A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoVVaccines and Antiviral Agents Published on 2018-06-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activity antibody Antiviral antiviral therapeutics binding binding site C-terminal clearance conformational conserved Critical cross-neutralization cross-neutralize cross-neutralizing domain Efficacy epitope Epitopes exhibited expressed expression feasibility high affinity Human humanized in vivo infect Infection mapped MERS-CoV MERS-CoV infection MERS-CoV RBD mice Middle East nanobody Neutralizing novel potent potential limitation produced producing Prophylactic PROTECT protective efficacy RBD receptor Receptor-binding domain recognizing renal residue respiratory respiratory syndrome coronavirus significantly Spike protein Spread strain targeting tested the RBD the receptor-binding domain therapeutic agents therapeutic efficacy Treatment yeast [DOI] 10.1128/JVI.00837-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
The impact of a mosquito net voucher subsidy programme on incremental ownership: The case of the Tanzania National Voucher Schemearticle Published on 2018-03-312024-09-01 Journal: Health Economics [Category] 말라리아, [키워드] malaria Subsidies Tanzania targeting vouchers [Article Type] article
microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro *Research Published on 2018-02-072022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus, [키워드] Accessory activating Activation addition adopted aggravate Analysis Cell damage demonstrated diarrhea differentially expressed downregulated Effect elevated expression IL1RAP Infection interleukin-1 investigated kidney MAPK mitochondrial Mitochondrial function mitochondrial membrane potential p38 MAPK signaling pathway PK-15 positive previous study Protein proteomic Quantitative RB1 receptor reduced Regulatory retinoblastoma suppressed target targeting TGEV transmissible gastroenteritis virus upregulated Via [DOI] 10.1074/mcp.RA117.000432 PMC 바로가기 [Article Type] Research
Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 DomainsArticle Published on 2018-02-062022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Administered Antiviral cell-cell fusion coronavirus 229E domains effective fusion HCoV-229E heptad repeat Human Immunocompromised patient Infants Infection inhibit inhibited inhibitor intranasally Lower respiratory tract maintain membrane fusion peptide peptide-based pseudotyped reported Safe severe disease spike Spike protein targeting treat Treatment [DOI] 10.3390/ijms19020487 PMC 바로가기 [Article Type] Article
Household beliefs about malaria testing and treatment in Western Kenya: the role of health worker adherence to malaria test results서부 케냐의 말라리아 검사 및 치료에 대한 가정의 신념: 말라리아 검사 결과에 대한 건강 관리자의 준수 역할Research Published on 2017-08-222024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Artemisinin-combination therapy Case management Household beliefs malaria Rapid diagnostic tests targeting Treatment-seeking behavior [DOI] 10.1186/s12936-017-1993-7 PMC 바로가기 [Article Type] Research
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral ActivityArticle Published on 2017-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activities activity approach block cells cellular combination treatment Compound Comprehensive Coronaviral Coronaviruses dominant effective feasible host cell Infection inhibit inhibition inhibitor IκBα Jak JAK2 mechanisms Mediated MERS-CoV NF-κB NF-κB activation p65 pathway Pathways Phosphorylation pro-inflammatory response Regulation Replication SARS-CoV target targeting TGEV Treatment viral infection Viral RNA virus [DOI] 10.1038/s41598-017-04203-9 PMC 바로가기 [Article Type] Article
miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1Microbiology Published on 2017-05-032022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] cause caused Central nervous system CNS Control cortical demonstrated dendritic disease disrupting dysfunction Encephalomyelitis functional Host increased survival Infection inhibitor Injury mice microenvironment microRNA miR-142-5p morphogenesis mRNA neurodegeneration neurodegenerative neurological Neuron neuronal neuronal morphogenesis neurotropic virus PHE phenotype porcine hemagglutinating encephalomyelitis virus provided regulate Relieving significantly spatiotemporal targeting Ulk1 viral replication virus [DOI] 10.3389/fcimb.2017.00155 PMC 바로가기 [Article Type] Microbiology
Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic OriginsArticle Published on 2015-03-122022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 2G12 activities activity acute respiratory syndrome AGOR analyses Antigen antigens ASOR carbohydrate carbohydrate microarrays characterized conserved coronavirus epitope Epitopes Express Galanthus genomic GlcNAc glycan glycosylation GNA HCMV high-density highlight HIV-1 Host Human Cytomegalovirus Human monoclonal antibody identifying include information Man Microarray moiety molecular basis molecular target neutralize oligomannoses origin Phylogenetic probes profile Progress Protein target reactive recognize SARS-CoV sugar moieties sugar moiety target targeting Vaccine viral pathogens virus Virus neutralization virus-neutralizing virus-neutralizing antibody [DOI] 10.3390/molecules20034610 PMC 바로가기 [Article Type] Article
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusResearch Article Published on 2014-05-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] accompanied accumulating antiviral activity antiviral drug antiviral intervention cellular membrane complex component Compound concerning conserved Coronaviral coronavirus coronavirus 229E Coronavirus infection Coronavirus replication Coronaviruses Culture early phase epithelia genome replication hallmark highly pathogenic Host host cell cytoplasm implicated Including infections inhibit inhibition inhibitor knowledge membrane membrane vesicle membrane-bound membranes MERS-CoV MERS–CoV Middle East mutant Mutation non-structural protein not affected positive potent raise recruitment reduced replicate Replication representing respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus RNA viruses SARS-CoV screened Substitution synthesis target targeting Transcription Treatment viral life cycle viral replication viral RNA synthesis virus virus entry zoonotic [DOI] 10.1371/journal.ppat.1004166 PMC 바로가기 [Article Type] Research Article
“Even if the test result is negative, they should be able to tell us what is wrong with us” : a qualitative study of patient expectations of rapid diagnostic tests for malaria“검사 결과가 음성이더라도, 그들은 우리에게 무엇이 잘못되었는지 알려줄 수 있어야 한다”: 말라리아에 대한 신속 진단 검사에 대한 환자의 기대에 대한 질적 연구Research Published on 2013-07-222024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Act Diagnosis expectations malaria Patient perceptions Rapid diagnostic tests targeting Test-driven [DOI] 10.1186/1475-2875-12-258 PMC 바로가기 [Article Type] Research