Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural DataArtificial Intelligence Published on 2021-03-252022-10-31 Journal: Frontiers in Artificial Intelligence [Category] COVID-19, [키워드] ACE2 binding addition antibody antigenic antigenic epitope antigenic epitopes approach B-cell binding caused change common cold virus common cold viruses Complete complex conformational conformational epitope Containing Coordinate COVID-19 defined Diagnosis diagnostic epitope identify identifying Infection Mortality mortality rate overlap predicted prediction Protein RBD RBD of SARS-CoV-2 RBD-ACE2 Receptor binding domain receptor binding domian receptor complex SARS-CoV SARS-CoV-2 SARS-CoV-2 virus SARS–CoV−2 spike Spike protein Spread Strategy the RBD the SARS-CoV-2 virus the spike protein therapy vaccine production viral infection Viral protein worldwide pandemic [DOI] 10.3389/frai.2021.630955 PMC 바로가기 [Article Type] Artificial Intelligence
Modeling Predictive Age-Dependent and Age-Independent Symptoms and Comorbidities of Patients Seeking Treatment for COVID-19: Model Development and Validation StudyOriginal Paper Published on 2021-03-252022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] Admissions age analyzed app can be used caused Classifier clinical informatics Comorbidity correlated COVID-19 COVID-19 pandemic demographics development Elastic Epidemic Escalation expected feature Fever group Health care worker help hospital Hospitalization include indicated individual informatics information intensive care international public health medication Model modeling morbidity objective over pandemic participant Patient patients with COVID-19 populations positive prediction Predictive Predictive model Predictive modeling predictive models predictor Prevent reported Result risk selected Severe case severe fatigue Shortness of breath Symptom symptoms of COVID-19 tested the disease Treatment United Kingdom validation valuable resource World Health Organization Wuhan, China [DOI] 10.2196/25696 PMC 바로가기 [Article Type] Original Paper
Linear B-Cell Epitope Prediction for In Silico Vaccine Design: A Performance Review of Methods Available via Command-Line InterfaceReview Published on 2021-03-222022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] antibody production B-cell epitope BepiPred Classifier Consensus consensus prediction method COVID-19 datasets diagnostic Disease diagnosis Epitope-based vaccine faster help Immunotherapy interface linear linear epitope methodology performance prediction predictor Research researcher review SVMTriP therapy Vaccine design Vaccines was performed while [DOI] 10.3390/ijms22063210 PMC 바로가기 [Article Type] Review
Predictive Biomarkers of COVID-19 Severity in SARS-CoV-2 Infected Patients with Obesity and Metabolic SyndromeArticle Published on 2021-03-222022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] bilateral pulmonary infiltrates Biomarker can be used clinical Clinical course collected COVID-19 COVID-19 in patient COVID-19 severity creatinine death described diabete Evolution Factor hypertension IL-6 LDH metabolic metabolic syndrome Moderate COVID-19 mortality rate obesity parameter participant Patient patients patients hospitalized patients with obesity personalized therapy Pneumonia predict prediction Predictive priority prognostic biomarker prospective cohort study radiologic reported Respiratory failure SARS-CoV-2 SARS-CoV-2-infected patients severe pneumonia Symptom syndrome therapy Tocilizumab treatment for COVID-19 troponin levels [DOI] 10.3390/jpm11030227 PMC 바로가기 [Article Type] Article
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortalityResearch Published on 2021-03-222022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 30-Day mortality 95% CI acute COVID-19 acute respiratory distress adjusted age ARDS AUC Biomarker calculated changes in clinician Comorbidity Concentration control group COVID-19 COVID-19 convalescent patients COVID-19 disease severity COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 symptoms critically ill patients cut-off determine dialysis disease disease severity elevated ELISA Gender Germany healthy control healthy volunteer High-flow nasal oxygen IMPROVE Increases information Inpatient intensive care unit male management mechanical ventilation Mortality need for oxygen Non-COVID-19 Observational cohort study Odds ratio Organ failure organ support Patient Pneumonia predict prediction primary endpoint qSOFA RAGE receptor Respiratory failure Result risk secondary endpoint serum severe disease severity shown SOFA Soluble RAGE subsequent supplementary material Support syndrome therapy Variation was measured were measured with COVID-19 [DOI] 10.1186/s13613-021-00836-2 PMC 바로가기 [Article Type] Research
Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study중증 COVID-19 환자의 치명적인 결과 예측을 위한 노모그램: 다기관 연구Multicenter Study Published on 2021-03-172022-09-12 Journal: Military Medical Research [Category] 진단, [키워드] 95% CI Admission Analysis analyzed Blood C-reactive protein Chest computed tomography clinician Coagulation Cohort COVID-19 COVID-19 patient CRP death develop effective enrolled Factor help high risk hospital identify IL-6 IMPROVE independent indicated interleukin-6 Laboratory test Liver function Lymphocyte count Mortality multicenter multivariate nomogram observation outcome oxygen saturation Patient patients PCT predict prediction Probability procalcitonin Prognosis prognostic pulse receiving reduce renal function Result routine blood tests sensitivity serological severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients specificity supplementary material survival Tocilizumab treatment strategy validation cohort validation cohorts was measured [DOI] 10.1186/s40779-021-00315-6 PMC 바로가기 [Article Type] Multicenter Study
Space-time covid-19 Bayesian SIR modeling in South CarolinaResearch Article Published on 2021-03-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, SARS, [키워드] analyzed approach Asymptomatic Bayesian death deaths Effects examined ingredient lockdown New York pandemic prediction provided Region reported Repository South Spread time Transmission USA [DOI] 10.1371/journal.pone.0242777 PMC 바로가기 [Article Type] Research Article
Improving Predictions of COVID-19 Preventive Behavior: Development of a Sequential Mediation ModelOriginal Paper Published on 2021-03-172022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] appear asked Behavior belief Combination communication concerning COVID-19 COVID-19 pandemic Critical develop development driving explain Health healthy helping identify Improving increase individual information knowledge likelihood mediation mediation model Model modeling objective offered pandemic populations prediction prevention Preventive behavior preventive measure Qualtrics question rate of infection Result seeking Self-efficacy social distancing spread of COVID-19 student Support susceptible the disease variable was used washing hand wearing masks [DOI] 10.2196/23218 PMC 바로가기 [Article Type] Original Paper
Machine Learning Prediction of SARS-CoV-2 Polymerase Chain Reaction Results with Routine Blood Tests일상적인 혈액 검사를 통한 SARS-CoV-2 중합효소 연쇄 반응 결과의 기계 학습 예측Article Published on 2021-03-152022-09-11 Journal: Laboratory medicine [Category] SARS, 치료기술, [키워드] Accuracy Algorithm Analysis Blood blood tests chain Chain Reaction characteristic diagnosis of COVID-19 evaluated feature forest Laboratory machine machine learning Patient patients PCR test performed polymerase chain polymerase chain reaction predict prediction reaction receiver receiver operating characteristic Result retrospective cohort reverse transcription reverse transcription polymerase chain reaction routine routine blood test routine blood tests RT-PCR RT-PCR test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR test SARS-CoV-2 test SARS-CoV-2 testing Stool Test test result unique [DOI] 10.1093/labmed/lmaa111 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?SARS-CoV-2-토착 미생물총 넥서스: 장내 미생물총이 COVID-19의 염증 및 질병 중증도에 기여합니까?Cellular and Infection Microbiology Published on 2021-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 alteration approach Asymptomatic COVID-19 Cardiovascular disorders Clinical outcome co-morbidities comorbid condition contribute COVID-19 COVID-19 disease disease Dysbiosis effective Gut gut microbiome gut microbiota Host immune responses Immunopathogenesis Inflammation innate immune response Microbiome Microbiota (microorganism) morbidities novel obesity prebiotics prediction Probiotics profile SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection symptomatic T2D targeted intervention targeted interventions Therapeutic approach Therapeutic strategies [DOI] 10.3389/fcimb.2021.590874 PMC 바로가기 [Article Type] Cellular and Infection Microbiology