Drug repurposing – Page 39 – Communicable Diseases Research

Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection

Molecular Biosciences

Published on 2021-02-262022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE-2 activity addition Angiotensin converting enzyme-2 applied approach approved bictegravir binding binding affinity binding free energy binding interaction Carfilzomib carried clinically computational tool coronavirus costly COVID-19 determine develop disease drug drug candidate Drug discovery Drug repurposing Effectiveness FDA Health Organization help homology identify increase infect Infection information inhibitor Interaction involved lung methodology molecular molecular docking nelfinavir novel occur outbreak pandemic performed pharmacokinetic pharmacological Potential Prulifloxacin receptor reducing reported repurposing Respiratory system respiratory tract risk similarity Spike protein Strategy switching target protein Tegobuvir therapeutic therapeutic agent therapeutic agents Therapeutics three group time-consuming Treatment Viral proteins Virtual screening
[DOI] 10.3389/fmolb.2021.628144 PMC 바로가기 [Article Type] Molecular Biosciences

Repurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations

Research article

Published on 2021-02-252022-10-05
Journal: Informatics in Medicine Unlocked [Category] 신약개발, 치료제,

Drug Repurposing in the COVID-19 Era: Insights from Case Studies Showing Pharmaceutical Peculiarities

Review

Published on 2021-02-252022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Drug Repurposing and Polypharmacology to Fight SARS-CoV-2 Through Inhibition of the Main Protease

Pharmacology

Published on 2021-02-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Action of Dipeptidyl Peptidase‐4 Inhibitors on SARS‐CoV‐2 Main Protease

Communication

Published on 2021-02-172022-10-31
Journal: ChemMedChem [Category] COVID-19, SARS,

[키워드] Action analogue Analysis approved binding blocked catalytic activity COVID‐19 COVID19 docking DPP-4 drug candidate Drug repurposing enzymatic assay functional inactive inhibitor inhibitors linagliptin M pro main protease (M^pro) pandemic protease SARS-CoV-2 SARS‐CoV‐2 suggested
[DOI] 10.1002/cmdc.202000921 PMC 바로가기 [Article Type] Communication

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

Article

Published on 2021-02-172022-10-28
Journal: Viruses [Category] COVID-19, MERS,

[키워드] Activation alleviate blocking candidate catalytic activity caused complement conducted Consequences conserved contribute Coronaviral coronavirus Coronavirus infections Coronaviruses drug Drug repurposing enzyme human coronavirus Hyperactivation in silico in vitro in vivo Infection inhibitor inhibitory activity Interaction lectin pathway lung Lung injury MASP-2 MERS-CoV Molecular modelling monoclonal antibody N proteins nucleocapsid patients Prevent Protein protein-protein interaction Proteins reduce mortality rate SARS-CoV SARS-CoV-2 screened selected serine protease severe complication Strategy Support targeting tested Treatment triggered
[DOI] 10.3390/v13020312 PMC 바로가기 [Article Type] Article

Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing

약물 용도 변경 후보를 식별하기 위한 SARS-CoV-2 발현 및 노화의 인과 관계 네트워크 모델

Article

Published on 2021-02-152022-08-31
Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] Analysis approach approved drug candidate candidate drugs Causal clinical trial clinical trials Critical Data integration data-driven Diseases Drug discovery Drug repurposing expression Gene regulatory networks High-throughput screening highlight identify in vitro experiment kinase kinases lung lung epithelium machine learning pandemic pathogenicity Pathways platform Protein target protein targets proteomic RNA-seq data robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Serine severity suggested target the SARS-CoV-2 threonine transcriptional transcriptomic tyrosine Virtual drug screening while
[DOI] 10.1038/s41467-021-21056-z PMC 바로가기 [Article Type] Article

Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19

약물, 대사 산물 및 폐 축적 작은 Lysosomotropic 분자: 다중 표적은 SARS-CoV-2 감염 및 COVID-19로의 진행을 방해합니다

Hypothesis

Published on 2021-02-112022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approved drug approved drugs Bacterial biological characteristic candidate cathepsin cathepsin L cathepsin L-dependent characteristic Chloroquine compounds condition coronavirus coronavirus disease COVID-19 CRS cytokine Cytokine release syndrome Cytokine storm disease drug Drug repurposing drugs Effects eligibility criteria endothelial enrichment heterogeneous group host cells hydroxy Hypothesis IL-6 Inflammatory intrinsic lysosomal enzyme lysosomal enzymes lysosome Lysosomes lysosomotropism metabolite metabolites Multiple OTC pandemic Patient pharmacological profile Progress Prophylaxis pulmonary tissue pulmonary tissue accumulation receiving respiratory SARS-CoV-2 SARS-COV-2 infection second messengers severe acute respiratory syndrome Coronavirus Small molecules Stress stress response systemic inflammation targeting targets tissue transition Treatment triggered Viral viral entry viral host cell entry viral infections
[DOI] 10.3390/ijms22041797 PMC 바로가기 [Article Type] Hypothesis

Identification of potential antivirals against SARS-CoV-2 using virtual screening method

Research article

Published on 2021-02-102022-10-05
Journal: Informatics in Medicine Unlocked [Category] 신약개발, 치료제,

A Transcription Regulatory Sequence in the 5′ Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs

SARS-CoV-2의 5' 비번역 영역의 전사 조절 서열은 인간 억제 MicroRNA에 대한 변경된 진화 패턴을 가진 바이러스 복제에 중요합니다

Article

Published on 2021-02-042022-09-11
Journal: Cells [Category] MERS, 변종, 신약개발,