Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areasReview Article Published on 2021-05-292022-10-31 Journal: Environmental science and pollution research inter [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Air pollution article Coagulation coronavirus COVID-19 COVID-19 outbreak Critical disease Effect Environmental marker Epidemic Health Health marker help humans impacted IMPROVE indicated Infection Inflammation knowledge mortality rate observation outbreak oxidative stress Pathogens predict produced producing Research risk SARS-CoV-2 Semen Semen quality sensitivity Spread susceptibility the SARS-CoV-2 Topic variety virus virus transmission viruses [DOI] 10.1007/s11356-021-14579-x PMC 바로가기 [Article Type] Review Article
Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian CellsReview Published on 2021-05-282022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activate addition Affect amplify autophagy Bacteria cell death Defense described Effect Endoplasmic reticulum ER stress Host immune induce Infection Inflammation Innate immunity Interaction Intracellular mechanism mechanisms microbial Mitochondria oxidative stress pathogen Pathogens reactive oxygen specy regulate Regulation Reticulum ROS ROS production Specy Stress [DOI] 10.3390/antiox10060872 PMC 바로가기 [Article Type] Review
The Immunological Role of the Placenta in SARS-CoV-2 Infection—Viral Transmission, Immune Regulation, and Lactoferrin ActivityReview Published on 2021-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activity acute respiratory infections anti-viral activity complications consequence coronavirus Course COVID-19 epidemiological Evidence expression feature fluids groups increase in Infection knowledge lactoferrin mother’s placenta neonatal tissue offspring oxidative stress pandemic pandemic virus Particles pathogenicity pathology placental potential transmission pregnant women Premature Proteases receptor respiratory role SARS-CoV-2 spontaneous abortion Stillbirth Transmission viral infection virus [DOI] 10.3390/ijms22115799 PMC 바로가기 [Article Type] Review
Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural AntioxidantsCellular and Infection Microbiology Published on 2021-05-262022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] activating airways antioxidant antioxidants being binding condition conformational change contribute COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 severity dendritic cell disease Disease progression host cell Impact in viral Inflammation innate immune system involved Macrophage mechanism metabolic natural occur oxidative stress Pathogenesis Potential Process public health redox status required Research respond SARS-CoV-2 signaling pathways Stress Therapeutic strategies Therapeutics therapy Trial unique viral replication virus zoonotic disease [DOI] 10.3389/fcimb.2021.654813 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Estimates of gene ensemble noise highlight critical pathways and predict disease severity in H1N1, COVID-19 and mortality in sepsis patients유전자 앙상블 노이즈 추정치는 중요한 경로를 강조하고 H1N1, COVID-19의 질병 중증도 및 패혈증 환자의 사망률 예측Article Published on 2021-05-242022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] alteration among others Analysis approach bioinformatics biological pathway Biomarker calculated changes Clinical outcome clinical outcomes Complex I COVID-19 Critical Differential gene expression differential gene expression analysis disease disease severity disease-associated dissect estimate expression of gene finding Gene Expression Gene expression analysis gene network gene networks genes encoding H1N1 hallmark heterogeneous highlight immune include individual inter-individual Interpretation measure mitochondrial molecular molecular mechanism molecular mechanisms Mortality oxidative stress pathology pathway Pathways Patient patients peroxisomes predict Predictive markers Prism Prognostic markers protein complex protein complexes reflected respiratory chain Respiratory system models response Sepsis sepsis patient sepsis patients subunit subunits Variability variance [DOI] 10.1038/s41598-021-90192-9 PMC 바로가기 [Article Type] Article
