Drug repurposing – Page 38 – Communicable Diseases Research

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

Review

Published on 2021-03-052022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

The Role of Immunogenetics in COVID-19

COVID-19에서 면역유전학의 역할

Review

Published on 2021-03-052022-09-10
Journal: International Journal of Molecular Sciences [Category] 변종, 신약개발, 유전자 메커니즘,

[키워드] AB0 Asymptomatic available data clinical manifestations coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm disease Drug repurposing Evolution experimental evidence genetic variability Genetic variant genetic variants help HLA Host immune response immune system Immunogenetics immunosenescence Impact IMPROVE KIR knowledge life-threatening maintenance molecular mechanism Multiorgan outcome reactivity Research Respiratory failure role SARS-CoV-2 SARS-COV-2 infection susceptibility the disease Therapeutic strategies Treatment Variability variety Viral viral infection viral infections
[DOI] 10.3390/ijms22052636 PMC 바로가기 [Article Type] Review

SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19

Review

Published on 2021-03-032023-07-01
Journal: Expert opinion on therapeutic patents [Category] SARS,

[키워드] COVID-19 Drug repurposing nucleoside inhibitors RNA polymerase SARS-CoV-2
[DOI] 10.1080/13543776.2021.1880568 PMC 바로가기 [Article Type] Review

COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging Epidemics

Research article

Published on 2021-03-012022-10-05
Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 신약개발, 치료제,

A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment

COVID-19 치료를 위한 세팔로스포린 항생제 및 항 C형 간염 약물 유도체 식별을 위한 컴퓨터 약물 용도 변경 접근법

Article

Published on 2021-03-012022-08-31
Journal: Computers in biology and medicine [Category] MERS, SARS, 신약개발, 치료제,

[키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amalgam Analysis antibiotic antiviral agent Antiviral agents approach backbone atom Bacterial bacterial pneumonia Bank binding binding free energy caused Ceftaroline Ceftaroline fosamil Chemical complex Computational drug coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cys145 database death derivative drug Drug repurposing free energy Free energy calculations Glu166 Gly143 HCV hepatitis C hepatitis C virus His41 hydrogen Hydrogen bond hydrogen bonds identify indicated indication information inhibitor inhibitors Interaction investigated M pro MD simulations molecular molecular dynamics offer pharmacokinetic Pneumonia potential energy Preclinical Testing profiles Protease inhibitor Protein repurposing residue respiratory RMSD SARS-CoV-2 SARS-CoV-2 main protease Seven severe acute respiratory syndrome Coronavirus Side effects suggested supported telaprevir Treatment Virtual screening
[DOI] 10.1016/j.compbiomed.2020.104186 PMC 바로가기 [Article Type] Article

Drug repurposing for COVID-19 via knowledge graph completion

지식 그래프 완성을 통한 COVID-19에 대한 약물 용도 변경

Article

Published on 2021-03-012022-08-31
Journal: Journal of biomedical informatics [Category] MERS, SARS, 변종, 신약개발, 치료제,

Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs

SARS-CoV-2에 대한 네트워크 분석 및 분자 매핑을 통해 약물 표적을 밝히고 임상적으로 개발된 약물의 용도 변경

Article

Published on 2021-03-012022-08-31
Journal: Virology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] (hydroxychloroquine) Analysis Antibiotics antimalarial antiretroviral Azithromycin BCL-2 biological process carried chemokine Chemokine receptor clinically Combination coronavirus dietary supplement dietary supplements disease networks docking docking analysis docking study drug drug combination Drug repurposing drug target effective EGFR ErbB Estrogen event FoxO global pandemic GnRH HIF-1 host inflammatory response Hydroxychloroquine IL-17 insulin Interaction involved Jak-STAT KEGG pathway analysis life cycle Lopinavir LOPINAVIR AND RITONAVIR MAPK modulation molecular molecular docking molecular mechanism morbidity and mortality mortality rate multiple pathway multiple pathways network Neurotrophin novel Novel coronavirus Ontology PARP pathway platelet activation predict PRKCB Process analysis receptor reduce Ritonavir SARS-CoV-2 SARS–CoV–2. signaling pathway STAT suggested target targets thyroid hormone TNF Toll-like receptor Treatment VEGF Viral viral infection viral infectivity viral life cycle viral replication virus Vitamin Vitamin C
[DOI] 10.1016/j.virol.2020.12.006 PMC 바로가기 [Article Type] Article

Computational drug repurposing study of the RNA binding domain of SARS-CoV-2 nucleocapsid protein with antiviral agents

Article

Published on 2021-03-012023-07-13
Journal: Biotechnology progress [Category] SARS,

[키워드] COVID-19 CoVs Drug repurposing MD simulations molecular docking N protein RNA binding domain SARS-CoV-2
[DOI] 10.1002/btpr.3110 PMC 바로가기

In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19

Pharmacology

Published on 2021-02-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE2 Against Analysis analyzed approved drugs artificial artificial neural networks cells clinical trials Compound COVID-19 downloaded drug Drug repurposing drugs goblet secretory cells highest Human human tissues identify ileal absorptive enterocyte immune system in silico interactome lung nasal network Neural overexpressed Patient performed Potential potential therapeutic target predict Protein receiver operating characteristics repurposing RNA screened severe COVID-19 patients significantly Single-cell RNA sequencing System target therapeutic target TMPRSS2 treating COVID-19 patient Treatment type II pneumocytes urgency
[DOI] 10.3389/fphar.2021.598925 PMC 바로가기 [Article Type] Pharmacology

Exploring existing drugs: proposing potential compounds in the treatment of COVID-19

Research article

Published on 2021-02-262022-10-05
Journal: Heliyon [Category] 신약개발, 유전자 메커니즘, 치료법, 치료제,

[키워드] ACE2 addressed alignment approved basic candidate characterized Compound confirmed case conserved conserved region COVID-19 COVID-19 epidemic COVID-19 situation database death docking drug Drug repurposing drugs effective evolutionary relationship identify in vitro in vivo inhibit International Johns Hopkins University Lopinavir microorganism Molecular modeling molecular target much higher Off Pacritinib Phylogenetic tree public health emergency Region Remdesivir reported researcher Safe safety profile SARS-CoV-2 SARS-COV-2 infection searched Seven similarity South Asian strain TMPRSS2 Treatment virus viruses was used were used World Health Organization
[DOI] 10.1016/j.heliyon.2021.e06284 [Article Type] Research article