Manipulation of the Innate Immune Response by Varicella Zoster Virus수두 대상포진 바이러스에 의한 선천 면역 반응의 조작Review Published on 2020-01-242023-05-31 Journal: Frontiers in Immunology [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] Herpes zoster (HZ) immune evasion innate immune response Varicella (chickenpox) Varicella–Zoster virus [DOI] 10.3389/fimmu.2020.00001 PMC 바로가기 [Article Type] Review
Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple SitesArticle Published on 2019-12-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] activate caused cleavage cleaving coronavirus death demonstrated DF2 Diseases evade Feline infectious peritonitis Genome Host IFN response IFN-β immune response induce Infection inhibited innate immune response interferon regulatory factor interferon-stimulated gene IRF3 ISG mechanism Multiple NEMO NF-κB non-structural protein nsp5 nuclear peritonitis Phosphorylation Production promoter provide recruitment reduced reported Research Sendai virus Signaling Site TANK TRAF Type type I Type I IFN type I interferon virulent virus [DOI] 10.3390/v12010043 PMC 바로가기 [Article Type] Article
Single-walled carbon nanotubes repress viral-induced defense pathways through oxidative stressArticle Published on 2019-11-012023-06-23 Journal: Nanotoxicology [Category] 신종인플루엔자, [키워드] Infection influenza A virus innate immune response oxidative stress Single-walled carbon nanotubes [DOI] 10.1080/17435390.2019.1645903 PMC 바로가기
Susceptibility of Chickens to Low Pathogenic Avian Influenza (LPAI) Viruses of Wild Bird– and Poultry–Associated SubtypesArticle Published on 2019-10-312023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus chickens innate immune response Low pathogenic avian Influenza poultry shedding wild birds [DOI] 10.3390/v11111010 PMC 바로가기 [Article Type] Article
Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus InfectionsReview Published on 2019-10-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition alphavirus caused Clinical outcome Coronaviruses evade Genetic Host human pathogen immune evasion immune response immunopathology implicated Infection inflammatory disease Innate innate immune innate immune evasion innate immune response innate immune system interferon less molecular mechanism Pathogenesis pathology positive-sense single-stranded RNA viruses prevalent protective role public health replication capacity Research RNA single-stranded the interferon type I and III interferons viral disease viral infection viral pathogenesis virus viruses [DOI] 10.3390/v11100961 PMC 바로가기 [Article Type] Review
Transcriptome analysis of PK-15 cells in innate immune response to porcine deltacoronavirus infectionResearch Article Published on 2019-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] affected affecting age alteration Antiviral Cell coronavirus DEGs described diarrhea diarrheal differentially expressed gene disease enrichment analysis exhibited expression function gene expression profile gene function Gene ontology host cell host cells hpi immune-related gene indicated Infection infections innate immune innate immune response Kyoto mechanism miRNA modulation Outbreaks pathway performed PK-15 Porcine deltacoronavirus post infection predicted Prevent problems provide research finding RNA sequencing screened signaling pathway signaling pathways transcriptome analysis uninfected [DOI] 10.1371/journal.pone.0223177 PMC 바로가기 [Article Type] Research Article
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus–Host InteractionsArticle Published on 2019-08-132022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] airway epithelium Cell Cell culture Combined Culture cultures expression facilitate Factor fluorescence-activated cell sorting fluorescent functional Genetic hAEC HCoV-229E Host host gene expression Human human airway epithelial human airway epithelial cell cultures human coronavirus 229E human respiratory epithelium human respiratory virus in vitro inhibitor innate immune response Interaction knockdown lentiviral Modification modulated molecular not affected platform primary cell primary human cell Protein protocol reporter respiratory respiratory syncytial virus respiratory virus respiratory viruses target cells transgenic unique virus infection Virus-host interactions virus–host interaction Y-27632 [DOI] 10.3390/v11080747 PMC 바로가기 [Article Type] Article
Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune systemResearch Published on 2019-08-052022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Activation amino acid residue analyzed canonical cause cells compose coronavirus Critical cytokine production Degradation demonstrated develop diarrhea domain dose-dependent inhibition downregulation enzyme activity evade exhibited family Coronaviridae gastroenteritis Host host immune system host innate immunity identify immunoprecipitation individual Infection inflammatory factors inhibit inhibiting inhibitory effect innate immune innate immune response involved IκBα modulating modulation mRNA expression NF-κB NF-κB NF-κB signaling non-structural protein nonstructural protein 3 Nsp3 nuclear nuclear translocation p65 Pathogenesis pathway Phosphorylation PLP PLP2 previous study Protein provide quantitative PCR reporter Result signaling pathway TGEV transmissible gastroenteritis virus ubiquitination Viral protein virus was used watery [DOI] 10.1186/s12985-019-1206-9 PMC 바로가기 [Article Type] Research
Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked PolyubiquitinationImmunology Published on 2019-05-092022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Activation antiviral response binding coronavirus demonstrated diarrhea double-stranded RNA Host host antiviral response IFN-β IFN-β immune Infection infections inhibit inhibiting innate immune response interfere interferon mechanism N protein N-terminal Newborn nucleocapsid nucleocapsid protein outbreak PDCoV porcine RIG-I Production promoter Protein receptor RIG-I signaling molecules stimulated suppressed Surveillance therapeutic target TNF ubiquitination Vaccine vesicular stomatitis virus virus infection Virus-host interaction vomiting VSV [DOI] 10.3389/fimmu.2019.01024 PMC 바로가기 [Article Type] Immunology
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine DevelopmentReview Article Published on 2019-04-072022-10-29 Journal: Journal of Immunology Research [Category] Coronavirus, MERS, [키워드] Activation Adaptive immune response adjuvant Antigen approved cellular response Combination contribute country development died Dipeptidyl peptidase-4 DPP4 effective ENhance Factor globe help highlight Host immune response infected patients infections innate immune response key factor knowledge mechanism MERS-CoV Middle East Neutralizing antibodies Pandemics Patient proinflammatory receptor respiratory respiratory syndrome coronavirus response risk Signaling Spike protein Spread therapy Treatment Vaccine Vaccine development virus WHO World Health Organization [DOI] 10.1155/2019/6491738 PMC 바로가기 [Article Type] Review Article