The Molecular Basis of COVID-19 Pathogenesis, Conventional and Nanomedicine TherapyCOVID-19 병인의 분자적 기초, 기존 및 나노의학 요법Review Published on 2021-05-212022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] accompanied activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus ADP-ribose angiotensin Angiotensin II Apoptosis Basis blocker blockers Cell cell death clinical manifestation clinical manifestations Conventional Coronaviridae family coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 pathogenesis cytokine Cytokine storm develop DNA damage Endothelial dysfunction explained Health Organization highly pathogenic humans infect inhibiting investigated involved iron iron oxides losartan macrodomain mechanism mefenamic acid MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular mechanisms morbidity morbidity and mortality nanomedicine Necrosis non-structural protein outbreak oxidative burst oxidative stress pandemic PARG PARP pathogenic virus Potential potential therapeutic targets protein 3 quantum dots RAS RAS pathway receptor receptor potential Renin renin-angiotensin system respiratory respiratory distress Respiratory distress syndrome respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway Spread syndrome tannins the Coronaviridae therapeutic agent therapeutic agents therapeutic targets thought trehalose TRPM2 Viral virus virus entry Vitamin D3 World Health Organization [DOI] 10.3390/ijms22115438 PMC 바로가기 [Article Type] Review
Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic CandidatesSARS-CoV-2의 다중 신호 전달 경로 표적화: COVID-19 치료 후보에 대한 접근Review Published on 2021-05-142022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] Acute coronary syndrome Apoptosis autophagy candidate Candidates Caspases clinical symptom Clinical symptoms combating coronary syndrome coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop effective Epidemics Factor highlight Host Inflammation Interaction lung failure mediators Multiple natural products Necrosis Nrf2 nuclear oxidative stress pathogenic pathway Pneumonia remained Replication road SARS-CoV-2 signal signaling pathway signaling pathways targeting therapeutic target therapy TNF-α transduction Treatment strategies Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α [DOI] 10.3390/molecules26102917 PMC 바로가기 [Article Type] Review
Vaping, SARS-CoV-2, and Multisystem Inflammatory Syndrome: A Perfect StormPediatrics Published on 2021-05-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] ACE ACE2 ACE2 receptors acute respiratory distress alteration ARDS association characterized children clearance consequence COVID-19 Defense develop disease Electronic cigarette EVALI fibrosis Health highlight immune system Impact Inflammation Inflammatory MIS-C morbidities Multisystem inflammatory syndrome oxidative stress pandemic peribronchial plethora Protective receptor respiratory symptom resulting risk SARS-CoV-2 shown storm syndrome target unique upregulation vaping vaping-associated lung injury virus [DOI] 10.3389/fped.2021.647925 PMC 바로가기 [Article Type] Pediatrics
Alteration in the Lipid Profile and the Desaturases Activity in Patients With Severe Pneumonia by SARS-CoV-2Physiology Published on 2021-05-112022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] activity acute respiratory syndrome Alter alteration Apoptosis arachidonic acid caused Cell cell membranes change changes in characterized cholesterol COVID-19 COVID-19 patients cytokine release decrease Defense elevated EPA evaluated fatty Fatty acid fatty acids favor HDL Host host cell metabolism host’s cell include increase in inflammatory process LDL Lipid lipid metabolism membrane metabolism mitochondrial membrane modulate Necrosis NEFA NEFAs oxidative stress participated Patient phospholipid Phospholipids plasma Pneumonia profile profiles provided Replication SARS-CoV-2 severe pneumonia Triglyceride Variation viral membrane virus [DOI] 10.3389/fphys.2021.667024 PMC 바로가기 [Article Type] Physiology
Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical OutcomesReview Published on 2021-05-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] “cytokine storm” ACE2 Activation acute respiratory syndrome adaptive Adverse Alpha association binding characterized chronic inflammation clinical clinical study cohorts Combination contribute coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis cytokine demonstrated determine diabete Diabetes Mellitus Diabetic disease severity elevated endothelial Endothelial cell Endothelial dysfunction enzyme extreme Glucose hyperglycemia IL-1β IL-2 IL-6 Immunity Impaired impairment Infection Inflammation life-threatening COVID-19 disease Major morbidity and mortality multi-organ failure Necrosis outcome outcomes oxidative stress pancreatic Pathogenesis pathway Patient PKC pro-inflammatory cytokines Protein recent receptor required risk factor SARS-CoV-2 the SARS-CoV-2 TNF-α turn Type Type 1 diabetes mellitus vaccination [DOI] 10.3390/antiox10050752 PMC 바로가기 [Article Type] Review