Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients사르데냐 다발성 경화증 환자에서 BNT162b2 백신에 대한 체액 반응에 대한 다양한 질병 수정 요법의 효과Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] Acetate addition affected age Alemtuzumab analyzed anti-SARS-CoV-2 vaccine Antibody titer Antibody titers BNT162b2 BNT162b2 vaccine Clinical data clinically COVID-19 COVID-19 vaccine demographic difference dimethyl fumarate Disease-modifying therapy drug Effect Factor fingolimod followed by fumarate Glatiramer healthy control humoral immune response Humoral immunity Humoral response immune response infected with SARS-CoV-2 interferon investigated linear Male sex mixed-effects model mRNA mRNA-based Multiple multiple sclerosis objective observé of BNT162b2 Older age Patient patients patients treated Prevent response Result Sardinian SARS-CoV-2 SARS-COV-2 infection sclerosis second dose sera serology Sex significantly significantly higher significantly lower smoking smoking status statistically significant difference Teriflunomide tested therapy Treatment treatment group treatment groups uninfected untreated patients vaccination Vaccine vaccine efficacy were assessed [DOI] 10.3389/fimmu.2021.781843 PMC 바로가기 [Article Type] Immunology
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together밤라니비맙 단독 또는 밤라니비맙과 에테세비맙을 함께 투여받은 경증 또는 중등도 COVID-19 환자에서 SARS-CoV-2에 대한 내인성 항체 반응Clinical Trial Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 임상, 진단, 치료법, 치료제, [키워드] Administered antibodies Antibody Response Antibody titer Antibody titers antigenic B.1.351 bamlanivimab baseline Beta Beta variant binding breadth clinically Cohort collected correlated COVID-19 Day decrease develop domain Effect endogenous epitope Epitopes etesevimab evade Factor full-length Hospitalization humoral immune response in viral investigated longitudinal mAb mAbs Mild Moderate COVID-19 monoclonal antibody monotherapy Mortality multiplex mutant N-terminal domain Neutralization assay Neutralizing activity neutralizing monoclonal antibodies nucleocapsid protein Patient performed Placebo Received receiving recipient reduced reductions in response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 pseudovirus sera serology serum sample specificity subsequent titer titers treated Treatment Trial variant Viral Viral load [DOI] 10.3389/fimmu.2021.790469 PMC 바로가기 [Article Type] Clinical Trial
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targetsArticle Published on 2021-12-092022-10-04 Journal: Nature cell biology [Category] 바이오마커, [키워드] ACE ACE2 Ago2 Alzheimer’s disease app Biomarker Cancer Cancer models cardiovascular disease Cell Biology Cellular imaging circulating clinically decrease disease Diseases Enzymes Extracellular extracellular vesicle functional GPC1 greater hepatic lipid Host human diseases identify in vivo intense investigation involved Lactate majority mass spectrometry MET morphologically PCSK9 prognostic Protein RNA secretion TGFBI therapeutic therapeutic target transfer unique Vesicle [DOI] 10.1038/s41556-021-00805-8 PMC 바로가기 [Article Type] Article
PAD Inhibitors as a Potential Treatment for SARS-CoV-2 ImmunothrombosisReview Published on 2021-12-092022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome arginine residue citrullinated histones clinically connection coronavirus COVID-19 COVID-19 patients Critical Efficacy enzyme Evolution extracellular trap immunothrombosis inflammatory disease inflammatory disorder inhibitor inhibitors involved linear manifestation Modification mutant strain NET NETs offer PAD pathophysiology Potential reducing researcher SARS-CoV-2 SARS-CoV2 thrombotic thrombotic complication treat Vaccine variant variants [DOI] 10.3390/biomedicines9121867 PMC 바로가기 [Article Type] Review
Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort StudyPublic Health Published on 2021-12-072022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] abnormality affecting Analysis approved autoimmune condition cancers chest X-ray clinically cohort study Committee conducted connective tissue COVID 19 COVID-19 declined determine Diagnosis diffusion discharge disease disorders DLCO Effect ERC Evidence excluded function help hospital Impact indicated initial Interstitial lung disease Karachi limitation Long long-term impact lung lung capacity Lung fibrosis Lung function Lungs moderate nasopharyngeal Obstructive Oropharyngeal overcome Patient per day performed positive Prospective prospective cohort study pulmonary pulmonary hypertension reference number repeated review RT-PCR severe COVID-19 severe COVID-19 disease severe disease single-center spirometry statistical strength survived survivor Survivors Syncope term the disease university [DOI] 10.3389/fpubh.2021.663076 PMC 바로가기 [Article Type] Public Health
