent COVID-19 death demonstrated Efficacy exhibited frequencies Frequency healthy healthy individual healthy individuals Hospitalization humoral IFN-γ IgG IL-2 immune immune responses inactivated Inactivated vaccine individual infected patient Infection long-term convalescent. NAbs Neutralizing antibodies neutralizing antibody neutralizing capacity RBD IgG RBD-specific IgG recipients recovered patient recovered patients robust SARS-CoV-2 SARS-CoV-2 inactivated vaccine SARS-CoV-2 RBD SARS-CoV-2 vaccine severe disease significantly significantly higher significantly increased single dose subject T cell T cell response T cell responses T cells the vaccine TNF-α utility vaccination Vaccine vaccine-induced immune response variants variants of concern VoC VOCs wild type [DOI] 10.3389/fimmu.2022.966098 PMC 바로가기 [Article Type] Article
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestriesOAS1 넌센스 매개 부패의 유전적 조절은 유럽 및 아프리카 혈통의 환자에서 COVID-19 입원과의 연관성을 뒷받침합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African allele Analysis Antiviral association Bioinformatic clearance clinical trial contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity decrease disease early treatment European exonic expression functional Genetic genetic regulation Haplotype Hospitalization Hospitalized in vitro study interferon interferons locus mitigate molecular mechanism molecular mechanisms OAS1 Patient Protein reduced Regulation risk SARS-CoV-2 SARS-CoV-2 clearance severe COVID-19 splicing susceptibility variant with COVID-19 [DOI] 10.1038/s41588-022-01113-z PMC 바로가기 [Article Type] Article
Imbalance between alpha-1-antitrypsin and interleukin 6 is associated with in-hospital mortality and thrombosis during COVID-19Short communication Published on 2022-08-012022-10-05 Journal: Biochimie [Category] 바이오마커, 치료기술, [키워드] 95%CI adjusted Admission age alpha-1-antitrypsin Anti-inflammatory Anticoagulant BMI COVID-19 COVID-19 severity Critically ill cross-sectional D-dimer levels examined hallmark Hospitalization hospitalized patient IL-6 Imbalance in-hospital mortality Inflammation intensity involved Logistic regression marker mechanism Mortality multivariable analysis non-survivor Occurrence offer pathophysiology Patient patients performed phenotyped plasma predict Predictive proportion Protective protective factor Restoring severe COVID-19 severity Sex subset suffered survivor therapeutic thrombosis tissue variant with COVID-19 [DOI] 10.1016/j.biochi.2022.07.012 [Article Type] Short communication
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials심혈관계 약물 및 코로나19 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-08-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval Accuracy ACEi ACEIs amlodipine angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Anticoagulants anticoagulation antiplatelet approved ARBs Aspirin atorvastatin baseline blocker calcium calcium channel calcium channel blockers cardiovascular cardiovascular drugs Clinical outcome Completeness COVID-19 COVID-19 severity database drug Evidence had no Hospitalization identify initiated investigated Living systematic review mean difference meta-analyses Meta-analysis moderate Mortality no effect not affect observational studies observational study Other outcomes Prevent Quantitative Randomized controlled trial RCT RCTs receptor receptor blocker reported risk risk ratio searched severity sulodexide systematic review therapeutic therapeutic anticoagulation treat Trial trials [DOI] 10.1111/bcp.15331 PMC 바로가기 [Article Type] Review