Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients—A Report of 10 CasesCase Series Published on 2021-03-122022-11-01 Journal: Case Reports in Nephrology [Category] COVID-19, [키워드] Analysis asymmetric baseline bilateral pneumonia Biomarker Blood carried Case series case sery Cellulose characteristic Course COVID-19 Diagnosis dialysis died disease drug effective evaluate favor hemodiafiltration Hemodialysis Hospital admission Hospitalization Hyperinflammatory IL-6 immunomodulatory effect Infection Inflammatory Inflammatory mediators less maintenance membrane membranes moderate outcome parameter Patient patients with SARS-CoV-2 Pneumonia positive predominant radiological reduce reduction in report required role SARS-CoV-2 severe pneumonia storm suggested susceptible systemic inflammation targeting tested the cytokine storm the disease the patient therapeutic therapeutic approaches therapeutic option those who survived variety [DOI] 10.1155/2021/5575928 PMC 바로가기 [Article Type] Case Series
The origin and early spread of SARS-CoV-2 in Europe유럽에서 SARS-CoV-2의 기원과 초기 확산Article Published on 2021-03-022022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, [키워드] Analysis China disease disease import estimated rate Europe European event Evidence geographic location Germany information Italy Lineage Local Migration Occurrence offer pandemic phylodynamic phylogeography predominant Region regions SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 pandemic Spread spring the epidemic the SARS-CoV-2 Timeliness Transmission viral genome sequence viral genome sequences virus [DOI] 10.1073/pnas.2012008118 PMC 바로가기 [Article Type] Article
ENT emergencies during the first wave of COVID-19 pandemic in Spain: Our experienceObservational Study Published on 2021-03-012022-10-05 Journal: American journal of otolaryngology [Category] 임상, [키워드] ambulatory Ambulatory care carried Characteristics confirmed case correlated correlation COVID-19 COVID-19 pandemic Critical decrease Department Emergency emergency medicine epidemiological situation explain First wave Generalized linear model Health health system Hospital administration Neck not affect otolaryngology predominant Primary Health Care reduction in remained Retrospective study SARS-CoV-2 SARS-CoV-2 pandemic Spanish surgery the SARS-CoV-2 university hospital [DOI] 10.1016/j.amjoto.2020.102865 PMC 바로가기 [Article Type] Observational Study
Development of new vaccine target against SARS-CoV2 using envelope (E) protein: An evolutionary, molecular modeling and docking based study외피(E) 단백질을 이용한 SARS-CoV2에 대한 새로운 백신 표적 개발: 진화, 분자 모델링 및 도킹 기반 연구Article Published on 2021-03-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 변종, [키워드] Analysis antigenic peptide antigenicity B-cell B-cell and T-cell epitopes cellular checked Consensus COVID-19 development Dissociation constant docking envelope epitope epitope identification Epitopes exploration H-bonds highest histocompatibility complex humans identify Interaction Interactions with MHCs. major histocompatibility complex MHC MHC-I MHC-II MHCs molecular Mutation pandemic peptides predominant Protein Protein conformation SARS-CoV2 SARS-CoV2 genome solvent surface protein T-cell epitopes the vaccine Vaccine Vaccine development Variability [DOI] 10.1016/j.ijbiomac.2020.12.192 PMC 바로가기 [Article Type] Article
Mutational spectra of SARS-CoV-2 orf1ab polyprotein and signature mutations in the United States of AmericaSARS-CoV-2 orf1ab 다단백질의 돌연변이 스펙트럼 및 미국의 시그니처 돌연변이Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] affected Alter America Amino acid amino acids Analysis analyzed antiviral therapeutics Asia calculated caused changes in Clustal Omega Comparative analysis Complete complex COVID-19 COVID-19 outbreak database death domain Europe followed by Helicase imperative in viral Infection Multiple Multiple sequence alignment Mutation mutational spectra NCBI nonstructural proteins ORF1 ORF1ab ORF1ab polyprotein pandemic pathogen Patient polyprotein polyproteins predicted predominant protein sequence Proteins replicase reported resulting RNA synthesis SARS-CoV-2 sequence Sequence alignment statistical significance the United State The United States unique United State United States United States of America Viral Viral RNA viral