B-Cell Responses in Hospitalized Severe Acute Respiratory Syndrome Coronavirus 2-Infected Children With and Without Multisystem Inflammatory SyndromeArticle Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody Antibody avidity Antibody Response antibody-secreting cell antibody-secreting cells Antiviral antiviral antibody B cell B cells B-cell response children circulation complicate coronavirus coronavirus disease COVID-19 COVID-19 patient demonstrated flow cytometry Follow-up group Hospitalized IgG immune response Immunoglobulin Infection Inflammatory MIS-C phenotype plasma Postinfectious proportion respiratory response SARS-CoV-2 sustained syndrome those with MIS-C with COVID-19 [DOI] 10.1093/infdis/jiac119 PMC 바로가기
A comprehensive review of BBV152 vaccine development, effectiveness, safety, challenges, and prospectsArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Administered Adults age antigenic approved booster children clinical development comparable country CoV COVID-19 pandemic COVID-19 severity disease Effectiveness Efficacy Emergency use Emergency use authorization generate geometric mean titer group Healthcare system Heterologous heterologous prime and boost vaccines heterologous prime-boost immune response inactivated Inactivated vaccine inactivated virus adjuvanted vaccine increase in India induce Like memory B morbidity Mortality neutralization neutralization titer original antigenic sin over pandemic pediatric phase Population prime and boost reactogenicity reduce reduction in robust safety profile SARS – CoV – 2 SARS-CoV-2 variant seroconversion rate symptomatic COVID-19 disease synergy T-cell responses TLR7/8 vaccinated individuals vaccination Vaccine vaccine challenges Vaccine development vaccine dose Vaccines variants of concern variants of concern (VOCs) virus VOCs waning immunity [DOI] 10.3389/fimmu.2022.940715 PMC 바로가기
Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidityArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome addition Analysis association B cell cancer patient Cancer patients cancer treatment Case report co-morbidity Colorectal cancer Comorbidity coronavirus correlation COVID-19 demonstrated Effect evaluated Evidence Ex vivo examined exclusion experiment HCC Hepatocellular carcinoma heterogeneity highest Immune checkpoint blockade immune dysfunction immune response immune responses Immunity immunohistochemistry immunological effect Immunological memory Immunotherapy Inflammation intra-tumor heterogeneity long-term immune memory lymphocyte Macrophage infiltration memory B cell modulate multiplex nasopharyngeal swab test Patient persistence Population positive predicted profile Reinfection response SARS-CoV-2 significantly Single-cell RNA sequencing spatial localization spatial transcriptomics Support T cell T cell dysfunction tissue tissue-localized immunity. tissues transcriptomic transcriptomic analysis Tumor tumor microenvironment understanding virus while with COVID-19 [DOI] 10.3389/fimmu.2022.978760 PMC 바로가기
Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study groupArticle Published on 2022-09-102022-11-16 Journal: Respiratory Research [Category] SARS, 치료기술, [키워드] Acquired Acute respiratory infection Affect Antibiotic treatment Antiviral approach asked Biomarkers CAP pathogens changed community-acquired pneumonia Comorbidities Comorbidity complex complications computer scientist database DelPhi diagnostics disease epidemiologists Europe Guidance Health Host identify imaging immune response immune system Immune-compromised host improvement Influenza internal and external knowledge machine machine learning Mortality next generation sequencing Pathogens patients Personalized medicine Physicians pneumococcal vaccines Pneumonia public health Research resolved risk risk stratification SARS-CoV-2 pandemic second Sequencing shown study group systemic and local The “omics” approach the patient therapy Translational research Treatment Universal universal influenza vaccine unmet need Vaccine [DOI] 10.1186/s12931-022-02117-3 PMC 바로가기
The choroid plexus and its role in the pathogenesis of neurological infectionsArticle Published on 2022-09-102022-11-15 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] Activation Alter bidirectional Blood–CSF barrier Borrelia Borrelia burgdorferi Brain Cell cells cellular response Central nervous system cerebrospinal fluid changes in chemotaxis choroid Choroid plexus circulating CNS CNS disorder cytokine dendritic cells develop Diseases disorder driving epithelia epithelial epithelial cell function greater highlight homeostasis homing hydrocephalus Immune cell immune cells immune response Immunity immunological Including induce Infection infections Inflammation inflammatory signal John Cunningham virus junction knowledge less macrophages Neuroinflammation neurological pathogen Pathogenesis Pathogens pharmacological intervention promote provide Research SARS-CoV-2 shown T cells target these cell virus Zika virus [DOI] 10.1186/s12987-022-00372-6 PMC 바로가기
Dynamics of anti-SARS-CoV-2 seroconversion in individual patients and at the population levelArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody production Asymptomatic Care COVID-19 demonstrated determine diagnosed Dynamics fraction Health hidden highest highlighting immune response Immunity individual infected with SARS-CoV-2 Infection key factor levels of antibodies Mild observation occurred pandemic Pandemics participant Patient Perspective Poland population level Population screening positive predict Registered SARS-CoV-2 SARS-COV-2 infection Seroconversion specific antibody suppress Trajectories Vaccinations [DOI] 10.1371/journal.pone.0274095 PMC 바로가기
Methodology to estimate natural- and vaccine-induced antibodies to SARS-CoV-2 in a large geographic regionArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] 95% CI antibody approach blood draw collected conducted COVID-19 case data-driven defined estimate Factors immune response methodology natural infection Older pandemic parameter participant Reproduction number SARS-CoV-2 serological data serological survey statistical vaccination vaccine-induced antibody [DOI] 10.1371/journal.pone.0273694 PMC 바로가기
COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccineArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] ACE2 Ageusia angiotensin-converting enzyme 2 Anosmia Antibody Response Antibody titer blood sample Clinical characteristics Cook County Health cough COVID-19 immunity COVID-19 symptom COVID-19 vaccine D614G demographics dependent on evaluated Fever health system humoral IC50 immune response Immunity Infection less magnitude mRNA BNT162b2 mutant N-terminal domain neutralization NTD participant PCR-confirmed positive Post-infection Prevent Primary infection Protein provided RBD Receptor binding domain Reinfection reported symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test severity significantly significantly higher spike subsequent Symptom Symptoms the antibody response the spike protein these symptoms vaccination [DOI] 10.1371/journal.pone.0273323 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기