Machine learning to support visual auditing of home-based lateral flow immunoassay self-test results for SARS-CoV-2 antibodies Research Published on 2022-07-062022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] Accuracy Algorithm Analysis antibody Antigen automated Blood Cohen’s kappa Community COVID-19 datasets detect England false negatives False positive false-negative False-positive Flow IgG IgG test immunoassay IMPROVE Interpretation Lateral lateral flow immunoassay Lateral flow test LFIA LFIAs machine performed positive Prevalence prevalence study REACT-2 reducing reported Result risk SARS-CoV-2 antibody sensitivity Sensitivity and specificity Study participants Support Surveillance test line toolkit [DOI] 10.1038/s43856-022-00146-z [Article Type] Research
Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다Observational Study Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination Vaccine vector was used were measured were recorded [DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus diseaseI형 인터페론에 대한 자가항체를 중화하는 중환자 COVID-19 환자는 헤르페스 바이러스 질병의 위험이 증가했습니다Article Published on 2022-07-052022-09-12 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval age Analysis anatomical antiviral action autoantibodies autoantibody caused clinical outcomes CMV Cohort coronavirus 2 COVID-19 COVID-19 cohort COVID-19 patient Critically ill critically ill patients deficiency early diagnosis exacerbate Gender healthy donors herpes simplex herpesvirus disease herpesviruses heterogeneity Hospitalization ICU IFN IFNs IgA IgG IgG level IgM increased risk Infection intensive care likelihood longitudinal Neutralizing Odds ratio one patient Patient plasma predict predisposition respiratory SARS-CoV-2 screened steroid treatment Stratification suffered Switzerland tested tracheobronchial secretions Treatment type I interferon virus [DOI] 10.1371/journal.pbio.3001709 PMC 바로가기 [Article Type] Article
Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switchSARS-CoV-2에 대한 단일 클론 인간 IgM에 의한 강력한 중화는 클래스 전환에 의해 손상됩니다Article Published on 2022-07-052022-09-12 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Anti-viral antibodies antibody Antigen B cell B cells binding cell sorting class switch concentrations Donor expected explain human cells IgA IgG IgM IgM antibodies infected with SARS-CoV-2 MACACS membrane membrane antigen. monoclonal neutralization parents potent SARS-CoV-2 the antibody Virus neutralization [DOI] 10.15252/embr.202153956 PMC 바로가기 [Article Type] Article
Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals비활성화된 COVID-19 백신에 대한 면역 반응 및 안전성: HIV 감염자와 HIV 감염 경험이 없는 개인 간의 비교Article Published on 2022-07-052022-09-12 Journal: AIDS Research and Therapy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI Adults Adverse reaction Antibody neutralization Antiretroviral therapy baseline binding antibody unit Biological CD4 chemiluminescence colloidal gold COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy ELISA enrolled Follow-up Frequency geometric geometric mean concentration GMC humoral immune response IgG IgG antibody IgG response immune immune response inactivated Inactivated COVID-19 vaccine individual injection NAb not different observation outcome peaked PLWH PLWH population PLWH. primary immunogenicity product remained response SARS-CoV-2 neutralizing antibody second dose Serious Adverse Events seroconversion rate shown Sinopharm specific IgM with HIV Wuhan [DOI] 10.1186/s12981-022-00459-y PMC 바로가기 [Article Type] Article
Do the Kinetics of Antibody Responses Predict Clinical Outcome in Hospitalized Patients With Moderate-to-Severe COVID-19?항체 반응의 역학은 중등도에서 중증의 COVID-19로 입원한 환자의 임상 결과를 예측합니까?Observational Study Published on 2022-07-012022-09-11 Journal: In vivo (Athens, Greece) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody kinetics Antibody Response Antibody responses association Chain Reaction clinical Clinical deterioration Clinical outcome clinical outcomes clinical risk factor Complication consecutive patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 infection COVID-19-related complication COVID-19-related complications diabetes diagnosed discharged dyslipidemia follow-up period Hospitalization Hospitalized hospitalized patient hospitalized patients hospitals IgG IgG positivity IgM Immunoglobulin Immunoglobulin G immunoglobulin M Infection intensive care unit Intubated Kinetics Logistic regression analysis males median median age median time moderate-to-severe COVID-19 observational study onset of symptoms Patient patients died polymerase chain polymerase chain reaction predict Predictive prospective observational study qualitative detection Rapid Rapid test respiratory response SARS-CoV-2 SARS-CoV-2 antibody Seroconversion serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity symptomatic time interval time intervals Univariate logistic regression analysis was performed with COVID-19 [DOI] 10.21873/invivo.12916 PMC 바로가기 [Article Type] Observational Study