Physician’s Burnout and the COVID-19 Pandemic—A Nationwide Cross-Sectional Study in AustriaPsychiatry Published on 2021-12-072022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Analysis being BSI-18 Burnout clinically comparable COVID-19 COVID-19 pandemic demographic data evaluate Evidence Factor Factors General practitioners group high risk hospital inventory material outcome pandemic Patient care physician Physicians Practitioner predicted predictor Prevalence problem proportion provided Psychological distress questionnaire Registered response SARS-CoV-2-positive patient statistical significance Stress study participant Treatment variable was used were assessed [DOI] 10.3389/fpsyt.2021.784131 PMC 바로가기 [Article Type] Psychiatry
Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture modelsArticle Published on 2021-12-062022-10-04 Journal: Scientific Reports [Category] 변종, 신약개발, 치료제, [키워드] 3D structure Affect anti-SARS-CoV-2 Antiviral binding affinity Cell culture children clinically Comparative coronavirus cytokine docking Drug discovery drugs Effects Evidence Favipiravir HCoV-NL63 higher affinity Human Immunocompromised patients indicated Infection infectious viruses inhibited inhibiting interferon-alpha Microbiology molecular docking morbidity and mortality NL63 patients provided RdRP Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp significantly specific treatment subset synergistic viral replication [DOI] 10.1038/s41598-021-02972-y PMC 바로가기 [Article Type] Article
Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A cohort study미국과 페루에서 SARS-CoV-2 감염에서 회복된 인구통계학적 및 임상적으로 다양한 개인에서 시간이 지남에 따라 항체 반응 중화: 코호트 연구Research Article Published on 2021-12-062022-09-12 Journal: PLoS Medicine [Category] 진단, [키워드] 293T/ACE2 cells acute respiratory syndrome coronavirus age age and sex analyses Analysis antibody Antibody Response applied assigned association Asymptomatic Birth Blood body mass body mass index Clinical characteristics clinical manifestations Clinical outcome clinical outcomes clinically Cohort cohort study collected Comorbidities Comorbidity convalescent convalescent individual convalescent individuals coronavirus 2 coronavirus disease Coronavirus disease 2019 correlation COVID-19 death declined demographic and clinical characteristics Demographic variables demographics diabete diabetes disease onset disease severity enrolled Factors help heterogeneity highlighting Hispanic hypertension identify immune defense immune response immune responses Immunity implementation in some include individual Infection limitation Linear regression Male sex medical history mild illness Multiple Multiple linear regression NAb NAb responses NAb titers NAbs nasal samples natural history Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses not differ observation participant peaked Protective pulmonary disease Questionnaires researcher respiratory response responses SARS-CoV-2 SARS-CoV-2 antibody response SARS-COV-2 infection SARS-CoV-2 spike protein serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease Sex smoking Spike protein survivorship the United State therapeutic strategy Therapeutics thought titers to define Treatment Trial registration United States Vaccine Variation variety Viral load virus virus infection were measured white [DOI] 10.1371/journal.pmed.1003868 PMC 바로가기 [Article Type] Research Article
Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptomsResearch article Published on 2021-12-052022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] affective Analysis auditory breathlessness clinical examination clinically cognitive Cognitive function Cognitive impairment Cohort cohort study complexity concerning Consequences COVID-19 detrimental fatigue finding FIVE Follow-up form functional healthcare hospital hospitalised patient hospitalized COVID-19 patient individual Intervention Linköping Long-term follow-up nonspecific Östergötland PACS Pain Patient performed post-COVID-19 primary care problem provided Region regions rehabilitation Rehabilitation need reported required Residual symptoms SARS-CoV-2 self-reported symptom survivor Swedish Symptom Symptoms translated weakness were assessed [DOI] 10.1016/j.eclinm.2021.101219 [Article Type] Research article
Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A ReviewNano Review Published on 2021-12-052022-10-30 Journal: Nanoscale Research Letters [Category] COVID-19, [키워드] anticancer approval approved AuNP benefit Bio-functionalization can be used clinical trial clinical trials clinically Combination disease Disease diagnosis drug drug delivery drug targeting Efficacy FDA food gold Gold nanoparticles Health IMPROVE Improved Infection Metal-based therapy Multimodal systems nanoparticle offer reduced review shown the United State therapeutic therapy threat Treatment unique variety [DOI] 10.1186/s11671-021-03632-w PMC 바로가기 [Article Type] Nano Review