Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-upResearch Article Published on 2021-12-072022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] acute COVID-19 age antiviral therapy baseline benefit breath city cohort study cough COVID-19 COVID-19 patient COVID-19-related symptom Cox proportional hazard discharge Dyspnea evaluate fatigue female gender Follow-up Frequency Health healthcare hospital hospital discharge Hospital stay hypertension identify increased risk interferon King less likelihood logistic regression model Lung disease majority median men multivariable multivariate Patient PCR-confirmed COVID-19 patient persistence physician predict predictor prospective cohort rehabilitation reported reported symptom required Result returned risk factor Risk factors Saudi Arabia survivor Symptom Symptoms syndrome treated were used [DOI] 10.1371/journal.pone.0260568 PMC 바로가기 [Article Type] Research Article
Signature of long-lived memory CD8 + T cells in acute SARS-CoV-2 infection급성 SARS-COV-2 감염에서 장기 기억 CD8 + T 세포의 시그니처Article Published on 2021-12-072022-08-31 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerated acute infection acute SARS-CoV-2 infection acute viral infection adaptive Adaptive immunity Blood CCR7 CD45 CD45RA CD8 cells cellular characterized circulating clone clones COVID-19 pandemic effector memory evidence of Express facilitate flow cytometry hallmark IL-7 immune response Immunity Immunological memory Infection interferon low expression maintain memory memory T cell memory T cells outbreak pathogen patients with COVID-19 precursor precursors proliferation question Rapamycin Re-infection SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells Sequencing signature stimulated T cell T cell receptor T cells transcriptional Transcriptome transcriptomes Viral viral infection [DOI] 10.1038/s41586-021-04280-x PMC 바로가기 [Article Type] Article
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Article Published on 2021-12-072022-10-04 Journal: Nature Communications [Category] SARS, 임상, 진단, [키워드] Air-liquid interface airway Antiviral Cell change Critical Culture Delayed epithelial epithelial cell epithelial cell types host response IFN IFN response IFNβ induce Infection initiate innate immune response Innate immunity Interaction interferon interferon-stimulated gene interferons Mucosal immunology nasal nasal epithelium outcome paracrine Pathogenesis proteomics provided recombinant IFN response restrict SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 viral replication Single Cell Single-cell RNA sequencing tissue Transcription Transmission type I viral gene expression widespread [DOI] 10.1038/s41467-021-27318-0 PMC 바로가기 [Article Type] Article
Characteristics and outcomes of hospitalized patients with cardiovascular complications of COVID-19Original Article Published on 2021-12-062022-10-30 Journal: Journal of Cardiovascular and Thoracic Research [Category] COVID-19, [키워드] acute coronary syndromes Admission all-cause mortality arrhythmia cardiovascular complication cardiovascular diseases Care cerebrovascular accident Clinical outcome cohort study Complication complications concerning COVID-19 COVID-19 patients CV complication CV complications diastolic died discharge disease disease severity dysfunction Ejection fraction elevated enrolled form greater heart failure hospital discharge Hospitalization hospitalized patient increased mortality independent predictor interferon IQR median age Mortality Myocardial infarction myocarditis N-terminal occurred outcome Patient patients preserved prevalent pro-B-type natriuretic peptide proportion retrospective risk significantly higher single-center study population thrombosis troponin I ventricular with COVID-19 yielding [DOI] 10.34172/jcvtr.2021.53 PMC 바로가기 [Article Type] Original Article
Treatment of Coronavirus Disease 2019 Patients With Prolonged Postsymptomatic Viral Shedding With Leflunomide: A Single-center Randomized Controlled Clinical TrialLeflunomide로 장기간의 증상 후 바이러스 방출이 있는 코로나바이러스 질병 2019 환자의 치료: 단일 센터 무작위 통제 임상 시험Randomized Controlled Trial Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] addition administration adult COVID-19 patient adverse events approved assigned benefit Chain Reaction clinical combined treatment Complete conducted confidence interval Controlled coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Efficacy and safety evaluate hazard ratio Hospital stay Hospitalized inhibitor interferon Interferon alpha interferon alpha 2a interquartile range IQR leflunomide median nebulized once daily Open-label open-label trial Patient patients treated PCR PCR positivity polymerase chain polymerase chain reaction primary endpoint Prolonged Randomized Randomly receive recipient SARS-CoV-2 shedding the patient treat Trial viral shedding [DOI] 10.1093/cid/ciaa1417 PMC 바로가기 [Article Type] Randomized Controlled Trial
Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19경증에서 중요한 코비드 -19 환자의 종 방향 사이토 카인 프로파일Observational Study Published on 2021-12-062022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 임상, [키워드] Administered adult COVID-19 patient adult COVID-19 patients ARDS association best Biomarker blood sample Blood samples chemokine clinical endpoint Clinical endpoints coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critically ill critically ill patients cytokine cytokine profile Cytokine release syndrome Cytokines disease severity dose early phase elevated evaluate followed by gamma interferon growth highest Hong Kong Hospitalized host response IL-10 IL-1ra IL-5 IL-6 IL-8 immune Inflammation intensive care interferon interferon-induced protein interleukin IP-10 late phase longitudinal Macrophage MCP-1 mDC mechanical ventilation MIG Mild MIP-1α moderate monocyte monocyte chemoattractant protein-1 monokine Norepinephrine observational study Patient patient group patient groups patients predict predicted profile proinflammatory prospective observational study public hospitals receptor receptor antagonist SARS-CoV-2 Seven severity symptom onset was performed with COVID-19 [DOI] 10.3389/fimmu.2021.763292 PMC 바로가기 [Article Type] Observational Study
Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modificationArticle Published on 2021-12-012023-06-03 Journal: Emerging Microbes & Infections [Category] B형 간염, Fulltext, [키워드] ALKBH Epitranscriptomics HCC hypoxia interferon Liver cancer METTL [DOI] 10.1080/22221751.2021.2006580 PMC 바로가기
Performance of the T-SPOT Ⓡ.COVID test for detecting SARS-CoV-2-responsive T cellsSARS-CoV-2 반응성 T 세포 검출을 위한 T-SPOT Ⓡ.COVID 검사 성능Article Published on 2021-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] Activation Adaptive immune response anti-N IgG Blood common cold common cold coronavirus control group coronavirus COVID-19 cross-reactive detect Diagnosis ELISPOT evaluate IGRA Immunoglobulin Infection interferon interferon-gamma release assay less methodology NAAT nucleic acid nucleic acid amplification nucleic acid amplification test nucleocapsid participant Participants participants with SARS-CoV-2 Patient peptides performance performed reactive response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serology serology test seropositive T cell T cell response T cell responses T cells T-cell T-cells T-SPOT.COVID [DOI] 10.1016/j.ijid.2021.09.073 PMC 바로가기 [Article Type] Article
Pentoxifylline effects on hospitalized patients with COVID19: A randomized, double-blind clinical trialCOVID19로 입원한 환자에 대한 Pentoxifylline 효과: 무작위, 이중 맹검 임상 시험Randomized Controlled Trial Published on 2021-12-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] 1:1 analyzed Anti-inflammatory Anticoagulant antiviral effects assigned baseline changed clinical clinical benefit Clinical characteristics Clinical outcome clinical outcomes clinical trial complications conducted COVID-19 COVID-19 complications demographics dose double-blind Effect Efficacy and safety evaluate Factor glutathione hospital Hospital stay hospitalized patient hospitalized patients Hydroxychloroquine ICU admission IL-6 inclusion criteria individual Inflammation Inflammatory interferon interleukin interleukin-6 intervention group intubation Lopinavir Lopinavir/ritonavir National no significant differences not differ not significant offer oxidative stress Patient patients with COVID-19 Pentoxifylline Placebo placebo group placebo-controlled Primary outcome Randomized randomized clinical trial Randomly recruited regimen Ritonavir safety profile Secondary outcomes Serum level shown significant difference significantly the mean the placebo group two group two groups with COVID-19 [DOI] 10.1016/j.intimp.2021.108227 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clash of the titans: interferons and SARS-CoV-2타이탄의 충돌: 인터페론과 SARS-CoV-2Article Published on 2021-12-012022-09-11 Journal: Trends in immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 coronavirus Defense effector protein effector proteins highlight Innate immunity Interaction interferon interferon-stimulated genes interferons modulate nuance nuances question responses SARS-CoV-2 severe acute respiratory syndrome Coronavirus virus virus–host interaction. viruses [DOI] 10.1016/j.it.2021.10.009 PMC 바로가기 [Article Type] Article