SARS-CoV-2 spike – Page 37 – Communicable Diseases Research

Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals

혈청 양성 및 혈청 형성 개인에서 SARS-CoV-2 mRNA 백신 투여 동안 체액 면역 반응

Research Article

Published on 2021-07-262022-09-01
Journal: BMC Medicine [Category] SARS, 진단,

RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota

RS-5645는 폐 미생물총을 조절하여 SARS-CoV-2 스파이크 단백질 및 LPS에 의해 유도된 염증성 사이토카인 폭풍을 약화시킵니다

Research Paper

Published on 2021-07-252022-09-10
Journal: International Journal of Biological Sciences [Category] SARS, 바이오마커,

[키워드] 16S rRNA 4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone (RS-5645) abundance Activation addition alveolar alveoli Amino acid amino acid metabolism Analysis attenuate biogenesis cause of death CD11b CD45 CD56 CD56+ cellular COVID-19 patients Critically ill cytokine death elevated exhibited expression Host IFNγ indicated Inflammatory inflammatory cell inflammatory cell infiltration inflammatory cells Inflammatory cytokine Inflammatory cytokine storm inflammatory factor storm inflammatory storm inhibited Intervention involved KEGG LPS lung tissue manifested metabolism metabolite mice microbiota microorganism microorganisms modulating mononuclear cell mononuclear cells mRNA mRNAs overlapping Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Protein pulmonary microbiota qPCR reduce reduced Research rRNA S protein SARS-CoV-2 (COVID-19) spike protein SARS-CoV-2 spike SARS-CoV-2 spike protein Secondary Metabolite severely and critically ill COVID-19 patients significantly Streptococcus the S protein the SARS-CoV-2 translation unique
[DOI] 10.7150/ijbs.63329 PMC 바로가기 [Article Type] Research Paper

CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In Vitro

CAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화

Immunology

Published on 2021-07-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2
[DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France

프랑스 북동부 어린이와 성인의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 체액 면역

Research Paper

Published on 2021-07-232022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 임상, 진단,

[키워드] 229E Action adolescents and adults age all age group all age groups antibody antibody level antibody levels Antibody Response Antibody responses Betacoronavirus Biology children collected COVID-19 COVID-19 pandemic cross-protective immunity cross-reactivity cross-sectional disease Emerging infectious diseases European Evidence finding France French funding HCoV highest HKU1 Horizon Hospital admission human coronavirus Immunity immunoassays individuals infected individuals Infection infection with SARS-CoV-2 infections Infectious disease Infectious diseases large cohort levels of antibody lowest luciferase Multiplex assay neutralisation assay NL63 Non-COVID-19 observé OC43 pseudotype Research SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody seasonal coronavirus seasonal coronaviruses Sero-epidemiology seronegative seropositive individual seropositive individuals Seroprevalence serum sample serum samples severity specific antibodies specific antibody spike supported union unit were assessed
[DOI] 10.1016/j.ebiom.2021.103495 PMC 바로가기 [Article Type] Research Paper

Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice

이중 항원 코비드 -19 백신을 사용한 비강 + 피하 주요 예방 접종은 마우스에서 T- 세포 및 항체 반응을 유도한다.

Article

Published on 2021-07-212022-09-01
Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법,

Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study

COVID-19 환자에서 항체의 동적 특성 분석: 13개월 연구

Immunology

Published on 2021-07-202022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antibody Antibody Response characteristic collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 described detective domain dynamic early stage effective Extracellular Hospitalized IgA level IgA levels IgM Immunity Immunoglobulin immunoreaction Infection Neutralizing activity Neutralizing antibodies nucleocapsid protein observation offered onset of symptom Patient POS Postinfectious quantified reaction Receptor binding domain Receptor-binding domain remained respiratory SARS-CoV-2 SARS-CoV-2 spike Screen serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein target targets vaccination worldwide pandemic
[DOI] 10.3389/fimmu.2021.708184 PMC 바로가기 [Article Type] Immunology

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다

Research Article

Published on 2021-07-162022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종,

[키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic
[DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

SARS-CoV-2 스파이크 L452R 변종은 세포 면역을 회피하고 감염력을 증가시킵니다

Article

Published on 2021-07-142022-09-11
Journal: Cell Host & Microbe [Category] Coronavirus, MERS, SARS, 변종, 진단,

[키워드] ACE2 Affect affinity Antigen B.1.1.298 B.1.427/429 B.1.617 cellular cellular immunity COVID-19 entry receptor escape evade Evolution Host human leukocyte antigen Humoral immunity immune resistance increase investigated L452R leukocyte Mutation naturally occurring variants pandemic phenotype promote Receptor-binding domain receptor-binding motif SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Spike protein spike stability the receptor-binding domain the SARS-CoV-2 These data variant Viral viral infectivity viral replication Y453F
[DOI] 10.1016/j.chom.2021.06.006 PMC 바로가기 [Article Type] Article

Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology

SARS-CoV-2 항체 혈청 검사가 음성인 회복기 COVID-19 환자의 반응성 T 세포

Immunology

Published on 2021-07-122022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료법,

[키워드] analyzed Antibody Response CD4+ T cell convalescent convalescent COVID-19 patient convalescent individuals convalescent patient Convalescent patients coronavirus Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patients cytokine detectable disease course elicited Endemic flow cytometry Frequency HCoV HCoV-229E healthy control healthy controls human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC43 (HCoV-OC43) IFN IL-2 Mild negative nucleocapsid peptide peptide pool persistence positive question raise reactive RT-PCR SARS-CoV-2 SARS-CoV-2 spike seronegative seropositive serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies specific antibody Stimulation T cell T cell response T cells TNFα undetectable Viral viral control
[DOI] 10.3389/fimmu.2021.687449 PMC 바로가기 [Article Type] Immunology

Use of monoclonal antibody therapy for nosocomial SARS-CoV-2 infection in patients at high risk for severe COVID-19: experience from a tertiary-care hospital in Germany

중증 COVID-19 고위험 환자에서 병원 내 SARS-CoV-2 감염에 대한 단일클론항체 요법 사용: 독일 3차 병원의 경험

Brief Report

Published on 2021-07-092022-09-12
Journal: Infection [Category] SARS, 진단,