RNA synthesis virus [DOI] 10.1002/jmv.26417 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike D614G change enhances replication and transmission Research Published on 2021-02-262022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 airway angiotensin-converting enzyme 2 binding circulating COVID-19 Culture D614G D614G substitution ENhance epithelial Evolution of SARS-CoV-2 founder effect Human human ACE2 humans IMPROVE in vitro increases in nasal predominant Prevalence provide receptor reflect Replication SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant spike glycoprotein the SARS-CoV-2 Transmissibility Transmission variant virus [DOI] 10.1038/s41586-021-03361-1 [Article Type] Research
Early prediction model for progression and prognosis of severe patients with coronavirus disease 2019Observational Study Published on 2021-02-262022-10-04 Journal: Medicine [Category] 임상, [키워드] Admission age Analysis AUC characteristic Cohort coronavirus disease Coronavirus disease 2019 COVID-19 Critical cut-off value Decreased develop disease Disease progression elevated lactate dehydrogenase evaluate Health high-risk patient High-sensitivity C-reactive protein higher odd hsCRP Inpatient Intervention LDH Lymphocyte count male Odds ratio outcome Patient patients Predictive predominant Prognosis prognostic progressed progression recovered patient regression analysis Retrospective study risk risk factor ROC ROC analysis ROC Curve Sensitivity and specificity severe COVID-19 Severe patient the mean validation cohort were used with COVID-19 [DOI] 10.1097/MD.0000000000024901 PMC 바로가기 [Article Type] Observational Study
Distinguishing active pediatric COVID-19 pneumonia from MIS-CResearch Article Published on 2021-02-242022-10-29 Journal: Pediatric Rheumatology Online Journal [Category] COVID-19, MERS, [키워드] Accuracy Admission baseline black C-reactive protein center change Characteristics clinical note Control COVID-19 COVID-19 patient COVID-19 patients defined demographics diagnosed Diagnosis diagnostic disease distinguishing electronic medical record erythrocyte sedimentation rate finding Gastrointestinal symptom group health-care healthy Hispanic patient Hospitalized Importance Laboratory laboratory data lactate dehydrogenase male Mild MIS-C Moderate COVID-19 MOST objective Patient PCR pediatric Pneumonia positive predominant presenting procalcitonin prodrome Rash Respiratory Support respiratory symptoms SAR-CoV-2 severe COVID-19 significant difference sodium levels Symptom symptomatic Symptoms the SARS-CoV-2 virus Treatment treatment protocols two group [DOI] 10.1186/s12969-021-00508-2 PMC 바로가기 [Article Type] Research Article
Quarantine due to the COVID-19 pandemic from the perspective of adolescents: the crucial role of technologyResearch Published on 2021-02-222022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, MERS, [키워드] activity Adolescence affected Anxiety approach behavioural response change collected conducted country COVID-19 COVID-19 pandemic demographic characteristics Lock-down MOST outbreak pandemic participant Personal protective equipment Perspective physical activity predominant psychological Impact quarantine reported Resilience Result SARS-CoV-2 School Schools Self-isolation social distancing social media subject supplementary material swabs technology [DOI] 10.1186/s13052-021-00997-7 PMC 바로가기 [Article Type] Research
Distinct antibody repertoires against endemic human coronaviruses in children and adultsResearch Article Published on 2021-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] Acidic Acute respiratory infection antibody antibody repertoire Antibody Response B cell epitopes B cell response children Cohort comprehensive analysis conserved Coronavirus infection Coronaviruses cross-reactive dominant donors endemic HCoV endemic human coronavirus Epidemic fusion peptide HCoV-HKU1 human antibody response humans IgG immunoglobulins immunology immunoprecipitation Infectious disease linear monoclonal antibody N-terminal nucleocapsid peptide polyprotein predominant Prophylactic Proteins ranged Region S2′ cleavage Sequencing Seroprevalence specificity the spike protein therapeutic Vaccine design virus [DOI] 10.1172/jci.insight.144499 PMC 바로가기 [Article Type] Research Article