A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemicResearch Article Published on 2020-10-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] Algorithm approach autonomous Contact COVID-19 COVID-19 pandemic criteria develop feasibility flexible functions geometric healthcare Healthcare system heterogeneous ICU identify indicate intensive care intensive care unit Local local health service National Health Service Patient random resource risk Spain Spanish transfer United Kingdom [DOI] 10.1371/journal.pone.0241027 PMC 바로가기 [Article Type] Research Article
Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular CondensatesArticle Published on 2020-10-182022-10-28 Journal: Viruses [Category] COVID-19, [키워드] aerosol droplet aerosol droplets aggregate aggregates Analysis antiviral responses benefit bioinformatics biomolecular condensate cellular condensate conserved contribute copper deregulation disease disease-causing Diseases domain Dynamics eliminated feature function functions Gene Expression genomic RNA hallmark homeostasis Infection insoluble interfere Ion liquid-liquid phase separation mechanism membraneless organelle Meta-analysis modify modulate morphology neurodegenerative Neurodegenerative disease Neurological disease Neurological diseases nucleocapsid nucleocapsid protein Numerous organelle ortholog pan-virus persistence phase physiological plaque prion-like disordered protein domain promote Protein protein domain RBD RBDs Regulation Replication representing required Research responsible retrovirus RNA-binding domain separation stress granule therapeutic viral genomic RNA Viral protein virus virus infection vRNA while Zinc zinc finger motif [DOI] 10.3390/v12101179 PMC 바로가기 [Article Type] Article
Lipoprotein concentrations over time in the intensive care unit COVID-19 patients: Results from the ApoCOVID study중환자실 COVID-19 환자의 시간 경과에 따른 지단백질 농도: ApoCOVID 연구 결과Research Article Published on 2020-09-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Admission Anti-inflammatory antioxidant association Bacterial Bacterial sepsis bacterial superinfection caused change cholesterol clearance Concentration conducted consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia dead patient decrease Diagnosis functions global pandemic HDL HDL-C HDLs High-density lipoprotein High-density lipoproteins Hospitalization Hospitalized ICU ICU admission ICU patient incidence increase in intensive care LDL cholesterol LDL-C lipopolysaccharides lipoprotein Lipoproteins Low-density lipoprotein low-density lipoproteins Mortality neutralize nonsurvivors outcome outcomes Particle Particles Patient pleiotropic Pneumonia profile Prospective Study reference values reported respiratory Result Sepsis Severe COVID-19 pneumonia statistically significant superinfection survival survivor Transport university hospital VAP Ventilator-associated pneumonia were assessed [DOI] 10.1371/journal.pone.0239573 PMC 바로가기 [Article Type] Research Article
Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformansCryptococcus neoformans에서 가져온 쿼럼 센싱 펩타이드에 의해 제어되는 전사 인자의 게놈 연관성을 조정합니다.Research Article Published on 2020-09-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Affect association binding Cell Cell density cell surface receptor cell wall change chromatin immunoprecipitation Control control cell Coordinate Cryptococcus Cryptococcus neoforman Cryptococcus neoformans Deletion eukaryotic expression form function functions fungal fungal pathogens Gene Expression Genes Genetic genomic genomic studies genomic study human body Hypothesis identify Impact infect Macrophage macrophages mating mechanism Meningitis microbe modulate modulating pathogen pathogenic Pathogens peptide predicted promote promoters proximal quorum regulated required reveal secreted surface receptor target transcription factor transcription factors virulence whole-genome [DOI] 10.1371/journal.pgen.1008744 PMC 바로가기 [Article Type] Research Article
Modeling the effects of contact tracing on COVID-19 transmissionResearch Published on 2020-09-212022-10-28 Journal: Advances in Difference Equations [Category] COVID-19, [키워드] 34D20 34D23 34D45 37C75 absence basic reproduction number benefit Contact Contact tracing COVID-19 COVID-19 transmission Effect examined functions Intervention Lyapunov function mathematical mathematical model modeling Reproduction number stability [DOI] 10.1186/s13662-020-02972-8 PMC 바로가기 [Article Type] Research
Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in SilicoBrief Report Published on 2020-09-172022-10-28 Journal: Toxins [Category] COVID-19, SARS, [키워드] antibody Antiviral antiviral agent binding mechanism caused chain characterized COVID-19 docking docking result experiment functions fusion fusion protein fusion proteins high affinity in silico mice New coronavirus novel pandemic pokeweed antiviral protein Protein protein-ligand Proteins Range ribosome-inactivating proteins ricin SARS-CoV-2 Structure target the SARS-CoV-2 therapeutic Therapies Toxicity Vaccines virus [DOI] 10.3390/toxins12090602 PMC 바로가기 [Article Type] Brief Report
Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2Research Article Published on 2020-09-162022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] acute respiratory syndrome alleles Amino acid Antigen antigenicity B-cell epitope binding binding affinity Cell computational approach coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 pandemic CTL cytotoxic T lymphocyte docking downloaded effective envelope epitope Escherichia coli functions GenBank glycoprotein highly antigenic HLA HTL humans immune response Immune simulation immunogenic immunoinformatics in silico In silico cloning increased expression Infection Interaction investigated K-12 leukocyte life-threatening linkers membrane glycoprotein MEV codon Multiepitope-based subunit vaccine non-allergenic pathogenic Pneumonia Prevent Protein responsible Result SARS-CoV-2 sequence structural protein subunit suggested surface T lymphocyte the SARS-CoV-2 TLR3 Vaccine vaccine candidate [DOI] 10.1186/s40249-020-00752-w PMC 바로가기 [Article Type] Research Article
Mobile Health Apps on COVID-19 Launched in the Early Days of the Pandemic: Content Analysis and ReviewOriginal Paper Published on 2020-09-162022-10-31 Journal: JMIR mHealth and uHealth [Category] COVID-19, [키워드] app assessment criteria automated Care conducted connection content content analysis coronavirus coronavirus disease country COVID-19 COVID-19 cases data entry Day dissemination evaluate feature function functions Google Play Health health authorities Health authority Health Education help helping identify IMPROVE inclusion criteria information knowledge mHealth Mobile mobile medical app modify MOST n=36 objective outcome outcomes performed professional Result review scored self-care Surveillance Symptom The United States was used [DOI] 10.2196/19796 PMC 바로가기 [Article Type] Original Paper
Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs OutbreakEndocrinology Published on 2020-09-102022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, [키워드] ALAN anthropogenic artificial bat component Coronaviridae coronavirus coronavirus disease COVID-19 Endocrine feature functions genomic genomic integration HCoVs immune influence LIGHT majority melatonin mitigate Mutation Night nocturnal Occurrence organism outbreak pandemic physiological Potential Stress sustainability synchronization variable virus zoonotic [DOI] 10.3389/fendo.2020.00622 PMC 바로가기 [Article Type] Endocrinology
Selenium and selenoproteins in viral infection with potential relevance to COVID-19COVID-19와 잠재적 관련성이 있는 바이러스 감염의 셀레늄 및 셀레노단백질Review Published on 2020-09-102022-09-10 Journal: Redox Biology [Category] SARS, 치료제, [키워드] adaptive Adaptive immunity association benefit Chinese patient Chinese patients contribute Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19-associated inflammation Culture cure rate cytokine Cytokine activation doses Ebselen ENhance ER stress evade example explain expression functions Health Host host immunity host response hosts IL-6 immune response Immunity in viral incidence increased expression Infection inhibit SARS-CoV-2 inhibitor involved linear maturation mechanism mediator metabolite morbidity morbidity and mortality Pathogenesis pathogenic pharmacological play roles positive potential benefit potential benefits Prevent Proteases PROTECT Protective provide randomised rationale Recognition Redox-active selenium species reduced reducing required RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 protease Selenium selenoprotein Selenoproteins serum sample serum samples severity significantly significantly higher Trace element Viral viral infections viral pathogenesis virus viruses with COVID-19 [DOI] 10.1016/j.redox.2020.101715 PMC 바로가기 [Article Type] Review