Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodySpike S2 도메인 특이적 인간 중화 단일클론 항체의 직접적인 호흡기 투여에 의해 매개되는 강력한 보편적인 베타-코로나바이러스 치료 활성Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta acute respiratory syndrome acute respiratory syndrome coronavirus-2 Administered administration antibody Beta beta-coronavirus check conserved convalescent coronavirus coronavirus vaccine Delta demonstrated determine dose Epsilon Gamma hACE2 hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IgG Immune escape in vivo infected with SARS-CoV-2 Infection infection with SARS-CoV-2 intranasal K18 Lineage mAb mAbs MERS-CoV mice monoclonal antibody Mortality Mutation neutralize SARS-CoV neutralized Neutralizing omicron plasma potent pre-fusion Prevent Prophylactic Recognition recognize reduced respiratory respiratory viral S1 and S2 S2 domain SARS-CoV Urbani SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 significantly spike subject subjects tested therapeutic activity therapeutic potential Vaccine variants of concern Viral virus weight loss β-coronavirus [DOI] 10.1371/journal.ppat.1010691 PMC 바로가기 [Article Type] Article
Evidence of Maternal Antibodies Elicited by COVID-19 Vaccination in Amniotic Fluid: Report of Two Cases in Italy양수에서 COVID-19 백신 접종으로 유도된 모체 항체의 증거: 이탈리아의 2건의 사례 보고Case Reports Published on 2022-07-212022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] administration amniotic Amniotic fluid Antenatal anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibodies antibody Birth center collected COVID-19 COVID-19 vaccination Critical cross Efficiency elicited evidence of fetus gestation high risk highlighting IgG immunization Infant Infants Infectious disease Infectious diseases Italy Kinetics Maternal mechanism Newborn offer outcomes passive immunity persistence Placenta Pregnancy pregnant women prevention regimens report response to vaccination SARS-COV-2 infection second dose serum severe disease tested titer titers transfer vaccination women [DOI] 10.3390/v14071592 PMC 바로가기 [Article Type] Case Reports
Kinetics of anti-nucleocapsid IgG response in COVID-19 immunocompetent convalescent patientsCOVID-19 면역적격 회복기 환자에서 항뉴클레오캡시드 IgG 반응의 동역학Article Published on 2022-07-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] absence anti-Nucleocapsid IgG anti-SARS-CoV-2 anti-SARS-CoV-2 humoral antibody Antibody Response Antibody testing BMI comprehension convalescent patient Convalescent patients country COVID-19 COVID-19 convalescent patient COVID-19 disease decrease detectable develop disease severity humoral humoral immune response IgG IgG antibodies IgG antibody immunodeficiency inclusion criteria Kinetics knowledge longitudinal study majority Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nucleocapsid Patient positive Protein Re-infection robust RT- PCR SARS-CoV-2 SARS-CoV-2 nucleocapsid serum Sex Treatment Vaccination strategies Vaccination strategy virus infection [DOI] 10.1038/s41598-022-16402-0 PMC 바로가기 [Article Type] Article
Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccineMVA-MERS-S 백신으로 후기 3차 면역 후 MERS-CoV-스파이크 특이적 B 세포 및 항체의 지속성Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] MERS, 임상, 진단, [키워드] Administered antibody antibody isotypes B cell B cell response B cells binding boost booster booster vaccination caused coronavirus Coronavirus 2019 COVID-19 Cytometry ELISA ELISPOT ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunospot flow cytometry Frequency highlight homologous IgG IgG ELISpot IgG subclasses IgG1 immune immune persistence immune response immune responses Immunity immunization Immunoglobulin ImmunoSpot increase isotypes late booster vaccination long-term immunity longitudinal analysis memory B memory B cells MERS MERS coronavirus MERS-CoV MERS-S Middle East Middle East respiratory syndrome modified vaccinia virus MVA-MERS-S neutralization capacity neutralization test Neutralizing Neutralizing antibodies neutralizing antibody persistence Phase 1 phase 1 trial plaque-reduction neutralization test PRNT50 Protein respiratory Respiratory disease significantly Spike protein syndrome T and B cell responses T cell T cell responses Vaccination strategies Vaccine Viral Viral vector vaccine [DOI] 10.1016/j.xcrm.2022.100685 PMC 바로가기 [Article Type] Article
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome Research Published on 2022-07-192022-10-05 Journal: Nature Communications [Category] 바이오마커, 임상, [키워드] antibody Antibody titer baseline binding booster vaccination clinical trial conducted coronavirus epitope Epitopes evaluate exploratory expressing homologous humoral responses identify IgG immunization immunogenic Increased magnitude MERS-CoV Middle East neutralization Neutralizing pandemic participant Phase 1 RBD respiratory syndrome coronavirus responses S2 subunit Safe spike glycoprotein Support syndrome the receptor-binding domain trial participant trials two-dose regimen vaccination vaccine candidate [DOI] 10.1038/s41467-022-31557-0 [Article Type] Research
Immunogenicity and protective potential of chimeric virus-like particles containing SARS-CoV-2 spike and H5N1 matrix 1 proteinsSARS-CoV-2 스파이크 및 H5N1 매트릭스 1 단백질을 포함하는 키메라 바이러스 유사 입자의 면역원성 및 보호 가능성Article Published on 2022-07-182022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ADE antibody avoidance candidate vaccine caused cellular immunity chimeric coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic effective expression fused H5N1 Humoral immunity IgG IgG1 IgG2a immunogenicity induce mice mouse-adapted strain pandemic Prevent PROTECT Protective Protein protein expression robust SARS-CoV-2 SARS-CoV-2 specific antibody SARS-CoV-2 spike SARS-CoV-2 vaccine Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spike spike gene stability stimulate sustained Vaccine virus infection Virus-like particle virus-like particle (VLP) VLP VLPs wild-type SARS-CoV-2 [DOI] 10.3389/fcimb.2022.967493 PMC 바로가기 [Article Type] Article