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T-세포 검출을 위한 T-세포 증식 분석Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] an area Analysis antibody approved AUC B-cell B-cell response blood sample Blood samples carried cellular cellular immune responses clinical setting clinical settings complex Control control group controls ELISA assay False positive False positives Health care Health care worker health care workers humoral Humoral and cellular immune responses IgG immune immune responses Immunoglobulin Immunoglobulin G Infection less lymphocyte lymphocyte transformation Lymphocyte transformation test majority membrane N and M non-infected nucleocapsid peptide peptide pool peptide pools proliferation Protein representing resulting ROC analysis S protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Stimulation T-cell T-cell Response T-cell responses the S protein the S1 subunit the SARS-CoV-2 thymidine Trigger vaccinated individual vaccination Vaccines were recorded [DOI] 10.1016/j.cca.2022.05.025 PMC 바로가기 [Article Type] Article
Inactivated SARS-CoV-2 vaccine in primary Sjögren’s syndrome: humoral response, safety, and effects on disease activity원발성 쇼그렌 증후군에서 비활성화된 SARS-CoV-2 백신: 체액 반응, 안전성 및 질병 활동에 대한 영향Clinical Trial Published on 2022-07-012022-09-12 Journal: Clinical Rheumatology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI activity Adverse age anti-SARS-CoV-2 autoantibody Autoimmune disease booster dose comparable Control controls COVID-19 Deleterious detrimental Disease activity dose Effect event female Frequency geometric mean titer GMT humoral IgG immunogenicity index IQR Mild moderate Neutralizing activity neutralizing antibody participant Patient patients Point S1/S2 Safe Safety SARS-CoV-2 SARS-CoV-2 vaccine Seroconversion Sex Sjögren’s syndrome syndrome Trial Vaccine were assessed [DOI] 10.1007/s10067-022-06134-x PMC 바로가기 [Article Type] Clinical Trial
Age and vitamin D affect the magnitude of the antibody response to the first dose of the SARS-CoV-2 BNT162b2 vaccine나이와 비타민 D는 SARS-CoV-2 BNT162b2 백신의 첫 번째 접종에 대한 항체 반응의 크기에 영향을 미칩니다Article Published on 2022-07-012022-09-12 Journal: Current research in translational medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abbott Diagnostics Affect affected age approved average baseline blood sample BNT162b2 BNT162b2 vaccine collected Concentration decrease dose Final first dose greater group HCW healthcare worker highest IgG immunization individual magnitude MOST of BNT162b2 Patient peak peak concentration peaked positive produced provided receive receiving remained response SARS-CoV-2 significant effect significantly spike Support the antibody response the SARS-CoV-2 UK Government Vaccine Vitamin Vitamin D Vitamin D status was measured was performed younger subject [DOI] 10.1016/j.retram.2022.103344 PMC 바로가기 [Article Type] Article
A case report of breakthrough infection with the SARS-CoV-2 delta variant and household transmission: Role of vaccination, anti-spike IgG and neutralizing activitySARS-CoV-2 델타 변이형 돌발성 감염 및 가정전파 증례: 백신의 역할, 스파이크 방지 IgG 및 중화 활성Case Reports Published on 2022-07-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-Spike IgG Antibody titers BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Case report Clinical course clinical symptom contribute coronavirus defined Delta delta variant dose female Fever gradually increased healthcare worker IgG Immunoglobulin Immunoglobulin G index case individual individuals Infection Neutralizing activity Neutralizing antibodies neutralizing antibody occur patients remained respiratory role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody secondary case severe acute respiratory syndrome Coronavirus the SARS-CoV-2 vaccinated individual vaccinated individuals vaccination Vaccine variant [DOI] 10.1016/j.jiac.2022.02.003 PMC 바로가기 [Article Type] Case Reports