[Clinical features of children with coronavirus disease 2019 Delta variant infection after vaccination with inactivated SARS-CoV-2 vaccine][SARS-CoV-2 비활성화 백신 접종 후 코로나바이러스 질환 2019 델타 변이체 감염 아동의 임상적 특징]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Alanine alanine aminotransferase aspartate Aspartate aminotransferase B lymphocyte B lymphocytes C-reactive protein caused CD3 Child children children with COVID-19 China Chinese clinical clinical feature Clinical features clinical symptom Clinical symptoms coronavirus coronavirus disease Coronavirus disease 2019 cough Course COVID-19 creatine creatine kinase Creatine kinase-MB creatinine Ct value cytokine Cytokines Delta delta variant disease disease classification elevated English enrolled epidemiological data expectoration feature Fever Gender hospital Hospitalized IgG immune function inactivated incidence rate incidence rates Infection Laboratory laboratory examination Lactate lactate dehydrogenase leukocyte lymphocyte myocardial injury no significant difference nucleic acid Peripheral blood positive rate procalcitonin proportion reduce Retrospective analysis SARS-CoV-2 SARS-CoV-2 vaccine serum creatinine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significantly higher significantly lower T lymphocyte two group two groups vaccination Vaccine was performed [DOI] 10.7499/j.issn.1008-8830.2203174 PMC 바로가기 [Article Type] Article
Seroprevalence and dynamics of anti-SARS-CoV-2 antibodies: a longitudinal study based on patients with underlying diseases in Wuhan항-SARS-CoV-2 항체의 혈청유병률 및 역학: 우한의 기저 질환 환자를 기반으로 한 종단 연구Article Published on 2022-07-152022-09-11 Journal: Respiratory Research [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI All participant All participants anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Assessing asymptomatic patient asymptomatic patients baseline Blood blood sample Blood samples change Community COVID-19 Diseases door effective family members feature Follow-up Government healthcare Households Humoral immunity IgA IgG IgG antibodies IgG antibody IgG titer IgG titers IgM immunoglobulins individual infected with SARS-CoV-2 list Local local government natural infection Neutralising Antibodies neutralising antibody Neutralizing antibody titer no significant difference nucleocapsid protein participant Participants Patient positive Prevention and control Protein provided questionnaire Randomly remained Research SARS-CoV-2 SARS-CoV-2 nucleocapsid selected serological Seroprevalence serum sample serum samples significantly Single natural infection symptomatic patient Symptomatic patients telephone tested titer total antibodies total antibody underlying disease underlying diseases venous venous blood was collected were assessed Wuhan [DOI] 10.1186/s12931-022-02096-5 PMC 바로가기 [Article Type] Article
[Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases][소아 오미크론 변이체 감염 회복기 혈청 IgG 항체 변화 : 110건 분석]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis antibody BBIBP-CorV Beijing Biological Biological products booster vaccination caused Child children China Chinese citation Clinical data Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Diagnosis disease dose doses English four group four groups groups IgG IgG antibody inactivated Inactivated vaccine Infection journal no significant difference no significant differences Nucleic acid detection omicron pediatrics protective effect RBD IgG Recovery stage reduction in respiratory Retrospective analysis route SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 nucleic acid SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum IgG Serum level severe acute respiratory syndrome Coronavirus Sex significant difference significant differences significantly higher significantly lower Sinopharm status the vaccine Tianjin Transmission two group two groups vaccination Vaccine variant was performed [DOI] 10.7499/j.issn.1008-8830.2204074 PMC 바로가기 [Article Type] Article
Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273SARS-CoV-2의 면역 역학은 면역 억제된 류마티스 관절염 또는 mRNA-1273 예방 접종을 받은 다발성 경화증 환자를 경험했습니다.Article Published on 2022-07-152022-09-12 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence acute respiratory syndrome affected analyzed anti-CD20 antibody Autoimmune Autoimmune disease Autoimmune diseases B cell response benefit CD4 CD8 Cell cellular cellular immunity central memory circulating condition coronavirus COVID-19 COVID-19 mRNA vaccine development disease Disease activity European European Commission first vaccination flow cytometry follicular HCs healthy control Horizon Human humanized humoral Humoral immunity IgG immune immune response Immunity immunology Immunosuppressant immunosuppressants Immunosuppressed increased risk Infection Inflammation leadership longitudinal marker Medicine methotrexate Moderna monoclonal antibody monotherapy mRNA mRNA-1273 MTX multiple sclerosis Netherland organization outcome Patient patients treated preserved recall Research resulting rheumatoid arthritis SARS-CoV-2 second vaccination shielding significantly supported suppress sustained T cell T cell response T cells T helper the SARS-CoV-2 treated Treatment union vaccination Vaccine vulnerable patients whole blood sample [DOI] 10.7554/eLife.77969 PMC 바로가기 [Article Type] Article